Metformin Prevents Key Mechanisms of Obesity-Related Complications in Visceral White Adipose Tissue of Obese Pregnant Mice

Metformin Prevents Key Mechanisms of Obesity-Related Complications in Visceral White Adipose Tissue of Obese Pregnant Mice

With the gaining prevalence of obesity, related risks during pregnancy are rising. Inflammation and oxidative stress are considered key mechanisms arising in white adipose tissue (WAT) sparking obesity-associated complications and diseases. The established anti-diabetic drug metformin reduces both o...

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Bibliographic Details
Main Authors: Katrin Schmitz, Eva-Maria Turnwald, Tobias Kretschmer, Ruth Janoschek, Inga Bae-Gartz, Kathrin Voßbrecher, Merlin D. Kammerer, Angela Köninger, Alexandra Gellhaus, Marion Handwerk, Maria Wohlfarth, Dirk Gründemann, Eva Hucklenbruch-Rother, Jörg Dötsch, Sarah Appel
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Nutrients
Subjects:
metformin
maternal obesity
pregnancy complications
white adipose tissue
adipokines
inflammation
Online Access:https://www.mdpi.com/2072-6643/14/11/2288

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