The Local Environment of Loop Switch 1 Modulates the Rate of ATP-Induced Dissociation of Human Cardiac Actomyosin

The Local Environment of Loop Switch 1 Modulates the Rate of ATP-Induced Dissociation of Human Cardiac Actomyosin

Two isoforms of human cardiac myosin, alpha and beta, share significant sequence similarities but show different kinetics. The alpha isoform is a faster motor; it spends less time being strongly bound to actin during the actomyosin cycle. With alpha isoform, actomyosin dissociates faster upon ATP bi...

Full description

Bibliographic Details
Main Authors: Akhil Gargey, Yuri E. Nesmelov
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
human cardiac myosin
loop switch 1
loop switch 2
P-loop
ATP
ADP
Online Access:https://www.mdpi.com/1422-0067/23/3/1220

Similar Items

Similar Items