Joint hypermobility in children with and without functional constipation
Background: Previous studies report an association between joint hypermobility (JH), as a hallmark of connective tissue disorder, and autonomic dysfunction, digestive problems, and irritable bowel syndrome. However, its association with functional constipation (FC) has not been evaluated. This study...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2020-01-01
|
| Series: | Journal of Research in Medical Sciences |
| Subjects: | |
| Online Access: | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2020;volume=25;issue=1;spage=28;epage=28;aulast=Khorasgani |
| _version_ | 1818151414085451776 |
|---|---|
| author | Seyed Mohammadreza Fatemi Khorasgani Neda Ramezani Negar Ebrahimi Varnousfaderani |
| author_facet | Seyed Mohammadreza Fatemi Khorasgani Neda Ramezani Negar Ebrahimi Varnousfaderani |
| author_sort | Seyed Mohammadreza Fatemi Khorasgani |
| collection | DOAJ |
| description | Background: Previous studies report an association between joint hypermobility (JH), as a hallmark of connective tissue disorder, and autonomic dysfunction, digestive problems, and irritable bowel syndrome. However, its association with functional constipation (FC) has not been evaluated. This study is run and implemented to justify this theme/topic. Materials and Methods: In this case–control study among 200 subjects, 100 were of FC according to the ROME III Criteria (case group) and each child was matched for age and gender with a healthy control that did not meet criteria for FC (control group). The demographic information and JH were assessed and compared in both groups, through a physical examination according to the Beighton score. Results: A total of 200 children with a mean age of 6.2 ± 2.2 years constituted the statistical population. The prevalence of JH was assessed to establish the Beighton score (≥4 was considered JH). There was no significant difference in JH between children with and without FC, odds ratio (OR) 1.13 (95% confidence interval [CI]: 0.65–1.98, P = 0.669). There was no significant difference in terms of gender and age between the two groups (P = 0.887, P = 0.396, respectively). JH was not significantly associated with gender (P = 0.445) while significantly associated with age (P = 0.041). Furthermore, there was no significant association between JH and FC (P = 0.669). Following multivariate logistic regression analysis between the presence of JH as the dependent variable and the measured variables as the independent variables, only age had significant independent predictive values in the development of JH (P = 0.041, OR =0.88 [0.77–1]). The obtained adjusted OR in this study indicated that at each year age increase the JH risk decreased by 12%. Conclusion: Here, it is revealed that the relative frequency of JH in this age range, with and without FC, is not significantly different, and it is not significantly associated with gender while significantly associated with age. |
| first_indexed | 2024-12-11T13:38:26Z |
| format | Article |
| id | doaj.art-0a055426960f459abeb0afc762011c52 |
| institution | Directory Open Access Journal |
| issn | 1735-1995 1735-7136 |
| language | English |
| last_indexed | 2024-12-11T13:38:26Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj.art-0a055426960f459abeb0afc762011c522022-12-22T01:04:55ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362020-01-01251282810.4103/jrms.JRMS_881_19Joint hypermobility in children with and without functional constipationSeyed Mohammadreza Fatemi KhorasganiNeda RamezaniNegar Ebrahimi VarnousfaderaniBackground: Previous studies report an association between joint hypermobility (JH), as a hallmark of connective tissue disorder, and autonomic dysfunction, digestive problems, and irritable bowel syndrome. However, its association with functional constipation (FC) has not been evaluated. This study is run and implemented to justify this theme/topic. Materials and Methods: In this case–control study among 200 subjects, 100 were of FC according to the ROME III Criteria (case group) and each child was matched for age and gender with a healthy control that did not meet criteria for FC (control group). The demographic information and JH were assessed and compared in both groups, through a physical examination according to the Beighton score. Results: A total of 200 children with a mean age of 6.2 ± 2.2 years constituted the statistical population. The prevalence of JH was assessed to establish the Beighton score (≥4 was considered JH). There was no significant difference in JH between children with and without FC, odds ratio (OR) 1.13 (95% confidence interval [CI]: 0.65–1.98, P = 0.669). There was no significant difference in terms of gender and age between the two groups (P = 0.887, P = 0.396, respectively). JH was not significantly associated with gender (P = 0.445) while significantly associated with age (P = 0.041). Furthermore, there was no significant association between JH and FC (P = 0.669). Following multivariate logistic regression analysis between the presence of JH as the dependent variable and the measured variables as the independent variables, only age had significant independent predictive values in the development of JH (P = 0.041, OR =0.88 [0.77–1]). The obtained adjusted OR in this study indicated that at each year age increase the JH risk decreased by 12%. Conclusion: Here, it is revealed that the relative frequency of JH in this age range, with and without FC, is not significantly different, and it is not significantly associated with gender while significantly associated with age.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2020;volume=25;issue=1;spage=28;epage=28;aulast=Khorasganibeighton scorefunctional constipationfunctional gastrointestinal disorderjoint hypermobilityrelative frequency |
| spellingShingle | Seyed Mohammadreza Fatemi Khorasgani Neda Ramezani Negar Ebrahimi Varnousfaderani Joint hypermobility in children with and without functional constipation Journal of Research in Medical Sciences beighton score functional constipation functional gastrointestinal disorder joint hypermobility relative frequency |
| title | Joint hypermobility in children with and without functional constipation |
| title_full | Joint hypermobility in children with and without functional constipation |
| title_fullStr | Joint hypermobility in children with and without functional constipation |
| title_full_unstemmed | Joint hypermobility in children with and without functional constipation |
| title_short | Joint hypermobility in children with and without functional constipation |
| title_sort | joint hypermobility in children with and without functional constipation |
| topic | beighton score functional constipation functional gastrointestinal disorder joint hypermobility relative frequency |
| url | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2020;volume=25;issue=1;spage=28;epage=28;aulast=Khorasgani |
| work_keys_str_mv | AT seyedmohammadrezafatemikhorasgani jointhypermobilityinchildrenwithandwithoutfunctionalconstipation AT nedaramezani jointhypermobilityinchildrenwithandwithoutfunctionalconstipation AT negarebrahimivarnousfaderani jointhypermobilityinchildrenwithandwithoutfunctionalconstipation |