Clinical efficacy of probiotics in prevention of infectious diseases among hospitalized patients in ICU and non‐ICU wards in clinical randomized trials: A systematic review
Abstract Background and Aims The present study aimed to review probiotics' clinical efficacy in preventing infectious diseases among hospitalized patients in ICU and non‐ICU wards. Methods A search of Medline, EMBASE, The Cochrane Library, Science Direct, Open Grey, and Google Scholar was condu...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-08-01
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| Series: | Health Science Reports |
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| Online Access: | https://doi.org/10.1002/hsr2.1469 |
| _version_ | 1827698817600847872 |
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| author | Atieh Darbandi Maryam Banar Maryam Koupaei Roghayeh Afifirad Parisa Asadollahi Elnaz Bafandeh Iraj Rasooli Amir Emamie Tahereh Navidifar Parviz Owlia |
| author_facet | Atieh Darbandi Maryam Banar Maryam Koupaei Roghayeh Afifirad Parisa Asadollahi Elnaz Bafandeh Iraj Rasooli Amir Emamie Tahereh Navidifar Parviz Owlia |
| author_sort | Atieh Darbandi |
| collection | DOAJ |
| description | Abstract Background and Aims The present study aimed to review probiotics' clinical efficacy in preventing infectious diseases among hospitalized patients in ICU and non‐ICU wards. Methods A search of Medline, EMBASE, The Cochrane Library, Science Direct, Open Grey, and Google Scholar was conducted for eligible publications from 2002 to 2020 following the requirements outlined in the PRISMA guideline. The search strategy was based on the combination of the following terms: “probiotics,” “prebiotics,” “synbiotics,” and “cross‐infection.” The logical operators “AND” (or the equivalent operator for the databases) and “OR” (e.g., probiotics OR prebiotics OR synbiotics) were used. Results The results indicated that the probiotic consumption caused a significant reduction in antibiotic‐associated diarrhea (AAD) and Clostridioides difficile infection (CDI) in 2/8 randomized clinical trials (RCTs) investigating AAD/CDI. Also, 5/12 clinical trials highlighted the considerable effects of probiotics on the reduction or prevention of ventilator associated pneumoniae (VAP), so the mean prevalence of VAP was lower in the probiotic group than in the placebo group. The total rate of nosocomial infections among preterm infants was nonsignificantly higher in the probiotic group compared to the control group. Conclusion This systematic review shows that the administration of probiotics has moderate preventive or mitigating effects on the occurrence of VAP in ICU patients, CDI, AAD, and nosocomial infections among children. Consequently, applying antibiotics along with the proper probiotic species can be advantageous. |
| first_indexed | 2024-03-10T13:37:24Z |
| format | Article |
| id | doaj.art-0a0448ef088d4bad8687c1a7a38d43cf |
| institution | Directory Open Access Journal |
| issn | 2398-8835 |
| language | English |
| last_indexed | 2024-03-10T13:37:24Z |
| publishDate | 2023-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj.art-0a0448ef088d4bad8687c1a7a38d43cf2023-11-21T06:37:12ZengWileyHealth Science Reports2398-88352023-08-0168n/an/a10.1002/hsr2.1469Clinical efficacy of probiotics in prevention of infectious diseases among hospitalized patients in ICU and non‐ICU wards in clinical randomized trials: A systematic reviewAtieh Darbandi0Maryam Banar1Maryam Koupaei2Roghayeh Afifirad3Parisa Asadollahi4Elnaz Bafandeh5Iraj Rasooli6Amir Emamie7Tahereh Navidifar8Parviz Owlia9Molecular Microbiology Research Center Shahed University Tehran IranDepartment of Pathobiology School of Public Health, Tehran University of Medical Sciences Tehran IranDepartment of Microbiology and Immunology School of Medicine, Kashan University of Medical Sciences Kashan IranDepartment of Microbiology School of Medicine, Tehran University of Medical Sciences Tehran IranDepartment of Microbiology Faculty of Medicine, Ilam University of Medical Sciences Ilam IranDepartment of