The spleen is the graveyard of CD4+ cells in patients with immunological failure of visceral leishmaniasis and AIDS

The spleen is the graveyard of CD4+ cells in patients with immunological failure of visceral leishmaniasis and AIDS

Abstract Background Visceral leishmaniasis (VL), or kala-azar, is a common comorbidity in patients with AIDS in endemic areas. Many patients continue to experiences relapses of VL despite virological control, but with immunological failure. These patients remain chronically symptomatic with hyperspl...

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Bibliographic Details
Main Authors: Luis Gustavo Cavalcante Reinaldo, Raimundo José Cunha Araújo Júnior, Thiago Melo Diniz, Rafael de Deus Moura, Antônio José Meneses Filho, Caio Victor Verçosa de Macedo Furtado, Washington Luis Conrado dos Santos, Dorcas Lamounier Costa, Kelsen Dantas Eulálio, Gabriel R. Ferreira, Carlos Henrique Nery Costa
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Parasites & Vectors
Subjects:
Visceral leishmaniasis
Kala-azar
Leishmania infantum
Hypersplenism
AIDS
T-lymphocytes
Online Access:https://doi.org/10.1186/s13071-024-06151-6

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