Macronutrient Quality and All-Cause Mortality in the SUN Cohort
No previous study has assessed the relationship between overall macronutrient quality and all-cause mortality. We aimed to prospectively examine the association between a multidimensional macronutrient quality index (MQI) and all-cause mortality in the SUN (Seguimiento Universidad de Navarra) (Unive...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/3/972 |
| _version_ | 1797541014318088192 |
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| author | Susana Santiago Itziar Zazpe Cesar I. Fernandez-Lazaro Víctor de la O Maira Bes-Rastrollo Miguel Ángel Martínez-González |
| author_facet | Susana Santiago Itziar Zazpe Cesar I. Fernandez-Lazaro Víctor de la O Maira Bes-Rastrollo Miguel Ángel Martínez-González |
| author_sort | Susana Santiago |
| collection | DOAJ |
| description | No previous study has assessed the relationship between overall macronutrient quality and all-cause mortality. We aimed to prospectively examine the association between a multidimensional macronutrient quality index (MQI) and all-cause mortality in the SUN (Seguimiento Universidad de Navarra) (University of Navarra Follow-Up) study, a Mediterranean cohort of middle-aged adults. Dietary intake information was obtained from a validated 136-item semi-quantitative food-frequency questionnaire. We calculated the MQI (categorized in quartiles) based on three quality indexes: the carbohydrate quality index (CQI), the fat quality index (FQI), and the healthy plate protein source quality index (HPPQI). Among 19,083 participants (mean age 38.4, 59.9% female), 440 deaths from all causes were observed during a median follow-up of 12.2 years (IQR, 8.3–14.9). No significant association was found between the MQI and mortality risk with multivariable-adjusted hazard ratio (HR) for the highest vs. the lowest quartile of 0.79 (95% CI, 0.59–1.06; P<sub>trend</sub> = 0.199). The CQI was the only component of the MQI associated with mortality showing a significant inverse relationship, with HR between extreme quartiles of 0.64 (95% CI, 0.45–0.90; P<sub>trend</sub> = 0.021). In this Mediterranean cohort, a new and multidimensional MQI defined a priori was not associated with all-cause mortality. Among its three sub-indexes, only the CQI showed a significant inverse relationship with the risk of all-cause mortality. |
| first_indexed | 2024-03-10T13:09:18Z |
| format | Article |
| id | doaj.art-0a0230c93e144c88a55ff5236297fa7c |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T13:09:18Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-0a0230c93e144c88a55ff5236297fa7c2023-11-21T10:50:11ZengMDPI AGNutrients2072-66432021-03-0113397210.3390/nu13030972Macronutrient Quality and All-Cause Mortality in the SUN CohortSusana Santiago0Itziar Zazpe1Cesar I. Fernandez-Lazaro2Víctor de la O3Maira Bes-Rastrollo4Miguel Ángel Martínez-González5Department of Nutrition and Food Sciences and Physiology, Campus Universitario, School of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, SpainDepartment of Nutrition and Food Sciences and Physiology, Campus Universitario, School of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, SpainDepartment of Preventive Medicine and Public Health, Campus Universitario, School of Medicine, University of Navarra, 31008 Pamplona, SpainDepartment of Preventive Medicine and Public Health, Campus Universitario, School of Medicine, University of Navarra, 31008 Pamplona, SpainDepartment of Preventive Medicine and Public Health, Campus Universitario, School of Medicine, University of Navarra, 31008 Pamplona, SpainDepartment of Preventive Medicine and Public Health, Campus Universitario, School of Medicine, University of Navarra, 31008 Pamplona, SpainNo previous study has assessed the relationship between overall macronutrient quality and all-cause mortality. We aimed to prospectively examine the association between a multidimensional macronutrient quality index (MQI) and all-cause mortality in the SUN (Seguimiento Universidad de Navarra) (University of Navarra Follow-Up) study, a Mediterranean cohort of middle-aged adults. Dietary intake information was obtained from a validated 136-item semi-quantitative food-frequency questionnaire. We calculated the MQI (categorized in quartiles) based on three quality indexes: the carbohydrate quality index (CQI), the fat quality index (FQI), and the healthy plate protein source quality index (HPPQI). Among 19,083 participants (mean age 38.4, 59.9% female), 440 deaths from all causes were observed during a median follow-up of 12.2 years (IQR, 8.3–14.9). No significant association was found between the MQI and mortality risk with multivariable-adjusted hazard ratio (HR) for the highest vs. the lowest quartile of 0.79 (95% CI, 0.59–1.06; P<sub>trend</sub> = 0.199). The CQI was the only component of the MQI associated with mortality showing a significant inverse relationship, with HR between extreme quartiles of 0.64 (95% CI, 0.45–0.90; P<sub>trend</sub> = 0.021). In this Mediterranean cohort, a new and multidimensional MQI defined a priori was not associated with all-cause mortality. Among its three sub-indexes, only the CQI showed a significant inverse relationship with the risk of all-cause mortality.https://www.mdpi.com/2072-6643/13/3/972macronutrient qualitycarbohydratesfatproteinsSUN cohortall-cause mortality |
| spellingShingle | Susana Santiago Itziar Zazpe Cesar I. Fernandez-Lazaro Víctor de la O Maira Bes-Rastrollo Miguel Ángel Martínez-González Macronutrient Quality and All-Cause Mortality in the SUN Cohort Nutrients macronutrient quality carbohydrates fat proteins SUN cohort all-cause mortality |
| title | Macronutrient Quality and All-Cause Mortality in the SUN Cohort |
| title_full | Macronutrient Quality and All-Cause Mortality in the SUN Cohort |
| title_fullStr | Macronutrient Quality and All-Cause Mortality in the SUN Cohort |
| title_full_unstemmed | Macronutrient Quality and All-Cause Mortality in the SUN Cohort |
| title_short | Macronutrient Quality and All-Cause Mortality in the SUN Cohort |
| title_sort | macronutrient quality and all cause mortality in the sun cohort |
| topic | macronutrient quality carbohydrates fat proteins SUN cohort all-cause mortality |
| url | https://www.mdpi.com/2072-6643/13/3/972 |
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