Сommission test of Effectiveness of the supramolecular complex based on triclabendazole and albendazole at Fasciolosis and gastrointestinal strongylatosis of sheep
The purpose of the research is a commission test of the effectiveness of the supramolecular complex based on triclabendazole and albendazole (SMCTA) against gastrointestinal nematodes and fascioles of sheep in a previously calculated therapeutic dose.Materials and methods. The SMCTA effectiveness wa...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Federal Scientific Centre VIEV
2020-06-01
|
| Series: | Российский паразитологический журнал |
| Subjects: | |
| Online Access: | https://vniigis.elpub.ru/jour/article/view/602 |
| _version_ | 1826570028792676352 |
|---|---|
| author | E. V. Lagereva V. E. Abramov M. B. Musayev Sh. V. Vatsayev A. Z. Dzhamalova Kh. Kh. Shakhbiyev |
| author_facet | E. V. Lagereva V. E. Abramov M. B. Musayev Sh. V. Vatsayev A. Z. Dzhamalova Kh. Kh. Shakhbiyev |
| author_sort | E. V. Lagereva |
| collection | DOAJ |
| description | The purpose of the research is a commission test of the effectiveness of the supramolecular complex based on triclabendazole and albendazole (SMCTA) against gastrointestinal nematodes and fascioles of sheep in a previously calculated therapeutic dose.Materials and methods. The SMCTA effectiveness was tested in the North Caucasus Federal District in July 2019 on Tushin sheep spontaneously infected with gastrointestinal nematodes and fascioles simultaneously. The sheep were owned by an independent entrepreneur. Coproovoscopic examinations were carried out according to the GOST by the Fulleborn’s method using ammonium nitrate at the Republican Veterinary Laboratory of Grozny. Helminthological dissection of 5 control sheep was done to determine the intensity of infection with fascioles and gastrointestinal nematodes, and 3 sheep from each group were dissected at 14 days after dehelminthization to record the effectiveness of the drug. 4 more sheep from each group were dissected on the 25th day. The drug effectiveness was recorded by the critical test method according to the Guidelines approved by the World Association for the Advancement of Veterinary Parasitology (1995).Results and discussion. When conducting clinical trials on sheep spontaneously infected with strongylates of the gastrointestinal tract and lungs, and fascioles, a therapeutic dose was calculated when the drug was administered individually in the form of a suspension of 4.0 mg/kg for the Active Substance (2.0 for ABZ : 2.0 for TCB), 40 mg/kg for the drug, and in a mixture with concentrated feed using the group method of 5.0 mg/kg for the AS (2.5 mg/kg for ABZ : 2.5 mg/kg for TCB), 50 mg/kg for the drug. The commission test of SMCTA at a dose of 5.0 mg/kg for the AS (50 mg/kg for the drug) by the group method in a mixture with combined feed at fasciolosis and strongylatosis of the gastrointestinal tract of sheep showed, according to the coproovoscopy and helminthological dissection of animals, that 100 % efficiency was obtained. A mixture of the drug with combined feed was readily eaten by the sheep; and no side effects were noted after dehelminthization. The Commission noted the absence of side effects, high efficiency and a wide spectrum of the SMKTA effect at a 4-fold reduced therapeutic dose of 5.0 mg/kg as compared with the albendazole (7.5 mg/kg) and triclabendazole (10 mg/kg) substances. |
| first_indexed | 2024-03-08T21:40:42Z |
| format | Article |
| id | doaj.art-0a0a666c45564f9a867e2fc7a3de8dfd |
| institution | Directory Open Access Journal |
| issn | 1998-8435 2541-7843 |
| language | Russian |
| last_indexed | 2025-03-14T11:48:43Z |
| publishDate | 2020-06-01 |
| publisher | Federal Scientific Centre VIEV |
| record_format | Article |
| series | Российский паразитологический журнал |
| spelling | doaj.art-0a0a666c45564f9a867e2fc7a3de8dfd2025-03-02T09:49:57ZrusFederal Scientific Centre VIEVРоссийский паразитологический журнал1998-84352541-78432020-06-011429810210.31016/1998-8435-2020-14-2-98-102585Сommission test of Effectiveness of the supramolecular complex based on triclabendazole and albendazole at Fasciolosis and gastrointestinal strongylatosis of sheepE. V. Lagereva0V. E. Abramov1M. B. Musayev2Sh. V. Vatsayev3A. Z. Dzhamalova4Kh. Kh. Shakhbiyev5All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants – a branch of Federal State Budgetary Institution of Science "Federal Scientific Center – All-Russian Scientific Research Institute of Experimental Veterinary Medicine named after K. I. Skryabin and Ya. R. Kovalenko of the Russian Academy of Sciences"All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants – a branch of Federal State Budgetary Institution of Science "Federal Scientific Center – All-Russian Scientific Research Institute of Experimental Veterinary Medicine named after K. I. Skryabin and Ya. R. Kovalenko of the Russian Academy of Sciences"All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants – a branch of Federal State Budgetary Institution of Science "Federal Scientific Center – All-Russian Scientific Research Institute of Experimental Veterinary Medicine named after K. I. Skryabin and Ya. R. Kovalenko of the Russian Academy of Sciences"Agrotechnological Institute of the Chechen State