Serum Uric Acid but Not Ferritin Level Is Associated with Hepatic Fibrosis in Lean Subjects with Metabolic Dysfunction-Associated Fatty Liver Disease: A Community-Based Study
Elevated serum ferritin and uric acid levels are common in patients with fatty liver disease. This study assessed the association between serum ferritin and uric acid levels and liver fibrosis in subjects with lean metabolic dysfunction-associated fatty liver disease (MAFLD). This cross-sectional st...
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MDPI AG
2022-12-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/12/2009 |
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| author | Cheng-Han Xie Li-Wei Chen Chih-Lang Lin Ching-Chih Hu Cheng-Hung Chien |
| author_facet | Cheng-Han Xie Li-Wei Chen Chih-Lang Lin Ching-Chih Hu Cheng-Hung Chien |
| author_sort | Cheng-Han Xie |
| collection | DOAJ |
| description | Elevated serum ferritin and uric acid levels are common in patients with fatty liver disease. This study assessed the association between serum ferritin and uric acid levels and liver fibrosis in subjects with lean metabolic dysfunction-associated fatty liver disease (MAFLD). This cross-sectional study used data from a community screening examination for metabolic syndrome from December 2018 to September 2019 at Keelung Chang Gung Memorial Hospital. Subjects with lean MAFLD were defined as those with a body mass index (BMI) < 23 kg/m<sup>2</sup> and hepatic steatosis according to the MAFLD criteria. A total of 182 lean subjects were included and were divided into lean MAFLD and lean healthy groups. Serum ferritin and uric acid concentrations were positively correlated with liver fibrosis, regardless of whether FIB-4, APRI, or NFS were used as references. Univariate logistic regression analysis showed that age and uric acid were associated with advanced liver fibrosis. After adjusting for potential confounders, only uric acid level was statistically significant in predicting the advanced liver fibrosis (OR = 6.907 (1.111–42.94), <i>p</i> = 0.038) in the lean MAFLD group. We found that an elevated serum uric acid level is an independent factor associated with advanced liver fibrosis in lean MAFLD subjects by noninvasive fibrosis scores. |
| first_indexed | 2024-03-09T16:12:35Z |
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| id | doaj.art-0a0dc8f3300a471caa5dbaa236f00398 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T16:12:35Z |
| publishDate | 2022-12-01 |
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| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-0a0dc8f3300a471caa5dbaa236f003982023-11-24T16:02:04ZengMDPI AGJournal of Personalized Medicine2075-44262022-12-011212200910.3390/jpm12122009Serum Uric Acid but Not Ferritin Level Is Associated with Hepatic Fibrosis in Lean Subjects with Metabolic Dysfunction-Associated Fatty Liver Disease: A Community-Based StudyCheng-Han Xie0Li-Wei Chen1Chih-Lang Lin2Ching-Chih Hu3Cheng-Hung Chien4Department of Gastroenterology and Hepatology, Chang-Gung Memorial Hospital and University, Keelung 204, TaiwanDepartment of Gastroenterology and Hepatology, Chang-Gung Memorial Hospital and University, Keelung 204, TaiwanDepartment of Gastroenterology and Hepatology, Chang-Gung Memorial Hospital and University, Keelung 204, TaiwanDepartment of Gastroenterology and Hepatology, Chang-Gung Memorial Hospital and University, Keelung 204, TaiwanDepartment of Gastroenterology and Hepatology, Chang-Gung Memorial Hospital and University, Keelung 204, TaiwanElevated serum ferritin and uric acid levels are common in patients with fatty liver disease. This study assessed the association between serum ferritin and uric acid levels and liver fibrosis in subjects with lean metabolic dysfunction-associated fatty liver disease (MAFLD). This cross-sectional study used data from a community screening examination for metabolic syndrome from December 2018 to September 2019 at Keelung Chang Gung Memorial Hospital. Subjects with lean MAFLD were defined as those with a body mass index (BMI) < 23 kg/m<sup>2</sup> and hepatic steatosis according to the MAFLD criteria. A total of 182 lean subjects were included and were divided into lean MAFLD and lean healthy groups. Serum ferritin and uric acid concentrations were positively correlated with liver fibrosis, regardless of whether FIB-4, APRI, or NFS were used as references. Univariate logistic regression analysis showed that age and uric acid were associated with advanced liver fibrosis. After adjusting for potential confounders, only uric acid level was statistically significant in predicting the advanced liver fibrosis (OR = 6.907 (1.111–42.94), <i>p</i> = 0.038) in the lean MAFLD group. We found that an elevated serum uric acid level is an independent factor associated with advanced liver fibrosis in lean MAFLD subjects by noninvasive fibrosis scores.https://www.mdpi.com/2075-4426/12/12/2009leanmetabolic dysfunction-associated fatty liver diseaseliver fibrosisserum uric acidserum ferritinliver steatosis |
| spellingShingle | Cheng-Han Xie Li-Wei Chen Chih-Lang Lin Ching-Chih Hu Cheng-Hung Chien Serum Uric Acid but Not Ferritin Level Is Associated with Hepatic Fibrosis in Lean Subjects with Metabolic Dysfunction-Associated Fatty Liver Disease: A Community-Based Study Journal of Personalized Medicine lean metabolic dysfunction-associated fatty liver disease liver fibrosis serum uric acid serum ferritin liver steatosis |
| title | Serum Uric Acid but Not Ferritin Level Is Associated with Hepatic Fibrosis in Lean Subjects with Metabolic Dysfunction-Associated Fatty Liver Disease: A Community-Based Study |
| title_full | Serum Uric Acid but Not Ferritin Level Is Associated with Hepatic Fibrosis in Lean Subjects with Metabolic Dysfunction-Associated Fatty Liver Disease: A Community-Based Study |
| title_fullStr | Serum Uric Acid but Not Ferritin Level Is Associated with Hepatic Fibrosis in Lean Subjects with Metabolic Dysfunction-Associated Fatty Liver Disease: A Community-Based Study |
| title_full_unstemmed | Serum Uric Acid but Not Ferritin Level Is Associated with Hepatic Fibrosis in Lean Subjects with Metabolic Dysfunction-Associated Fatty Liver Disease: A Community-Based Study |
| title_short | Serum Uric Acid but Not Ferritin Level Is Associated with Hepatic Fibrosis in Lean Subjects with Metabolic Dysfunction-Associated Fatty Liver Disease: A Community-Based Study |
| title_sort | serum uric acid but not ferritin level is associated with hepatic fibrosis in lean subjects with metabolic dysfunction associated fatty liver disease a community based study |
| topic | lean metabolic dysfunction-associated fatty liver disease liver fibrosis serum uric acid serum ferritin liver steatosis |
| url | https://www.mdpi.com/2075-4426/12/12/2009 |
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