SELENBP1 inhibits progression of colorectal cancer by suppressing epithelial–mesenchymal transition
Selenium-binding protein 1 (SELENBP1) is frequently dysregulated in various malignancies including colorectal cancer (CRC); however, its roles in progression of CRCs and the underlying mechanism remain to be elucidated. In this study, we compared the expression of SELENBP1 between CRCs and colorecta...
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| Format: | Article |
| Language: | English |
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De Gruyter
2022-09-01
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| Series: | Open Medicine |
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| Online Access: | https://doi.org/10.1515/med-2022-0532 |
| _version_ | 1818025281107001344 |
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| author | Zhang Xiaotian Hong Runqi Bei Lanxin Hu Zhiqing Yang Ximin Song Tao Chen Liang Meng He Niu Gengming Ke Chongwei |
| author_facet | Zhang Xiaotian Hong Runqi Bei Lanxin Hu Zhiqing Yang Ximin Song Tao Chen Liang Meng He Niu Gengming Ke Chongwei |
| author_sort | Zhang Xiaotian |
| collection | DOAJ |
| description | Selenium-binding protein 1 (SELENBP1) is frequently dysregulated in various malignancies including colorectal cancer (CRC); however, its roles in progression of CRCs and the underlying mechanism remain to be elucidated. In this study, we compared the expression of SELENBP1 between CRCs and colorectal normal tissues (NTs), as well as between primary and metastatic CRCs; we determined the association between SELENBP1 expression and CRC patient prognoses; we conducted both in vitro and in vivo experiments to explore the functional roles of SELENBP1 in CRC progression; and we characterized the potential underlying mechanisms associated with SELENBP1 activities. We found that the expression of SELENBP1 was significantly and consistently decreased in CRCs than that in adjacent NTs, while significantly and frequently decreased in metastatic than primary CRCs. High expression of SELENBP1 was an independent predictor of favorable prognoses in CRC patients. Overexpression of SELENBP1 suppressed, while silencing of SELENBP1 promoted cell proliferation, migration and invasion, and in vivo tumorigenesis of CRC. Mechanically, SELENBP1 may suppress CRC progression by inhibiting the epithelial–mesenchymal transition. |
| first_indexed | 2024-12-10T04:13:37Z |
| format | Article |
| id | doaj.art-09f4e1bd44784b04a7361a74a7f35379 |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-12-10T04:13:37Z |
| publishDate | 2022-09-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj.art-09f4e1bd44784b04a7361a74a7f353792022-12-22T02:02:39ZengDe GruyterOpen Medicine2391-54632022-09-011711390140410.1515/med-2022-0532SELENBP1 inhibits progression of colorectal cancer by suppressing epithelial–mesenchymal transitionZhang Xiaotian0Hong Runqi1Bei Lanxin2Hu Zhiqing3Yang Ximin4Song Tao5Chen Liang6Meng He7Niu Gengming8Ke Chongwei9Department of General Surgery, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, 200240, P.R. ChinaDepartment of General Surgery, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, 200240, P.R. ChinaDepartment of Animal Science, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, ChinaDepartment of General Surgery, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, 200240, P.R. ChinaDepartment of Radiology, Dongying New District Hospital, Dongying, Shandong Province, 257000, P.R. ChinaDepartment of General Surgery, Shanghai Fifth People’s Hospital, Fudan University, 801 Heqing Road, Minhang District, Shanghai, 200240, P.R. ChinaDepartment of General Surgery, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, 200240, P.R. ChinaDepartment of Animal Science, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, ChinaDepartment of General Surgery, Shanghai Fifth People’s Hospital, Fudan University, 801 Heqing Road, Minhang District, Shanghai, 200240, P.R. ChinaDepartment of General Surgery, Shanghai Fifth People’s Hospital, Fudan University, 801 Heqing Road, Minhang District, Shanghai, 200240, P.R. ChinaSelenium-binding protein 1 (SELENBP1) is frequently dysregulated in various malignancies including colorectal cancer (CRC); however, its roles in progression of CRCs and the underlying mechanism remain to be elucidated. In this study, we compared the expression of SELENBP1 between CRCs and colorectal normal tissues (NTs), as well as between primary and metastatic CRCs; we determined the association between SELENBP1 expression and CRC patient prognoses; we conducted both in vitro and in vivo experiments to explore the functional roles of SELENBP1 in CRC progression; and we characterized the potential underlying mechanisms associated with SELENBP1 activities. We found that the expression of SELENBP1 was significantly and consistently decreased in CRCs than that in adjacent NTs, while significantly and frequently decreased in metastatic than primary CRCs. High expression of SELENBP1 was an independent predictor of favorable prognoses in CRC patients. Overexpression of SELENBP1 suppressed, while silencing of SELENBP1 promoted cell proliferation, migration and invasion, and in vivo tumorigenesis of CRC. Mechanically, SELENBP1 may suppress CRC progression by inhibiting the epithelial–mesenchymal transition.https://doi.org/10.1515/med-2022-0532selenium-binding protein 1colorectal cancerprogressiontumorigenesisepithelial–mesenchymal transition |
| spellingShingle | Zhang Xiaotian Hong Runqi Bei Lanxin Hu Zhiqing Yang Ximin Song Tao Chen Liang Meng He Niu Gengming Ke Chongwei SELENBP1 inhibits progression of colorectal cancer by suppressing epithelial–mesenchymal transition Open Medicine selenium-binding protein 1 colorectal cancer progression tumorigenesis epithelial–mesenchymal transition |
| title | SELENBP1 inhibits progression of colorectal cancer by suppressing epithelial–mesenchymal transition |
| title_full | SELENBP1 inhibits progression of colorectal cancer by suppressing epithelial–mesenchymal transition |
| title_fullStr | SELENBP1 inhibits progression of colorectal cancer by suppressing epithelial–mesenchymal transition |
| title_full_unstemmed | SELENBP1 inhibits progression of colorectal cancer by suppressing epithelial–mesenchymal transition |
| title_short | SELENBP1 inhibits progression of colorectal cancer by suppressing epithelial–mesenchymal transition |
| title_sort | selenbp1 inhibits progression of colorectal cancer by suppressing epithelial mesenchymal transition |
| topic | selenium-binding protein 1 colorectal cancer progression tumorigenesis epithelial–mesenchymal transition |
| url | https://doi.org/10.1515/med-2022-0532 |
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