Structure and Dynamics of a Site-Specific Labeled Fc Fragment with Altered Effector Functions

Structure and Dynamics of a Site-Specific Labeled Fc Fragment with Altered Effector Functions

Antibody-drug conjugates (ADCs) are a class of biotherapeutic drugs designed as targeted therapies for the treatment of cancer. Among the challenges in generating an effective ADC is the choice of an effective conjugation site on the IgG. One common method to prepare site-specific ADCs is to enginee...

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Bibliographic Details
Main Authors: D. Travis Gallagher, Chris McCullough, Robert G. Brinson, Joomi Ahn, John P. Marino, Nazzareno Dimasi
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Pharmaceutics
Subjects:
antibody drug conjugates
antibody fc engineering
x-ray crystallography
hydrogen-deuterium exchange mass spectroscopy
Online Access:https://www.mdpi.com/1999-4923/11/10/546

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