Evaluation of Bioactive Effects of Five Plant Extracts with Different Phenolic Compositions against Different Therapeutic Targets
Plant extracts rich in phenolic compounds have been reported to exert different bioactive properties. Despite the fact that there are plant extracts with completely different phenolic compositions, many of them have been reported to have similar beneficial properties. Thus, the structure–bioactivity...
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| Format: | Article |
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MDPI AG
2024-02-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/13/2/217 |
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| author | María del Carmen Villegas-Aguilar Noelia Sánchez-Marzo Álvaro Fernández-Ochoa Carmen Del Río Joan Montaner Vicente Micol María Herranz-López Enrique Barrajón-Catalán David Arráez-Román María de la Luz Cádiz-Gurrea Antonio Segura-Carretero |
| author_facet | María del Carmen Villegas-Aguilar Noelia Sánchez-Marzo Álvaro Fernández-Ochoa Carmen Del Río Joan Montaner Vicente Micol María Herranz-López Enrique Barrajón-Catalán David Arráez-Román María de la Luz Cádiz-Gurrea Antonio Segura-Carretero |
| author_sort | María del Carmen Villegas-Aguilar |
| collection | DOAJ |
| description | Plant extracts rich in phenolic compounds have been reported to exert different bioactive properties. Despite the fact that there are plant extracts with completely different phenolic compositions, many of them have been reported to have similar beneficial properties. Thus, the structure–bioactivity relationship mechanisms are not yet known in detail for specific classes of phenolic compounds. In this context, this work aims to demonstrate the relationship of extracts with different phenolic compositions versus different bioactive targets. For this purpose, five plant matrices (<i>Theobroma cacao</i>, <i>Hibiscus sabdariffa</i>, <i>Silybum marianum</i>, <i>Lippia citriodora</i>, and <i>Olea europaea</i>) were selected to cover different phenolic compositions, which were confirmed by the phytochemical characterization analysis performed by HPLC-ESI-qTOF-MS. The bioactive targets evaluated were the antioxidant potential, the free radical scavenging potential, and the inhibitory capacity of different enzymes involved in inflammatory processes, skin aging, and neuroprotection. The results showed that despite the different phenolic compositions of the five matrices, they all showed a bioactive positive effect in most of the evaluated assays. In particular, matrices with very different phenolic contents, such as <i>T. cacao</i> and <i>S. marianum,</i> exerted a similar inhibitory power in enzymes involved in inflammatory processes and skin aging. It should also be noted that <i>H. sabdariffa</i> and <i>T. cacao</i> extracts had a low phenolic content but nevertheless stood out for their bioactive antioxidant and anti-radical capacity. Hence, this research highlights the shared bioactive properties among phenolic compounds found in diverse matrices. The abundance of different phenolic compound families highlights their elevated bioactivity against diverse biological targets. |
| first_indexed | 2024-03-07T22:44:11Z |
| format | Article |
| id | doaj.art-09ff198b91cb438694e699adb1559009 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-07T22:44:11Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-09ff198b91cb438694e699adb15590092024-02-23T15:05:31ZengMDPI AGAntioxidants2076-39212024-02-0113221710.3390/antiox13020217Evaluation of Bioactive Effects of Five Plant Extracts with Different Phenolic Compositions against Different Therapeutic TargetsMaría del Carmen Villegas-Aguilar0Noelia Sánchez-Marzo1Álvaro Fernández-Ochoa2Carmen Del Río3Joan Montaner4Vicente Micol5María Herranz-López6Enrique Barrajón-Catalán7David Arráez-Román8María de la Luz Cádiz-Gurrea9Antonio Segura-Carretero10Department of Analytical Chemistry, University of Granada, 18071 Granada, SpainInstitute of Research, Development and Innovation in Biotechnology of Elche (IDiBE) Miguel Hernández University (UMH), 03202 Elche, SpainDepartment of Analytical Chemistry, University of Granada, 18071 Granada, SpainInstitute of Biomedicine of Seville (IBiS), Hospital Universitario Virgen del Rocío, CSIC, Universidad de Sevilla, 41013 Seville, SpainInstitute of Biomedicine of Seville (IBiS), Hospital