Structure-guided engineering of immunotherapies targeting TRBC1 and TRBC2 in T cell malignancies

Structure-guided engineering of immunotherapies targeting TRBC1 and TRBC2 in T cell malignancies

Abstract Peripheral T cell lymphomas are typically aggressive with a poor prognosis. Unlike other hematologic malignancies, the lack of target antigens to discriminate healthy from malignant cells limits the efficacy of immunotherapeutic approaches. The T cell receptor expresses one of two highly ho...

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التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Mathieu Ferrari, Matteo Righi, Vania Baldan, Patrycja Wawrzyniecka, Anna Bulek, Alexander Kinna, Biao Ma, Reyisa Bughda, Zulaikha Akbar, Saket Srivastava, Isaac Gannon, Mathew Robson, James Sillibourne, Ram Jha, Mohamed El-Kholy, Oliver Muhammad Amin, Evangelia Kokalaki, Mohammed Amin Banani, Rehan Hussain, William Day, Wen Chean Lim, Priyanka Ghongane, Jade R. Hopkins, Dennis Jungherz, Marco Herling, Martin Welin, Sachin Surade, Michael Dyson, John McCafferty, Derek Logan, Shaun Cordoba, Simon Thomas, Andrew Sewell, Paul Maciocia, Shimobi Onuoha, Martin Pule
التنسيق: مقال
اللغة:English
منشور في: Nature Portfolio 2024-02-01
سلاسل:Nature Communications
الوصول للمادة أونلاين:https://doi.org/10.1038/s41467-024-45854-3

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