Longitudinal trajectory of amplitude of low-frequency fluctuation changes in breast cancer patients during neoadjuvant chemotherapy–A preliminary prospective study
There is growing evidence that the amplitude of low-frequency fluctuation (ALFF) changes in breast cancer patients after chemotherapy. However, longitudinal changes in ALFF during chemotherapy are unclear. To assess the trajectory of ALFF changes during chemotherapy, 36 breast cancer patients underw...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-01-01
|
| Series: | Brain Research Bulletin |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923023002708 |
| _version_ | 1797385261922910208 |
|---|---|
| author | Yixin Hu Hong Yu Yong Lai Jiang Liu Yong Tan Weiwei Lei Jing Zhang Xiaoyu Zhou Ying Cao Yu Tang Daihong Liu Jiuquan Zhang |
| author_facet | Yixin Hu Hong Yu Yong Lai Jiang Liu Yong Tan Weiwei Lei Jing Zhang Xiaoyu Zhou Ying Cao Yu Tang Daihong Liu Jiuquan Zhang |
| author_sort | Yixin Hu |
| collection | DOAJ |
| description | There is growing evidence that the amplitude of low-frequency fluctuation (ALFF) changes in breast cancer patients after chemotherapy. However, longitudinal changes in ALFF during chemotherapy are unclear. To assess the trajectory of ALFF changes during chemotherapy, 36 breast cancer patients underwent both resting-state functional magnetic resonance imaging and neuropsychological testing at three time points, including before neoadjuvant chemotherapy (NAC) (time point 0, TP0), after one cycle of NAC (before the second cycle of NAC, TP1), and upon completion of NAC (pre-operation, TP2). Healthy controls (HC) received the same assessments at matching time points. We compared the longitudinal changes of ALFF in the NAC and two HC groups. In the NAC group, compared with TP0, ALFF values in the right orbital part of the inferior frontal gyrus, left medial orbital part of the superior frontal gyrus, right insula, left medial part of the superior frontal gyrus, and right middle frontal gyrus declined significantly at TP1 and TP2. Compared with TP1, there were no significant changes in ALFF values at TP2. In the two HC groups, there were no significant changes in ALFF at corresponding intervals. We concluded that for breast cancer patients receiving NAC, ALFF values declined significantly in some brain regions after one cycle of NAC and then remained stable until the completion of NAC, and most of the brain regions with ALFF changes were located in the frontal lobe. |
| first_indexed | 2024-03-08T21:51:42Z |
| format | Article |
| id | doaj.art-09fe98af39c44cfd81eaaeef289ed970 |
| institution | Directory Open Access Journal |
| issn | 1873-2747 |
| language | English |
| last_indexed | 2024-03-08T21:51:42Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj.art-09fe98af39c44cfd81eaaeef289ed9702023-12-20T07:32:59ZengElsevierBrain Research Bulletin1873-27472024-01-01206110845Longitudinal trajectory of amplitude of low-frequency fluctuation changes in breast cancer patients during neoadjuvant chemotherapy–A preliminary prospective studyYixin Hu0Hong Yu1Yong Lai2Jiang Liu3Yong Tan4Weiwei Lei5Jing Zhang6Xiaoyu Zhou7Ying Cao8Yu Tang9Daihong Liu10Jiuquan Zhang11Department of Radiology, Chongqing University Cancer Hospital, School of Medicine, Chongqing University, Chongqing, ChinaDepartment of Radiology, Chongqing University Cancer Hospital, School of Medicine, Chongqing University, Chongqing, ChinaDepartment of Radiology, Chongqing University Cancer Hospital, School of Medicine, Chongqing University, Chongqing, ChinaDepartment of Radiology, Chongqing University Cancer Hospital, School of Medicine, Chongqing University, Chongqing, ChinaDepartment of Radiology, Chongqing University Cancer Hospital, School of Medicine, Chongqing University, Chongqing, ChinaDepartment of Intensive Care, Chongqing University Cancer Hospital, School of Medicine, Chongqing University, Chongqing, ChinaDepartment of Radiology, Chongqing University Cancer Hospital, School of Medicine, Chongqing University, Chongqing, ChinaDepartment of Radiology, Chongqing University Cancer Hospital, School of Medicine, Chongqing University, Chongqing, ChinaDepartment of Radiology, Chongqing University Cancer Hospital, School of Medicine, Chongqing University, Chongqing, ChinaDepartment of Radiology, Chongqing University Cancer Hospital, School of Medicine, Chongqing University, Chongqing, ChinaDepartment of Radiology, Chongqing University Cancer Hospital, School of Medicine, Chongqing University, Chongqing, China; Corresponding authors.Department of Radiology, Chongqing University Cancer Hospital, School of Medicine, Chongqing University, Chongqing, China; Corresponding authors.There is growing evidence that the amplitude of low-frequency fluctuation (ALFF) changes in breast cancer patients after chemotherapy. However, longitudinal changes in ALFF during chemotherapy are unclear. To assess the trajectory of ALFF changes during chemotherapy, 36 breast cancer