Do YOU know the Ki-67 index of your breast cancer patients? Knowledge of your institution’s Ki-67 index distribution and its robustness is essential for decision-making in early breast cancer
Objectives: The proliferative activity of the Ki-67 index is important in decision-making of adjuvant treatments in early breast cancer. Its reliability can be reduced by inter-observer variability. This analysis’ objective is to evaluate the robustness of Ki-67 values within one center over 5 years...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-06-01
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| Series: | Breast |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0960977620300849 |
| _version_ | 1828900726576775168 |
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| author | Angela Fischer Maranta Simon Broder Constanze Fritzsche Michael Knauer Beat Thürlimann Wolfram Jochum Thomas Ruhstaller |
| author_facet | Angela Fischer Maranta Simon Broder Constanze Fritzsche Michael Knauer Beat Thürlimann Wolfram Jochum Thomas Ruhstaller |
| author_sort | Angela Fischer Maranta |
| collection | DOAJ |
| description | Objectives: The proliferative activity of the Ki-67 index is important in decision-making of adjuvant treatments in early breast cancer. Its reliability can be reduced by inter-observer variability. This analysis’ objective is to evaluate the robustness of Ki-67 values within one center over 5 years and to compare its distribution with a published dataset. Materials and methods: Ki-67 indices of early breast cancers treated at St. Gallen Breast Center were collected (2010–2014; 1154 patients). Distribution of Ki-67 values was analyzed for each year, along with histologic subtype and grading. Tumors were classified into intrinsic subtypes using two definitions: 2013 St. Gallen Consensus and the refined definition by Maisonneuve (“Milano Group”). Our institution’s Ki-67 cut-off value was adjusted to obtain the same distribution of luminal subtypes as published data of the Milano Group. Results: Ki-67 index frequency distributions were comparable between years (mean 26–30%, median 22–26%). Shape and position of the distribution curves were nearly identical. Ki-67 values correlated with tumor grade (median Ki-67: G1: 12.0%, G2: 21%, G3: 38%). Standard deviation of Ki-67 increased with higher grading (G1: 6.9; G2: 9.2; G3: 18.2; p < 0.001). According to the 2013 definition (and refined definition respectively), there were 35% (41%) luminal A-like and 65% (59%) luminal B-like tumors. To obtain the same distribution as the Milano group, Ki-67 cut-off needed to be elevated to 22%. Conclusions: Ki-67 index assessment was comparable over many years. Knowledge of one’s institution’s Ki-67 value distribution is essential for clinical decision-making of adjuvant therapies in early breast cancer. |
| first_indexed | 2024-12-13T15:51:14Z |
| format | Article |
| id | doaj.art-0a0573cd948a43b3bacc4b949043aaeb |
| institution | Directory Open Access Journal |
| issn | 1532-3080 |
| language | English |
| last_indexed | 2024-12-13T15:51:14Z |
| publishDate | 2020-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Breast |
| spelling | doaj.art-0a0573cd948a43b3bacc4b949043aaeb2022-12-21T23:39:28ZengElsevierBreast1532-30802020-06-0151120126Do YOU know the Ki-67 index of your breast cancer patients? Knowledge of your institution’s Ki-67 index distribution and its robustness is essential for decision-making in early breast cancerAngela Fischer Maranta0Simon Broder1Constanze Fritzsche2Michael Knauer3Beat Thürlimann4Wolfram Jochum5Thomas Ruhstaller6Department of Oncology, St. Gallen Cantonal Hospital, Rorschacher Strasse 95, 9007, St. Gallen, Switzerland; Corresponding author. Department of Oncology, Graubünden Cantonal Hospital, Loëstrasse 170, 7000, Chur, Switzerland.Department of Oncology, St. Gallen Cantonal Hospital, Rorschacher Strasse 95, 9007, St. Gallen, SwitzerlandInstitute of Pathology, St. Gallen Cantonal Hospital, Rorschacher Strasse 95, 9007, St. Gallen, SwitzerlandBreast Center, St. Gallen Cantonal Hospital, Rorschacher Strasse 