Molecular Signature of Endometrial Cancer with Coexistent Adenomyosis: A Multicentric Exploratory Analysis
Adenomyosis has been associated with better survival outcomes in women with endometrial cancer. However, although the endometrial cancer patients’ risk stratification has been revolutionized by molecular findings, the impact of the molecular signature on the favorable prognosis of endometrial cancer...
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MDPI AG
2023-10-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/21/5208 |
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| author | Diego Raimondo Antonio Raffone Agnese Virgilio Stefano Ferla Manuela Maletta Daniele Neola Antonio Travaglino Roberto Paradisi Alicia Hernández Emanuela Spagnolo Virginia García-Pineda Jacopo Lenzi Maurizio Guida Paolo Casadio Renato Seracchioli |
| author_facet | Diego Raimondo Antonio Raffone Agnese Virgilio Stefano Ferla Manuela Maletta Daniele Neola Antonio Travaglino Roberto Paradisi Alicia Hernández Emanuela Spagnolo Virginia García-Pineda Jacopo Lenzi Maurizio Guida Paolo Casadio Renato Seracchioli |
| author_sort | Diego Raimondo |
| collection | DOAJ |
| description | Adenomyosis has been associated with better survival outcomes in women with endometrial cancer. However, although the endometrial cancer patients’ risk stratification has been revolutionized by molecular findings, the impact of the molecular signature on the favorable prognosis of endometrial cancer patients with coexistent adenomyosis is unknown. The aim of our study was to compare the prevalence of molecular groups at poor and intermediate prognosis between endometrial cancer patients with and without coexistent adenomyosis. A multicentric, observational, retrospective, cohort study was performed to assess the differences in the prevalence of p53-abnormal expression (p53-abn) and mismatch repair protein-deficient expression (MMR-d) signatures between endometrial cancer patients with and without coexistent adenomyosis. A total of 147 endometrial cancer patients were included in the study: 38 in the adenomyosis group and 109 in the no adenomyosis group. A total of 37 patients showed the MMR-d signature (12 in the adenomyosis group and 25 in the no adenomyosis group), while 12 showed the p53-abn signature (3 in the adenomyosis group and 9 in the no adenomyosis group). No significant difference was found in the prevalence of p53-abn (<i>p</i> = 1.000) and MMR-d (<i>p</i> = 0.2880) signatures between endometrial cancer patients with and without coexistent adenomyosis. In conclusion, the molecular signature does not appear to explain the better prognosis associated with coexistent adenomyosis in endometrial cancer patients. Further investigation of these findings is necessary through future larger studies. |
| first_indexed | 2024-03-11T11:32:17Z |
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| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T11:32:17Z |
| publishDate | 2023-10-01 |
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| series | Cancers |
| spelling | doaj.art-0a07bce883444738bfcf7bcc912f58c02023-11-10T15:00:14ZengMDPI AGCancers2072-66942023-10-011521520810.3390/cancers15215208Molecular Signature of Endometrial Cancer with Coexistent Adenomyosis: A Multicentric Exploratory AnalysisDiego Raimondo0Antonio Raffone1Agnese Virgilio2Stefano Ferla3Manuela Maletta4Daniele Neola5Antonio Travaglino6Roberto Paradisi7Alicia Hernández8Emanuela Spagnolo9Virginia García-Pineda10Jacopo Lenzi11Maurizio Guida12Paolo Casadio13Renato Seracchioli14Division of Gynecology and Human Reproduction Physiopathology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, 40138 Bologna, ItalyDivision of Gynecology and Human Reproduction Physiopathology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyDivision of Gynecology and Human Reproduction Physiopathology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyDivision of Gynecology and Human Reproduction Physiopathology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyGynecology and Obstetrics Unit, Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, 80138 Naples, ItalyUnit of Pathology, Department of Medicine and Technological Innovation, University of Insubria, 21100 Varese, ItalyDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, 40138 Bologna, ItalyDepartment of Gynecology, La Paz University Hospital, Hospital Universitario La Paz, Paseo de la Castellana, 261, 28046 Madrid, SpainDepartment of Gynecology, La Paz University Hospital, Hospital Universitario La Paz, Paseo de la Castellana, 261, 28046 Madrid, SpainDepartment of Gynecologic Oncology, La Paz University Hospital, Hospital Universitario La Paz, Paseo de la Castellana, 261, 28046 Madrid, SpainDepartment of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, ItalyGynecology and Obstetrics Unit, Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, 80138 Naples, ItalyDivision of Gynecology and Human Reproduction Physiopathology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyDivision of Gynecology and Human Reproduction Physiopathology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyAdenomyosis has been associated with better survival outcomes in women with endometrial cancer. However, although the endometrial cancer patients’ risk stratification has been revolutionized by molecular findings, the impact of the molecular signature on the favorable prognosis of endometrial cancer patients with coexistent adenomyosis is unknown. The aim of our study was to compare the prevalence of molecular groups at poor and intermediate prognosis between endometrial cancer patients with and without coexistent adenomyosis. A multicentric, observational, retrospective, cohort study was performed to assess the differences in the prevalence of p53-abnormal expression (p53-abn) and mismatch repair protein-deficient expression (MMR-d) signatures between endometrial cancer patients with and without coexistent adenomyosis. A total of 147 endometrial cancer patients were included in the study: 38 in the adenomyosis group and 109 in the no adenomyosis group. A total of 37 patients showed the MMR-d signature (12 in the adenomyosis group and 25 in the no adenomyosis group), while 12 showed the p53-abn signature (3 in the adenomyosis group and 9 in the no adenomyosis group). No significant difference was found in the prevalence of p53-abn (<i>p</i> = 1.000) and MMR-d (<i>p</i> = 0.2880) signatures between endometrial cancer patients with and without coexistent adenomyosis. In conclusion, the molecular signature does not appear to explain the better prognosis associated with coexistent adenomyosis in endometrial cancer patients. Further investigation of these findings is necessary through future larger studies.https://www.mdpi.com/2072-6694/15/21/5208endometrial carcinomamolecular patterntumorprognosisneoplasmmalignancy |
| spellingShingle | Diego Raimondo Antonio Raffone Agnese Virgilio Stefano Ferla Manuela Maletta Daniele Neola Antonio Travaglino Roberto Paradisi Alicia Hernández Emanuela Spagnolo Virginia García-Pineda Jacopo Lenzi Maurizio Guida Paolo Casadio Renato Seracchioli Molecular Signature of Endometrial Cancer with Coexistent Adenomyosis: A Multicentric Exploratory Analysis Cancers endometrial carcinoma molecular pattern tumor prognosis neoplasm malignancy |
| title | Molecular Signature of Endometrial Cancer with Coexistent Adenomyosis: A Multicentric Exploratory Analysis |
| title_full | Molecular Signature of Endometrial Cancer with Coexistent Adenomyosis: A Multicentric Exploratory Analysis |
| title_fullStr | Molecular Signature of Endometrial Cancer with Coexistent Adenomyosis: A Multicentric Exploratory Analysis |
| title_full_unstemmed | Molecular Signature of Endometrial Cancer with Coexistent Adenomyosis: A Multicentric Exploratory Analysis |
| title_short | Molecular Signature of Endometrial Cancer with Coexistent Adenomyosis: A Multicentric Exploratory Analysis |
| title_sort | molecular signature of endometrial cancer with coexistent adenomyosis a multicentric exploratory analysis |
| topic | endometrial carcinoma molecular pattern tumor prognosis neoplasm malignancy |
| url | https://www.mdpi.com/2072-6694/15/21/5208 |
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