Universitario Virgen del Rocío, CSIC, Universidad de Sevilla, 41013 Seville, SpainInstitute of Research, Development and Innovation in Biotechnology of Elche (IDiBE) Miguel Hernández University (UMH), 03202 Elche, SpainInstitute of Research, Development and Innovation in Biotechnology of Elche (IDiBE) Miguel Hernández University (UMH), 03202 Elche, SpainInstitute of Research, Development and Innovation in Biotechnology of Elche (IDiBE) Miguel Hernández University (UMH), 03202 Elche, SpainDepartment of Analytical Chemistry, University of Granada, 18071 Granada, SpainDepartment of Analytical Chemistry, University of Granada, 18071 Granada, SpainDepartment of Analytical Chemistry, University of Granada, 18071 Granada, SpainPlant extracts rich in phenolic compounds have been reported to exert different bioactive properties. Despite the fact that there are plant extracts with completely different phenolic compositions, many of them have been reported to have similar beneficial properties. Thus, the structure–bioactivity relationship mechanisms are not yet known in detail for specific classes of phenolic compounds. In this context, this work aims to demonstrate the relationship of extracts with different phenolic compositions versus different bioactive targets. For this purpose, five plant matrices (<i>Theobroma cacao</i>, <i>Hibiscus sabdariffa</i>, <i>Silybum marianum</i>, <i>Lippia citriodora</i>, and <i>Olea europaea</i>) were selected to cover different phenolic compositions, which were confirmed by the phytochemical characterization analysis performed by HPLC-ESI-qTOF-MS. The bioactive targets evaluated were the antioxidant potential, the free radical scavenging potential, and the inhibitory capacity of different enzymes involved in inflammatory processes, skin aging, and neuroprotection. The results showed that despite the different phenolic compositions of the five matrices, they all showed a bioactive positive effect in most of the evaluated assays. In particular, matrices with very different phenolic contents, such as <i>T. cacao</i> and <i>S. marianum,</i> exerted a similar inhibitory power in enzymes involved in inflammatory processes and skin aging. It should also be noted that <i>H. sabdariffa</i> and <i>T. cacao</i> extracts had a low phenolic content but nevertheless stood out for their bioactive antioxidant and anti-radical capacity. Hence, this research highlights the shared bioactive properties among phenolic compounds found in diverse matrices. The abundance of different phenolic compound families highlights their elevated bioactivity against diverse biological targets.https://www.mdpi.com/2076-3921/13/2/217phenolic compoundHPLC-MSfree radical scavenging capacityenzyme inhibitionantioxidantneuroprotection |
| spellingShingle | María del Carmen Villegas-Aguilar Noelia Sánchez-Marzo Álvaro Fernández-Ochoa Carmen Del Río Joan Montaner Vicente Micol María Herranz-López Enrique Barrajón-Catalán David Arráez-Román María de la Luz Cádiz-Gurrea Antonio Segura-Carretero Evaluation of Bioactive Effects of Five Plant Extracts with Different Phenolic Compositions against Different Therapeutic Targets Antioxidants phenolic compound HPLC-MS free radical scavenging capacity enzyme inhibition antioxidant neuroprotection |
| title | Evaluation of Bioactive Effects of Five Plant Extracts with Different Phenolic Compositions against Different Therapeutic Targets |
| title_full | Evaluation of Bioactive Effects of Five Plant Extracts with Different Phenolic Compositions against Different Therapeutic Targets |
| title_fullStr | Evaluation of Bioactive Effects of Five Plant Extracts with Different Phenolic Compositions against Different Therapeutic Targets |
| title_full_unstemmed | Evaluation of Bioactive Effects of Five Plant Extracts with Different Phenolic Compositions against Different Therapeutic Targets |
| title_short | Evaluation of Bioactive Effects of Five Plant Extracts with Different Phenolic Compositions against Different Therapeutic Targets |
| title_sort | evaluation of bioactive effects of five plant extracts with different phenolic compositions against different therapeutic targets |
| topic | phenolic compound HPLC-MS free radical scavenging capacity enzyme inhibition antioxidant neuroprotection |
| url | https://www.mdpi.com/2076-3921/13/2/217 |
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