UniversityKh. I. Ibragimov Complex Research Institute, RASAgrotechnological Institute of the Chechen State UniversityThe purpose of the research is a commission test of the effectiveness of the supramolecular complex based on triclabendazole and albendazole (SMCTA) against gastrointestinal nematodes and fascioles of sheep in a previously calculated therapeutic dose.Materials and methods. The SMCTA effectiveness was tested in the North Caucasus Federal District in July 2019 on Tushin sheep spontaneously infected with gastrointestinal nematodes and fascioles simultaneously. The sheep were owned by an independent entrepreneur. Coproovoscopic examinations were carried out according to the GOST by the Fulleborn’s method using ammonium nitrate at the Republican Veterinary Laboratory of Grozny. Helminthological dissection of 5 control sheep was done to determine the intensity of infection with fascioles and gastrointestinal nematodes, and 3 sheep from each group were dissected at 14 days after dehelminthization to record the effectiveness of the drug. 4 more sheep from each group were dissected on the 25th day. The drug effectiveness was recorded by the critical test method according to the Guidelines approved by the World Association for the Advancement of Veterinary Parasitology (1995).Results and discussion. When conducting clinical trials on sheep spontaneously infected with strongylates of the gastrointestinal tract and lungs, and fascioles, a therapeutic dose was calculated when the drug was administered individually in the form of a suspension of 4.0 mg/kg for the Active Substance (2.0 for ABZ : 2.0 for TCB), 40 mg/kg for the drug, and in a mixture with concentrated feed using the group method of 5.0 mg/kg for the AS (2.5 mg/kg for ABZ : 2.5 mg/kg for TCB), 50 mg/kg for the drug. The commission test of SMCTA at a dose of 5.0 mg/kg for the AS (50 mg/kg for the drug) by the group method in a mixture with combined feed at fasciolosis and strongylatosis of the gastrointestinal tract of sheep showed, according to the coproovoscopy and helminthological dissection of animals, that 100 % efficiency was obtained. A mixture of the drug with combined feed was readily eaten by the sheep; and no side effects were noted after dehelminthization. The Commission noted the absence of side effects, high efficiency and a wide spectrum of the SMKTA effect at a 4-fold reduced therapeutic dose of 5.0 mg/kg as compared with the albendazole (7.5 mg/kg) and triclabendazole (10 mg/kg) substances.https://vniigis.elpub.ru/jour/article/view/602supramolecular complexalbendazoletriclabendazolepolyvinylpyrrolidonestrongylatosisfasciolosissheep |
| spellingShingle | E. V. Lagereva V. E. Abramov M. B. Musayev Sh. V. Vatsayev A. Z. Dzhamalova Kh. Kh. Shakhbiyev Сommission test of Effectiveness of the supramolecular complex based on triclabendazole and albendazole at Fasciolosis and gastrointestinal strongylatosis of sheep Российский паразитологический журнал supramolecular complex albendazole triclabendazole polyvinylpyrrolidone strongylatosis fasciolosis sheep |
| title | Сommission test of Effectiveness of the supramolecular complex based on triclabendazole and albendazole at Fasciolosis and gastrointestinal strongylatosis of sheep |
| title_full | Сommission test of Effectiveness of the supramolecular complex based on triclabendazole and albendazole at Fasciolosis and gastrointestinal strongylatosis of sheep |
| title_fullStr | Сommission test of Effectiveness of the supramolecular complex based on triclabendazole and albendazole at Fasciolosis and gastrointestinal strongylatosis of sheep |
| title_full_unstemmed | Сommission test of Effectiveness of the supramolecular complex based on triclabendazole and albendazole at Fasciolosis and gastrointestinal strongylatosis of sheep |
| title_short | Сommission test of Effectiveness of the supramolecular complex based on triclabendazole and albendazole at Fasciolosis and gastrointestinal strongylatosis of sheep |
| title_sort | сommission test of effectiveness of the supramolecular complex based on triclabendazole and albendazole at fasciolosis and gastrointestinal strongylatosis of sheep |
| topic | supramolecular complex albendazole triclabendazole polyvinylpyrrolidone strongylatosis fasciolosis sheep |
| url | https://vniigis.elpub.ru/jour/article/view/602 |
| work_keys_str_mv | AT evlagereva sommissiontestofeffectivenessofthesupramolecularcomplexbasedontriclabendazoleandalbendazoleatfasciolosisandgastrointestinalstrongylatosisofsheep AT veabramov sommissiontestofeffectivenessofthesupramolecularcomplexbasedontriclabendazoleandalbendazoleatfasciolosisandgastrointestinalstrongylatosisofsheep AT mbmusayev sommissiontestofeffectivenessofthesupramolecularcomplexbasedontriclabendazoleandalbendazoleatfasciolosisandgastrointestinalstrongylatosisofsheep AT shvvatsayev sommissiontestofeffectivenessofthesupramolecularcomplexbasedontriclabendazoleandalbendazoleatfasciolosisandgastrointestinalstrongylatosisofsheep AT azdzhamalova sommissiontestofeffectivenessofthesupramolecularcomplexbasedontriclabendazoleandalbendazoleatfasciolosisandgastrointestinalstrongylatosisofsheep AT khkhshakhbiyev sommissiontestofeffectivenessofthesupramolecularcomplexbasedontriclabendazoleandalbendazoleatfasciolosisandgastrointestinalstrongylatosisofsheep |