Exploration of the interaction between remote ischemic preconditioning and anesthetic-induced preconditioning using sevoflurane in isolated perfused rabbit heart
Objectives: Remote ischemic preconditioning (rIPC) is a novel technique in which brief episodes of ischemia and reperfusion in one organ confer protection against prolonged ischemia in a distant organ. In contrast, anesthetic-induced preconditioning (APC) utilizes volatile anesthetics to protect mul...
| Główni autorzy: | , , , |
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| Format: | Artykuł |
| Język: | English |
| Wydane: |
Ewha Womans University College of Medicine
2024-10-01
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| Seria: | The Ewha Medical Journal |
| Hasła przedmiotowe: | |
| Dostęp online: | http://www.e-emj.org/archive/view_article?pid=emj-47-4-61 |
| _version_ | 1826931631874637824 |
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| author | Seung-Hee Yoo Sooyoung Cho Yoonsun Won Jong Wha Lee |
| author_facet | Seung-Hee Yoo Sooyoung Cho Yoonsun Won Jong Wha Lee |
| author_sort | Seung-Hee Yoo |
| collection | DOAJ |
| description | Objectives: Remote ischemic preconditioning (rIPC) is a novel technique in which brief episodes of ischemia and reperfusion in one organ confer protection against prolonged ischemia in a distant organ. In contrast, anesthetic-induced preconditioning (APC) utilizes volatile anesthetics to protect multiple organs from ischemia-reperfusion injury. Both methods are easily integrated into various clinical scenarios for cardioprotection. However, it remains unclear whether simultaneous application of these techniques could result in complementary, additive, synergistic, or adverse effects.
Methods: An adult rabbit heart Langendorff model of global ischemia/reperfusion injury was used to compare the cardioprotective effect of rIPC and APC alone and in combination relative to untreated (control) hearts. The rIPC group underwent four cycles of 5-minute ischemia on the hind limb, each followed by 5 minutes of reperfusion. The APC group received 2.5 vol% sevoflurane for 20 minutes via a face mask, followed by a 20-minute washout period.
Results: Both in vivo rIPC, induced by four 5-minute cycles of ischemia/reperfusion on the hind limb, and APC, administered as 2.5 vol% sevoflurane via a mask, significantly reduced the size of myocardial infarction following 30 minutes of global ischemia by >50% compared to the untreated control group (rIPC, 12.1±1.7%; APC, 13.5±2.1%; P<0.01 compared to control, 31.3±3.0%). However, no additional protective effect was observed when rIPC and APC were combined (rIPC+APC, 14.4±3.3%).
Conclusion: Although combining rIPC and APC did not provide additional protection, there was no inhibitory effect of one intervention on the other. |
| first_indexed | 2025-02-17T16:50:05Z |
| format | Article |
| id | doaj.art-09fe0d57ec4a4e08afbe966c9d2c80d7 |
| institution | Directory Open Access Journal |
| issn | 2234-2591 |
| language | English |
| last_indexed | 2025-02-17T16:50:05Z |
| publishDate | 2024-10-01 |
| publisher | Ewha Womans University College of Medicine |
| record_format | Article |
| series | The Ewha Medical Journal |
| spelling | doaj.art-09fe0d57ec4a4e08afbe966c9d2c80d72024-12-16T08:43:16ZengEwha Womans University College of MedicineThe Ewha Medical Journal2234-25912024-10-0147410.12771/emj.2024.e68emj-47-4-61Exploration of the interaction between remote ischemic preconditioning and anesthetic-induced preconditioning using sevoflurane in isolated perfused rabbit heartSeung-Hee YooSooyoung ChoYoonsun WonJong Wha LeeObjectives: Remote ischemic preconditioning (rIPC) is a novel technique in which brief episodes of ischemia and reperfusion in one organ confer protection against prolonged ischemia in a distant organ. In contrast, anesthetic-induced preconditioning (APC) utilizes volatile anesthetics to protect multiple organs from ischemia-reperfusion injury. Both methods are easily integrated into various clinical scenarios for cardioprotection. However, it remains unclear whether simultaneous application of these techniques could result in complementary, additive, synergistic, or adverse effects. Methods: An adult rabbit heart Langendorff model of global ischemia/reperfusion injury was used to compare the cardioprotective effect of rIPC and APC alone and in combination relative to untreated (control) hearts. The rIPC group underwent four cycles of 5-minute ischemia on the hind limb, each followed by 5 minutes of reperfusion. The APC group received 2.5 vol% sevoflurane for 20 minutes via a face mask, followed by a 20-minute washout period. Results: Both in vivo rIPC, induced by four 5-minute cycles of ischemia/reperfusion on the hind limb, and APC, administered as 2.5 vol% sevoflurane via a mask, significantly reduced the size of myocardial infarction following 30 minutes of global ischemia by >50% compared to the untreated control group (rIPC, 12.1±1.7%; APC, 13.5±2.1%; P<0.01 compared to control, 31.3±3.0%). However, no additional protective effect was observed when rIPC and APC were combined (rIPC+APC, 14.4±3.3%). Conclusion: Although combining rIPC and APC did not provide additional protection, there was no inhibitory effect of one intervention on the other.http://www.e-emj.org/archive/view_article?pid=emj-47-4-61inhalation anesthesiamyocardial ischemic preconditioningmyocardial reperfusion injuryrabbitssevoflurane |
| spellingShingle | Seung-Hee Yoo Sooyoung Cho Yoonsun Won Jong Wha Lee Exploration of the interaction between remote ischemic preconditioning and anesthetic-induced preconditioning using sevoflurane in isolated perfused rabbit heart The Ewha Medical Journal inhalation anesthesia myocardial ischemic preconditioning myocardial reperfusion injury rabbits sevoflurane |
| title | Exploration of the interaction between remote ischemic preconditioning and anesthetic-induced preconditioning using sevoflurane in isolated perfused rabbit heart |
| title_full | Exploration of the interaction between remote ischemic preconditioning and anesthetic-induced preconditioning using sevoflurane in isolated perfused rabbit heart |
| title_fullStr | Exploration of the interaction between remote ischemic preconditioning and anesthetic-induced preconditioning using sevoflurane in isolated perfused rabbit heart |
| title_full_unstemmed | Exploration of the interaction between remote ischemic preconditioning and anesthetic-induced preconditioning using sevoflurane in isolated perfused rabbit heart |
| title_short | Exploration of the interaction between remote ischemic preconditioning and anesthetic-induced preconditioning using sevoflurane in isolated perfused rabbit heart |
| title_sort | exploration of the interaction between remote ischemic preconditioning and anesthetic induced preconditioning using sevoflurane in isolated perfused rabbit heart |
| topic | inhalation anesthesia myocardial ischemic preconditioning myocardial reperfusion injury rabbits sevoflurane |
| url | http://www.e-emj.org/archive/view_article?pid=emj-47-4-61 |
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