patients underwent both resting-state functional magnetic resonance imaging and neuropsychological testing at three time points, including before neoadjuvant chemotherapy (NAC) (time point 0, TP0), after one cycle of NAC (before the second cycle of NAC, TP1), and upon completion of NAC (pre-operation, TP2). Healthy controls (HC) received the same assessments at matching time points. We compared the longitudinal changes of ALFF in the NAC and two HC groups. In the NAC group, compared with TP0, ALFF values in the right orbital part of the inferior frontal gyrus, left medial orbital part of the superior frontal gyrus, right insula, left medial part of the superior frontal gyrus, and right middle frontal gyrus declined significantly at TP1 and TP2. Compared with TP1, there were no significant changes in ALFF values at TP2. In the two HC groups, there were no significant changes in ALFF at corresponding intervals. We concluded that for breast cancer patients receiving NAC, ALFF values declined significantly in some brain regions after one cycle of NAC and then remained stable until the completion of NAC, and most of the brain regions with ALFF changes were located in the frontal lobe.http://www.sciencedirect.com/science/article/pii/S0361923023002708Neoadjuvant chemotherapyBreast cancerAmplitude of low frequency fluctuationMagnetic resonance imaging |
| spellingShingle | Yixin Hu Hong Yu Yong Lai Jiang Liu Yong Tan Weiwei Lei Jing Zhang Xiaoyu Zhou Ying Cao Yu Tang Daihong Liu Jiuquan Zhang Longitudinal trajectory of amplitude of low-frequency fluctuation changes in breast cancer patients during neoadjuvant chemotherapy–A preliminary prospective study Brain Research Bulletin Neoadjuvant chemotherapy Breast cancer Amplitude of low frequency fluctuation Magnetic resonance imaging |
| title | Longitudinal trajectory of amplitude of low-frequency fluctuation changes in breast cancer patients during neoadjuvant chemotherapy–A preliminary prospective study |
| title_full | Longitudinal trajectory of amplitude of low-frequency fluctuation changes in breast cancer patients during neoadjuvant chemotherapy–A preliminary prospective study |
| title_fullStr | Longitudinal trajectory of amplitude of low-frequency fluctuation changes in breast cancer patients during neoadjuvant chemotherapy–A preliminary prospective study |
| title_full_unstemmed | Longitudinal trajectory of amplitude of low-frequency fluctuation changes in breast cancer patients during neoadjuvant chemotherapy–A preliminary prospective study |
| title_short | Longitudinal trajectory of amplitude of low-frequency fluctuation changes in breast cancer patients during neoadjuvant chemotherapy–A preliminary prospective study |
| title_sort | longitudinal trajectory of amplitude of low frequency fluctuation changes in breast cancer patients during neoadjuvant chemotherapy a preliminary prospective study |
| topic | Neoadjuvant chemotherapy Breast cancer Amplitude of low frequency fluctuation Magnetic resonance imaging |
| url | http://www.sciencedirect.com/science/article/pii/S0361923023002708 |
| work_keys_str_mv | AT yixinhu longitudinaltrajectoryofamplitudeoflowfrequencyfluctuationchangesinbreastcancerpatientsduringneoadjuvantchemotherapyapreliminaryprospectivestudy AT hongyu longitudinaltrajectoryofamplitudeoflowfrequencyfluctuationchangesinbreastcancerpatientsduringneoadjuvantchemotherapyapreliminaryprospectivestudy AT yonglai longitudinaltrajectoryofamplitudeoflowfrequencyfluctuationchangesinbreastcancerpatientsduringneoadjuvantchemotherapyapreliminaryprospectivestudy AT jiangliu longitudinaltrajectoryofamplitudeoflowfrequencyfluctuationchangesinbreastcancerpatientsduringneoadjuvantchemotherapyapreliminaryprospectivestudy AT yongtan longitudinaltrajectoryofamplitudeoflowfrequencyfluctuationchangesinbreastcancerpatientsduringneoadjuvantchemotherapyapreliminaryprospectivestudy AT weiweilei longitudinaltrajectoryofamplitudeoflowfrequencyfluctuationchangesinbreastcancerpatientsduringneoadjuvantchemotherapyapreliminaryprospectivestudy AT jingzhang longitudinaltrajectoryofamplitudeoflowfrequencyfluctuationchangesinbreastcancerpatientsduringneoadjuvantchemotherapyapreliminaryprospectivestudy AT xiaoyuzhou longitudinaltrajectoryofamplitudeoflowfrequencyfluctuationchangesinbreastcancerpatientsduringneoadjuvantchemotherapyapreliminaryprospectivestudy AT yingcao longitudinaltrajectoryofamplitudeoflowfrequencyfluctuationchangesinbreastcancerpatientsduringneoadjuvantchemotherapyapreliminaryprospectivestudy AT yutang longitudinaltrajectoryofamplitudeoflowfrequencyfluctuationchangesinbreastcancerpatientsduringneoadjuvantchemotherapyapreliminaryprospectivestudy AT daihongliu longitudinaltrajectoryofamplitudeoflowfrequencyfluctuationchangesinbreastcancerpatientsduringneoadjuvantchemotherapyapreliminaryprospectivestudy AT jiuquanzhang longitudinaltrajectoryofamplitudeoflowfrequencyfluctuationchangesinbreastcancerpatientsduringneoadjuvantchemotherapyapreliminaryprospectivestudy |