Identification of a peptide ligand for human ALDH3A1 through peptide phage display: Prediction and characterization of protein interaction sites and inhibition of ALDH3A1 enzymatic activity

Identification of a peptide ligand for human ALDH3A1 through peptide phage display: Prediction and characterization of protein interaction sites and inhibition of ALDH3A1 enzymatic activity

Aldehyde dehydrogenase 3A1 (ALDH3A1) by oxidizing medium chain aldehydes to their corresponding carboxylic acids, is involved in the detoxification of toxic byproducts and is considered to play an important role in antioxidant cellular defense. ALDH3A1 has been implicated in various other functions...

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Bibliographic Details
Main Authors: Georgia-Persephoni Voulgaridou, Vasileios Theologidis, Vasileios Xanthis, Eleni Papagiannaki, Ilias Tsochantaridis, Vasiliki E. Fadouloglou, Aglaia Pappa
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Molecular Biosciences
Subjects:
aldehyde dehydrogenase
ALDH3A1
phage display
protein-protein interactions
enzyme inhibitor
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1161111/full

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