Hepatitis C Virus Infection and Intrinsic Disorder in the Signaling Pathways Induced by Toll-Like Receptors
In this study, we examined the interplay between protein intrinsic disorder, hepatitis C virus (HCV) infection, and signaling pathways induced by Toll-like receptors (TLRs). To this end, 10 HCV proteins, 10 human TLRs, and 41 proteins from the TLR-induced downstream pathways were considered from the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/11/7/1091 |
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| author | Elrashdy M. Redwan Abdullah A. Aljadawi Vladimir N. Uversky |
| author_facet | Elrashdy M. Redwan Abdullah A. Aljadawi Vladimir N. Uversky |
| author_sort | Elrashdy M. Redwan |
| collection | DOAJ |
| description | In this study, we examined the interplay between protein intrinsic disorder, hepatitis C virus (HCV) infection, and signaling pathways induced by Toll-like receptors (TLRs). To this end, 10 HCV proteins, 10 human TLRs, and 41 proteins from the TLR-induced downstream pathways were considered from the prevalence of intrinsic disorder. Mapping of the intrinsic disorder to the HCV-TLR interactome and to the TLR-based pathways of human innate immune response to the HCV infection demonstrates that substantial levels of intrinsic disorder are characteristic for proteins involved in the regulation and execution of these innate immunity pathways and in HCV-TLR interaction. Disordered regions, being commonly enriched in sites of various posttranslational modifications, may play important functional roles by promoting protein–protein interactions and support the binding of the analyzed proteins to other partners such as nucleic acids. It seems that this system represents an important illustration of the role of intrinsic disorder in virus–host warfare. |
| first_indexed | 2024-03-09T03:41:04Z |
| format | Article |
| id | doaj.art-0a0bcb9456bd47c5af0cec387e453b13 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-09T03:41:04Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-0a0bcb9456bd47c5af0cec387e453b132023-12-03T14:41:00ZengMDPI AGBiology2079-77372022-07-01117109110.3390/biology11071091Hepatitis C Virus Infection and Intrinsic Disorder in the Signaling Pathways Induced by Toll-Like ReceptorsElrashdy M. Redwan0Abdullah A. Aljadawi1Vladimir N. Uversky2Biological Science Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi ArabiaBiological Science Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi ArabiaBiological Science Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi ArabiaIn this study, we examined the interplay between protein intrinsic disorder, hepatitis C virus (HCV) infection, and signaling pathways induced by Toll-like receptors (TLRs). To this end, 10 HCV proteins, 10 human TLRs, and 41 proteins from the TLR-induced downstream pathways were considered from the prevalence of intrinsic disorder. Mapping of the intrinsic disorder to the HCV-TLR interactome and to the TLR-based pathways of human innate immune response to the HCV infection demonstrates that substantial levels of intrinsic disorder are characteristic for proteins involved in the regulation and execution of these innate immunity pathways and in HCV-TLR interaction. Disordered regions, being commonly enriched in sites of various posttranslational modifications, may play important functional roles by promoting protein–protein interactions and support the binding of the analyzed proteins to other partners such as nucleic acids. It seems that this system represents an important illustration of the role of intrinsic disorder in virus–host warfare.https://www.mdpi.com/2079-7737/11/7/1091intrinsically disordered regionintrinsically disordered proteinhepatitis C virustoll-like receptorsprotein–protein interactionsdisorder-to-order transition |
| spellingShingle | Elrashdy M. Redwan Abdullah A. Aljadawi Vladimir N. Uversky Hepatitis C Virus Infection and Intrinsic Disorder in the Signaling Pathways Induced by Toll-Like Receptors Biology intrinsically disordered region intrinsically disordered protein hepatitis C virus toll-like receptors protein–protein interactions disorder-to-order transition |
| title | Hepatitis C Virus Infection and Intrinsic Disorder in the Signaling Pathways Induced by Toll-Like Receptors |
| title_full | Hepatitis C Virus Infection and Intrinsic Disorder in the Signaling Pathways Induced by Toll-Like Receptors |
| title_fullStr | Hepatitis C Virus Infection and Intrinsic Disorder in the Signaling Pathways Induced by Toll-Like Receptors |
| title_full_unstemmed | Hepatitis C Virus Infection and Intrinsic Disorder in the Signaling Pathways Induced by Toll-Like Receptors |
| title_short | Hepatitis C Virus Infection and Intrinsic Disorder in the Signaling Pathways Induced by Toll-Like Receptors |
| title_sort | hepatitis c virus infection and intrinsic disorder in the signaling pathways induced by toll like receptors |
| topic | intrinsically disordered region intrinsically disordered protein hepatitis C virus toll-like receptors protein–protein interactions disorder-to-order transition |
| url | https://www.mdpi.com/2079-7737/11/7/1091 |
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