Evidence of Isomerization in the Michael-Type Thiol-Maleimide Addition: Click Reaction between L-Cysteine and 6-Maleimidehexanoic Acid

Evidence of Isomerization in the Michael-Type Thiol-Maleimide Addition: Click Reaction between L-Cysteine and 6-Maleimidehexanoic Acid

The reaction between L-cysteine (Cys) and 6-maleimidohexanoic acid (Mhx) in an aqueous medium at different levels of pH was analyzed via RP-HPLC, finding the presence of two reaction products throughout the evaluated pH range. By means of solid-phase extraction (SPE), it was possible to separate the...

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Bibliographic Details
Main Authors: Víctor Alfonso Niño-Ramírez, Diego Sebastián Insuasty-Cepeda, Zuly Jenny Rivera-Monroy, Mauricio Maldonado
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Molecules
Subjects:
click reaction
Michael addition
thiol-maleimide addition
isomerization
Online Access:https://www.mdpi.com/1420-3049/27/16/5064

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