Medical Biotechnology Faculty of Medicine, Lorestan University of Medical Sciences Khorramabad IranMolecular Microbiology Research Center, Faculty of Sciences Shahed University Tehran IranDepartment of Pathobiology School of Public Health, Tehran University of Medical Sciences Tehran IranDepartment of Basic Sciences Shoushtar Faculty of Medical Sciences Shoushtar IranMolecular Microbiology Research Center Shahed University Tehran IranAbstract Background and Aims The present study aimed to review probiotics' clinical efficacy in preventing infectious diseases among hospitalized patients in ICU and non‐ICU wards. Methods A search of Medline, EMBASE, The Cochrane Library, Science Direct, Open Grey, and Google Scholar was conducted for eligible publications from 2002 to 2020 following the requirements outlined in the PRISMA guideline. The search strategy was based on the combination of the following terms: “probiotics,” “prebiotics,” “synbiotics,” and “cross‐infection.” The logical operators “AND” (or the equivalent operator for the databases) and “OR” (e.g., probiotics OR prebiotics OR synbiotics) were used. Results The results indicated that the probiotic consumption caused a significant reduction in antibiotic‐associated diarrhea (AAD) and Clostridioides difficile infection (CDI) in 2/8 randomized clinical trials (RCTs) investigating AAD/CDI. Also, 5/12 clinical trials highlighted the considerable effects of probiotics on the reduction or prevention of ventilator associated pneumoniae (VAP), so the mean prevalence of VAP was lower in the probiotic group than in the placebo group. The total rate of nosocomial infections among preterm infants was nonsignificantly higher in the probiotic group compared to the control group. Conclusion This systematic review shows that the administration of probiotics has moderate preventive or mitigating effects on the occurrence of VAP in ICU patients, CDI, AAD, and nosocomial infections among children. Consequently, applying antibiotics along with the proper probiotic species can be advantageous.https://doi.org/10.1002/hsr2.1469antibiotic‐associated diarrheaClostridioides difficile infectionnosocomial infectionsprobioticventilator‐associated pneumonia |
| spellingShingle | Atieh Darbandi Maryam Banar Maryam Koupaei Roghayeh Afifirad Parisa Asadollahi Elnaz Bafandeh Iraj Rasooli Amir Emamie Tahereh Navidifar Parviz Owlia Clinical efficacy of probiotics in prevention of infectious diseases among hospitalized patients in ICU and non‐ICU wards in clinical randomized trials: A systematic review Health Science Reports antibiotic‐associated diarrhea Clostridioides difficile infection nosocomial infections probiotic ventilator‐associated pneumonia |
| title | Clinical efficacy of probiotics in prevention of infectious diseases among hospitalized patients in ICU and non‐ICU wards in clinical randomized trials: A systematic review |
| title_full | Clinical efficacy of probiotics in prevention of infectious diseases among hospitalized patients in ICU and non‐ICU wards in clinical randomized trials: A systematic review |
| title_fullStr | Clinical efficacy of probiotics in prevention of infectious diseases among hospitalized patients in ICU and non‐ICU wards in clinical randomized trials: A systematic review |
| title_full_unstemmed | Clinical efficacy of probiotics in prevention of infectious diseases among hospitalized patients in ICU and non‐ICU wards in clinical randomized trials: A systematic review |
| title_short | Clinical efficacy of probiotics in prevention of infectious diseases among hospitalized patients in ICU and non‐ICU wards in clinical randomized trials: A systematic review |
| title_sort | clinical efficacy of probiotics in prevention of infectious diseases among hospitalized patients in icu and non icu wards in clinical randomized trials a systematic review |
| topic | antibiotic‐associated diarrhea Clostridioides difficile infection nosocomial infections probiotic ventilator‐associated pneumonia |
| url | https://doi.org/10.1002/hsr2.1469 |
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