Asymptomatic stenosis of carotid arteries: novel view on the problem
For the assessment of factors promoting progression of atherosclerosis of the carotid arteries (CA), we performed a detailed clinical-laboratory and instrumental comparison of the two groups of patients – with asymptomatic CA stenosis and with ischemic stroke resulted from stenosis of the CA. Progre...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Research Center of Neurology
2017-02-01
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| Series: | Анналы клинической и экспериментальной неврологии |
| Subjects: | |
| Online Access: | https://annaly-nevrologii.com/journal/pathID/article/viewFile/376/274 |
| _version_ | 1828815083406360576 |
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| author | M. M. Tanashyan O. V. Lagoda I. S. Klimenko N. A. Glotova A. O. Chechetkin A. V. Fonyakin R. N. Konovalov |
| author_facet | M. M. Tanashyan O. V. Lagoda I. S. Klimenko N. A. Glotova A. O. Chechetkin A. V. Fonyakin R. N. Konovalov |
| author_sort | M. M. Tanashyan |
| collection | DOAJ |
| description | For the assessment of factors promoting progression of atherosclerosis of the carotid arteries (CA), we performed a detailed clinical-laboratory and instrumental comparison of the two groups of patients – with asymptomatic CA stenosis and with ischemic stroke resulted from stenosis of the CA. Progression of atherosclerotic damage of the CA was shown to be related with the following factors: а) severity of hemorheologic changes (including iatrogenic resistance to antiagregating drugs); b) presence of endothelial dysfunction; c) increase of the level of immunohistochemical markers of angiogenesis (molecules of intercellular adhesion sICAM21 and sРЕCAM21); d) the state of central hemodynamics and cerebral perfusion. The obtained data help to individualize medical and prophylactic procedures, select a group of patients with the high risk of ischemic stroke and clarify indications to reconstructive angioneurosurgical operations. |
| first_indexed | 2024-12-12T10:37:51Z |
| format | Article |
| id | doaj.art-0a0800d551184fbc97b07e06d0af9fcd |
| institution | Directory Open Access Journal |
| issn | 2075-5473 2409-2533 |
| language | English |
| last_indexed | 2024-12-12T10:37:51Z |
| publishDate | 2017-02-01 |
| publisher | Research Center of Neurology |
| record_format | Article |
| series | Анналы клинической и экспериментальной неврологии |
| spelling | doaj.art-0a0800d551184fbc97b07e06d0af9fcd2022-12-22T00:27:08ZengResearch Center of NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-25332017-02-0132172010.17816/psaic376274Asymptomatic stenosis of carotid arteries: novel view on the problemM. M. Tanashyan0O. V. Lagoda1I. S. Klimenko2N. A. Glotova3A. O. Chechetkin4A. V. Fonyakin5R. N. Konovalov6Research Center of Neurology, Russian Academy of Medical Sciences, MoscowResearch Center of Neurology, Russian Academy of Medical Sciences, MoscowResearch Center of Neurology, Russian Academy of Medical Sciences, MoscowResearch Center of Neurology, Russian Academy of Medical Sciences, MoscowResearch Center of Neurology, Russian Academy of Medical Sciences, MoscowResearch Center of Neurology, Russian Academy of Medical Sciences, MoscowResearch Center of Neurology, Russian Academy of Medical Sciences, MoscowFor the assessment of factors promoting progression of atherosclerosis of the carotid arteries (CA), we performed a detailed clinical-laboratory and instrumental comparison of the two groups of patients – with asymptomatic CA stenosis and with ischemic stroke resulted from stenosis of the CA. Progression of atherosclerotic damage of the CA was shown to be related with the following factors: а) severity of hemorheologic changes (including iatrogenic resistance to antiagregating drugs); b) presence of endothelial dysfunction; c) increase of the level of immunohistochemical markers of angiogenesis (molecules of intercellular adhesion sICAM21 and sРЕCAM21); d) the state of central hemodynamics and cerebral perfusion. The obtained data help to individualize medical and prophylactic procedures, select a group of patients with the high risk of ischemic stroke and clarify indications to reconstructive angioneurosurgical operations.https://annaly-nevrologii.com/journal/pathID/article/viewFile/376/274carotid arteriesasymptomatic stenosisatherosclerotic plaquehemorheologycentral and cerebral hemodynamicsendothelial dysfunction |
| spellingShingle | M. M. Tanashyan O. V. Lagoda I. S. Klimenko N. A. Glotova A. O. Chechetkin A. V. Fonyakin R. N. Konovalov Asymptomatic stenosis of carotid arteries: novel view on the problem Анналы клинической и экспериментальной неврологии carotid arteries asymptomatic stenosis atherosclerotic plaque hemorheology central and cerebral hemodynamics endothelial dysfunction |
| title | Asymptomatic stenosis of carotid arteries: novel view on the problem |
| title_full | Asymptomatic stenosis of carotid arteries: novel view on the problem |
| title_fullStr | Asymptomatic stenosis of carotid arteries: novel view on the problem |
| title_full_unstemmed | Asymptomatic stenosis of carotid arteries: novel view on the problem |
| title_short | Asymptomatic stenosis of carotid arteries: novel view on the problem |
| title_sort | asymptomatic stenosis of carotid arteries novel view on the problem |
| topic | carotid arteries asymptomatic stenosis atherosclerotic plaque hemorheology central and cerebral hemodynamics endothelial dysfunction |
| url | https://annaly-nevrologii.com/journal/pathID/article/viewFile/376/274 |
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