TRIM3 and TRIM16 as potential tumor suppressors in breast cancer patients
Abstract Objective Breast cancer is the leading cause of death among women in many countries. Numerous factors serve as oncogenes or tumor suppressors in breast cancer. The large family of Tripartite-motif (TRIM) proteins with ~ 80 members has drawn attention for their role in cancer. TRIM3 and TRIM...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | BMC Research Notes |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13104-022-06193-y |
| _version_ | 1797998555391066112 |
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| author | Mohammad Reza Roshanazadeh Maryam Adelipour Arash Sanaei Hadi Chenane Mojtaba Rashidi |
| author_facet | Mohammad Reza Roshanazadeh Maryam Adelipour Arash Sanaei Hadi Chenane Mojtaba Rashidi |
| author_sort | Mohammad Reza Roshanazadeh |
| collection | DOAJ |
| description | Abstract Objective Breast cancer is the leading cause of death among women in many countries. Numerous factors serve as oncogenes or tumor suppressors in breast cancer. The large family of Tripartite-motif (TRIM) proteins with ~ 80 members has drawn attention for their role in cancer. TRIM3 and TRIM16 have shown suppressive activity in different cancers. This study aimed to evaluate the expression of TRIM3 and TRIM16 in cancerous and normal breast samples and to investigate their association with different clinical and pathological parameters. Results qRT-PCR was utilized to determine the gene expression of TRIM3 and TRIM16. The expression of TRIM3 and TRIM16 genes in tumor samples were significantly reduced to 0.45 and 0.29 fold, respectively. TRIM3 and TRIM16 genes expression were both positively correlated with the invasion of breast cancer. TRIM3 gene expression was associated with tumors’ histological grade. However, no significant association was found between the expression of the genes and tumor size, stage and necrosis. The expression of TRIM3 and TRIM16 are significantly reduced in breast cancer tissues. Besides, the expression of both TRIM3 and TRIM16 genes significantly plummet in lymphatic/vascular and perineural invasive samples. Hence, we suggest a potential tumor suppressor role for TRIM3 and TRIM16 in breast cancer. |
| first_indexed | 2024-04-11T10:50:36Z |
| format | Article |
| id | doaj.art-0a0d13901b22472eac029745f33900a2 |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-04-11T10:50:36Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-0a0d13901b22472eac029745f33900a22022-12-22T04:28:55ZengBMCBMC Research Notes1756-05002022-09-011511710.1186/s13104-022-06193-yTRIM3 and TRIM16 as potential tumor suppressors in breast cancer patientsMohammad Reza Roshanazadeh0Maryam Adelipour1Arash Sanaei2Hadi Chenane3Mojtaba Rashidi4Cancer Research Center, Ahvaz Jundishapur University of Medical SciencesDepartment of clinical biochemistry, Faculty of medicine, jundishapour University of medical sciencesDepartment of clinical biochemistry, Faculty of medicine, jundishapour University of medical sciencesDepartment of clinical biochemistry, Faculty of medicine, jundishapour University of medical sciencesCancer Research Center, Ahvaz Jundishapur University of Medical SciencesAbstract Objective Breast cancer is the leading cause of death among women in many countries. Numerous factors serve as oncogenes or tumor suppressors in breast cancer. The large family of Tripartite-motif (TRIM) proteins with ~ 80 members has drawn attention for their role in cancer. TRIM3 and TRIM16 have shown suppressive activity in different cancers. This study aimed to evaluate the expression of TRIM3 and TRIM16 in cancerous and normal breast samples and to investigate their association with different clinical and pathological parameters. Results qRT-PCR was utilized to determine the gene expression of TRIM3 and TRIM16. The expression of TRIM3 and TRIM16 genes in tumor samples were significantly reduced to 0.45 and 0.29 fold, respectively. TRIM3 and TRIM16 genes expression were both positively correlated with the invasion of breast cancer. TRIM3 gene expression was associated with tumors’ histological grade. However, no significant association was found between the expression of the genes and tumor size, stage and necrosis. The expression of TRIM3 and TRIM16 are significantly reduced in breast cancer tissues. Besides, the expression of both TRIM3 and TRIM16 genes significantly plummet in lymphatic/vascular and perineural invasive samples. Hence, we suggest a potential tumor suppressor role for TRIM3 and TRIM16 in breast cancer.https://doi.org/10.1186/s13104-022-06193-yTRIM3TRIM16Breast cancerTumor suppressorInvasion |
| spellingShingle | Mohammad Reza Roshanazadeh Maryam Adelipour Arash Sanaei Hadi Chenane Mojtaba Rashidi TRIM3 and TRIM16 as potential tumor suppressors in breast cancer patients BMC Research Notes TRIM3 TRIM16 Breast cancer Tumor suppressor Invasion |
| title | TRIM3 and TRIM16 as potential tumor suppressors in breast cancer patients |
| title_full | TRIM3 and TRIM16 as potential tumor suppressors in breast cancer patients |
| title_fullStr | TRIM3 and TRIM16 as potential tumor suppressors in breast cancer patients |
| title_full_unstemmed | TRIM3 and TRIM16 as potential tumor suppressors in breast cancer patients |
| title_short | TRIM3 and TRIM16 as potential tumor suppressors in breast cancer patients |
| title_sort | trim3 and trim16 as potential tumor suppressors in breast cancer patients |
| topic | TRIM3 TRIM16 Breast cancer Tumor suppressor Invasion |
| url | https://doi.org/10.1186/s13104-022-06193-y |
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