95, 9007, St. Gallen, SwitzerlandBreast Center, St. Gallen Cantonal Hospital, Rorschacher Strasse 95, 9007, St. Gallen, SwitzerlandInstitute of Pathology, St. Gallen Cantonal Hospital, Rorschacher Strasse 95, 9007, St. Gallen, SwitzerlandBreast Center, St. Gallen Cantonal Hospital, Rorschacher Strasse 95, 9007, St. Gallen, Switzerland; Faculty of Medicine, University of Basel, Petersplatz 1, 4001, Basel, SwitzerlandObjectives: The proliferative activity of the Ki-67 index is important in decision-making of adjuvant treatments in early breast cancer. Its reliability can be reduced by inter-observer variability. This analysis’ objective is to evaluate the robustness of Ki-67 values within one center over 5 years and to compare its distribution with a published dataset. Materials and methods: Ki-67 indices of early breast cancers treated at St. Gallen Breast Center were collected (2010–2014; 1154 patients). Distribution of Ki-67 values was analyzed for each year, along with histologic subtype and grading. Tumors were classified into intrinsic subtypes using two definitions: 2013 St. Gallen Consensus and the refined definition by Maisonneuve (“Milano Group”). Our institution’s Ki-67 cut-off value was adjusted to obtain the same distribution of luminal subtypes as published data of the Milano Group. Results: Ki-67 index frequency distributions were comparable between years (mean 26–30%, median 22–26%). Shape and position of the distribution curves were nearly identical. Ki-67 values correlated with tumor grade (median Ki-67: G1: 12.0%, G2: 21%, G3: 38%). Standard deviation of Ki-67 increased with higher grading (G1: 6.9; G2: 9.2; G3: 18.2; p < 0.001). According to the 2013 definition (and refined definition respectively), there were 35% (41%) luminal A-like and 65% (59%) luminal B-like tumors. To obtain the same distribution as the Milano group, Ki-67 cut-off needed to be elevated to 22%. Conclusions: Ki-67 index assessment was comparable over many years. Knowledge of one’s institution’s Ki-67 value distribution is essential for clinical decision-making of adjuvant therapies in early breast cancer.http://www.sciencedirect.com/science/article/pii/S0960977620300849Intrinsic subtypeLuminal typeKi-67Early breast cancer |
| spellingShingle | Angela Fischer Maranta Simon Broder Constanze Fritzsche Michael Knauer Beat Thürlimann Wolfram Jochum Thomas Ruhstaller Do YOU know the Ki-67 index of your breast cancer patients? Knowledge of your institution’s Ki-67 index distribution and its robustness is essential for decision-making in early breast cancer Breast Intrinsic subtype Luminal type Ki-67 Early breast cancer |
| title | Do YOU know the Ki-67 index of your breast cancer patients? Knowledge of your institution’s Ki-67 index distribution and its robustness is essential for decision-making in early breast cancer |
| title_full | Do YOU know the Ki-67 index of your breast cancer patients? Knowledge of your institution’s Ki-67 index distribution and its robustness is essential for decision-making in early breast cancer |
| title_fullStr | Do YOU know the Ki-67 index of your breast cancer patients? Knowledge of your institution’s Ki-67 index distribution and its robustness is essential for decision-making in early breast cancer |
| title_full_unstemmed | Do YOU know the Ki-67 index of your breast cancer patients? Knowledge of your institution’s Ki-67 index distribution and its robustness is essential for decision-making in early breast cancer |
| title_short | Do YOU know the Ki-67 index of your breast cancer patients? Knowledge of your institution’s Ki-67 index distribution and its robustness is essential for decision-making in early breast cancer |
| title_sort | do you know the ki 67 index of your breast cancer patients knowledge of your institution s ki 67 index distribution and its robustness is essential for decision making in early breast cancer |
| topic | Intrinsic subtype Luminal type Ki-67 Early breast cancer |
| url | http://www.sciencedirect.com/science/article/pii/S0960977620300849 |
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