False pharmacoresistance – a true problem

Pharmacoresistant epilepsy poses a great burden to patients, their families, and the whole healthcare system, with numerous social, economic, physical, and psychical consequences. Hence, it is a diagnosis that has to be made only in cases of high certainty, after all potential causes of epilepsy...

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Main Authors: Silvio Bašić, Ivana Marković, Davor Sporiš, Ivana Šušak Sporiš, Filip Đerke, Ivana Mrđen
Format: Article
Language:English
Published: Sestre Milosrdnice University hospital, Institute of Clinical Medical Research 2021-01-01
Series:Acta Clinica Croatica
Subjects:
Online Access:https://hrcak.srce.hr/file/407495
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author Silvio Bašić
Ivana Marković
Davor Sporiš
Ivana Šušak Sporiš
Filip Đerke
Ivana Mrđen
author_facet Silvio Bašić
Ivana Marković
Davor Sporiš
Ivana Šušak Sporiš
Filip Đerke
Ivana Mrđen
author_sort Silvio Bašić
collection DOAJ
description Pharmacoresistant epilepsy poses a great burden to patients, their families, and the whole healthcare system, with numerous social, economic, physical, and psychical consequences. Hence, it is a diagnosis that has to be made only in cases of high certainty, after all potential causes of epilepsy have been evaluated. One of the important causes of pharmacoresistant epilepsy is false pharmacoresistance, an entity that implies a condition in which poor disease control is not a consequence of the biology of the disease itself, antiepileptic drug inefficacy, and/or patient specificity. It is a consequence of human error and strongly depends on the experience of the treating physician, as well as on the attitude of the patient. Despite its ‘falseness’, this entity is accompanied by real consequences for the patient and his family, and at the same time, it delays appropriate treatment of the actual disease from which the patient is suffering. In order to introduce appropriate treatment and avoid unnecessary and harmful diagnostic procedures, false pharmacoresistance is a condition that has to be ruled out in any patient with difficult-to-treat seizures.
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spelling doaj.art-09fc58560d1e48008dd1be394e89c6842024-04-15T17:54:12ZengSestre Milosrdnice University hospital, Institute of Clinical Medical ResearchActa Clinica Croatica0353-94661333-94512021-01-0160.Supplement 391510.20471/acc.2021.60.s3.01False pharmacoresistance – a true problemSilvio Bašić0Ivana Marković1Davor Sporiš2Ivana Šušak Sporiš3Filip Đerke4Ivana Mrđen5Department of Neurology, Dubrava University Hospital, Zagreb, Croatia; Department of Psychiatry and Neurology, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University, Osijek, CroatiaDepartment of Neurology, Dubrava University Hospital, Zagreb, Croatia; Department of Psychiatry and Neurology, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University, Osijek, CroatiaDepartment of Neurology, Dubrava University Hospital, Zagreb, Croatia; Department of Psychiatry and Neurology, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University, Osijek, CroatiaDepartment of Neurology, Dubrava University Hospital, Zagreb, Croatia; Department of Psychiatry and Neurology, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University, Osijek, CroatiaDepartment of Neurology, Dubrava University Hospital, Zagreb, Croatia; Department of Psychiatry and Neurology, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University, Osijek, CroatiaDepartment of Neurology, Zadar General Hospital, Zadar, CroatiaPharmacoresistant epilepsy poses a great burden to patients, their families, and the whole healthcare system, with numerous social, economic, physical, and psychical consequences. Hence, it is a diagnosis that has to be made only in cases of high certainty, after all potential causes of epilepsy have been evaluated. One of the important causes of pharmacoresistant epilepsy is false pharmacoresistance, an entity that implies a condition in which poor disease control is not a consequence of the biology of the disease itself, antiepileptic drug inefficacy, and/or patient specificity. It is a consequence of human error and strongly depends on the experience of the treating physician, as well as on the attitude of the patient. Despite its ‘falseness’, this entity is accompanied by real consequences for the patient and his family, and at the same time, it delays appropriate treatment of the actual disease from which the patient is suffering. In order to introduce appropriate treatment and avoid unnecessary and harmful diagnostic procedures, false pharmacoresistance is a condition that has to be ruled out in any patient with difficult-to-treat seizures.https://hrcak.srce.hr/file/407495EpilepsyFalse pharmacoresistanceAntiepileptic drugsPharmacoresistant epilepsy
spellingShingle Silvio Bašić
Ivana Marković
Davor Sporiš
Ivana Šušak Sporiš
Filip Đerke
Ivana Mrđen
False pharmacoresistance – a true problem
Acta Clinica Croatica
Epilepsy
False pharmacoresistance
Antiepileptic drugs
Pharmacoresistant epilepsy
title False pharmacoresistance – a true problem
title_full False pharmacoresistance – a true problem
title_fullStr False pharmacoresistance – a true problem
title_full_unstemmed False pharmacoresistance – a true problem
title_short False pharmacoresistance – a true problem
title_sort false pharmacoresistance a true problem
topic Epilepsy
False pharmacoresistance
Antiepileptic drugs
Pharmacoresistant epilepsy
url https://hrcak.srce.hr/file/407495
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AT ivanamarkovic falsepharmacoresistanceatrueproblem
AT davorsporis falsepharmacoresistanceatrueproblem
AT ivanasusaksporis falsepharmacoresistanceatrueproblem
AT filipđerke falsepharmacoresistanceatrueproblem
AT ivanamrđen falsepharmacoresistanceatrueproblem