Identification of Novel Fibrosis Modifiers by In Vivo siRNA Silencing

Identification of Novel Fibrosis Modifiers by In Vivo siRNA Silencing

Fibrotic diseases contribute to 45% of deaths in the industrialized world, and therefore a better understanding of the pathophysiological mechanisms underlying tissue fibrosis is sorely needed. We aimed to identify novel modifiers of tissue fibrosis expressed by myofibroblasts and their progenitors...

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Main Authors: Elisabeth H. Vollmann, Lizhi Cao, Aldo Amatucci, Taylor Reynolds, Stefan Hamann, Isin Dalkilic-Liddle, Thomas O. Cameron, Markus Hossbach, Kevin J. Kauffman, Faryal F. Mir, Daniel G. Anderson, Tatiana Novobrantseva, Victor Koteliansky, Tatiana Kisseleva, David Brenner, Jeremy Duffield, Linda C. Burkly
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
fibrosis
myofibroblast
siRNA
LNP
in vivo gene silencing
Egr2
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117301646

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