Clinical Factors Associated with COVID-19 Severity in Mexican Patients: Cross-Sectional Analysis from a Multicentric Hospital Study
(1) Background: Latin America has been harshly hit by SARS-CoV-2, but reporting from this region is still incomplete. This study aimed at identifying and comparing clinical characteristics of patients with COVID-19 at different stages of disease severity. (2) Methods: Cross-sectional multicentric st...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Healthcare |
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| Online Access: | https://www.mdpi.com/2227-9032/9/7/895 |
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| author | Joel Monárrez-Espino Carolina Ivette Zubía-Nevárez Lorena Reyes-Silva Juan Pablo Castillo-Palencia Julio Enrique Castañeda-Delgado Ana Sofía Herrera van-Oostdam Yamilé López-Hernández |
| author_facet | Joel Monárrez-Espino Carolina Ivette Zubía-Nevárez Lorena Reyes-Silva Juan Pablo Castillo-Palencia Julio Enrique Castañeda-Delgado Ana Sofía Herrera van-Oostdam Yamilé López-Hernández |
| author_sort | Joel Monárrez-Espino |
| collection | DOAJ |
| description | (1) Background: Latin America has been harshly hit by SARS-CoV-2, but reporting from this region is still incomplete. This study aimed at identifying and comparing clinical characteristics of patients with COVID-19 at different stages of disease severity. (2) Methods: Cross-sectional multicentric study. Individuals with nasopharyngeal PCR were categorized into four groups: (1) negative, (2) positive, not hospitalized, (3) positive, hospitalized with/without supplementary oxygen, and (4) positive, intubated. Clinical and laboratory data were compared, using group 1 as the reference. Multivariate multinomial logistic regression was used to compare adjusted odds ratios. (3) Results: Nine variables remained in the model, explaining 76% of the variability. Men had increased odds, from 1.90 (95%CI 0.87–4.15) in the comparison of 2 vs. 1, to 3.66 (1.12–11.9) in 4 vs. 1. Diabetes and obesity were strong predictors. For diabetes, the odds for groups 2, 3, and 4 were 1.56 (0.29–8.16), 12.8 (2.50–65.8), and 16.1 (2.87–90.2); for obesity, these were 0.79 (0.31–2.05), 3.38 (1.04–10.9), and 4.10 (1.16–14.4), respectively. Fever, myalgia/arthralgia, cough, dyspnea, and neutrophilia were associated with the more severe COVID-19 group. Anosmia/dysgeusia were more likely to occur in group 2 (25.5; 2.51–259). (4) Conclusion: The results point to relevant differences in clinical and laboratory features of COVID-19 by level of severity that can be used in medical practice. |
| first_indexed | 2024-03-10T09:37:52Z |
| format | Article |
| id | doaj.art-09fcce83cfd149ea89429796d9d787a2 |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-10T09:37:52Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-09fcce83cfd149ea89429796d9d787a22023-11-22T03:53:00ZengMDPI AGHealthcare2227-90322021-07-019789510.3390/healthcare9070895Clinical Factors Associated with COVID-19 Severity in Mexican Patients: Cross-Sectional Analysis from a Multicentric Hospital StudyJoel Monárrez-Espino0Carolina Ivette Zubía-Nevárez1Lorena Reyes-Silva2Juan Pablo Castillo-Palencia3Julio Enrique Castañeda-Delgado4Ana Sofía Herrera van-Oostdam5Yamilé López-Hernández6Department of Health Research, Christus Muguerza del Parque Hospital, Chihuahua 31000, MexicoVice Presidency of Health Sciences, Medical Specialties Program, University of Monterrey, San Pedro Garza García 66238, MexicoDepartment of Health Research, Christus Muguerza del Parque Hospital, Chihuahua 31000, MexicoGeneral Hospital of Soledad de Graciano Sánchez, San Luis Potosí Health Services, Soledad de Graciano Sánchez 78435, MexicoBiomedical Research Unit, Mexican Institute of Social Security, Zacatecas 98000, MexicoBiochemistry Department, San Luis Potosí Autonomous University, San Luis Potosí 78290, MexicoMetabolomics and Proteomics Laboratory, Mexican Council of Science and Technology, Zacatecas Autonomous University, Zacatecas 98000, Mexico(1) Background: Latin America has been harshly hit by SARS-CoV-2, but reporting from this region is still incomplete. This study aimed at identifying and comparing clinical characteristics of patients with COVID-19 at different stages of disease severity. (2) Methods: Cross-sectional multicentric study. Individuals with nasopharyngeal PCR were categorized into four groups: (1) negative, (2) positive, not hospitalized, (3) positive, hospitalized with/without supplementary oxygen, and (4) positive, intubated. Clinical and laboratory data were compared, using group 1 as the reference. Multivariate multinomial logistic regression was used to compare adjusted odds ratios. (3) Results: Nine variables remained in the model, explaining 76% of the variability. Men had increased odds, from 1.90 (95%CI 0.87–4.15) in the comparison of 2 vs. 1, to 3.66 (1.12–11.9) in 4 vs. 1. Diabetes and obesity were strong predictors. For diabetes, the odds for groups 2, 3, and 4 were 1.56 (0.29–8.16), 12.8 (2.50–65.8), and 16.1 (2.87–90.2); for obesity, these were 0.79 (0.31–2.05), 3.38 (1.04–10.9), and 4.10 (1.16–14.4), respectively. Fever, myalgia/arthralgia, cough, dyspnea, and neutrophilia were associated with the more severe COVID-19 group. Anosmia/dysgeusia were more likely to occur in group 2 (25.5; 2.51–259). (4) Conclusion: The results point to relevant differences in clinical and laboratory features of COVID-19 by level of severity that can be used in medical practice.https://www.mdpi.com/2227-9032/9/7/895COVID-19disease severityMexicomultivariate analysissigns and symptoms |
| spellingShingle | Joel Monárrez-Espino Carolina Ivette Zubía-Nevárez Lorena Reyes-Silva Juan Pablo Castillo-Palencia Julio Enrique Castañeda-Delgado Ana Sofía Herrera van-Oostdam Yamilé López-Hernández Clinical Factors Associated with COVID-19 Severity in Mexican Patients: Cross-Sectional Analysis from a Multicentric Hospital Study Healthcare COVID-19 disease severity Mexico multivariate analysis signs and symptoms |
| title | Clinical Factors Associated with COVID-19 Severity in Mexican Patients: Cross-Sectional Analysis from a Multicentric Hospital Study |
| title_full | Clinical Factors Associated with COVID-19 Severity in Mexican Patients: Cross-Sectional Analysis from a Multicentric Hospital Study |
| title_fullStr | Clinical Factors Associated with COVID-19 Severity in Mexican Patients: Cross-Sectional Analysis from a Multicentric Hospital Study |
| title_full_unstemmed | Clinical Factors Associated with COVID-19 Severity in Mexican Patients: Cross-Sectional Analysis from a Multicentric Hospital Study |
| title_short | Clinical Factors Associated with COVID-19 Severity in Mexican Patients: Cross-Sectional Analysis from a Multicentric Hospital Study |
| title_sort | clinical factors associated with covid 19 severity in mexican patients cross sectional analysis from a multicentric hospital study |
| topic | COVID-19 disease severity Mexico multivariate analysis signs and symptoms |
| url | https://www.mdpi.com/2227-9032/9/7/895 |
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