BECLIN-1-Mediated Autophagy Suppresses Silica Nanoparticle-Induced Testicular Toxicity via the Inhibition of Caspase 8-Mediated Cell Apoptosis in Leydig Cells

BECLIN-1-Mediated Autophagy Suppresses Silica Nanoparticle-Induced Testicular Toxicity via the Inhibition of Caspase 8-Mediated Cell Apoptosis in Leydig Cells

Accumulation of silica nanoparticles (SNPs) in the testes leads to male reproductive toxicity. However, little is known about the effect and mechanistic insights of SNP-induced autophagy on apoptosis in Leydig cells. In this study, we aimed to verify the role of SNP-induced autophagy in apoptosis an...

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Bibliographic Details
Main Authors: Qianru Zhang, Jason William Grunberger, Nitish Khurana, Xin Zhou, Xianyu Xu, Hamidreza Ghandehari, Fenglei Chen
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cells
Subjects:
silica nanoparticles
BECLIN-1
autophagy
apoptosis
Leydig cells
testicular toxicity
Online Access:https://www.mdpi.com/2073-4409/11/12/1863

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