Return to Work, Fatigue and Cancer Rehabilitation after Curative Radiotherapy and Radiochemotherapy for Pelvic Gynecologic Cancer
Pain, fatigue, and depression are a common cluster of symptoms among cancer patients that impair quality of life and daily activities. We aimed to evaluate the burden of cancer rehabilitation and return-to-work (RTW) rates. Tumor characteristics, lifestyle and household details, treatment data, the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/9/2330 |
| _version_ | 1797505298012831744 |
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| author | Eva Meixner Elisabetta Sandrini Line Hoeltgen Tanja Eichkorn Philipp Hoegen Laila König Nathalie Arians Jonathan W. Lischalk Markus Wallwiener Ilse Weis Daniela Roob Jürgen Debus Juliane Hörner-Rieber |
| author_facet | Eva Meixner Elisabetta Sandrini Line Hoeltgen Tanja Eichkorn Philipp Hoegen Laila König Nathalie Arians Jonathan W. Lischalk Markus Wallwiener Ilse Weis Daniela Roob Jürgen Debus Juliane Hörner-Rieber |
| author_sort | Eva Meixner |
| collection | DOAJ |
| description | Pain, fatigue, and depression are a common cluster of symptoms among cancer patients that impair quality of life and daily activities. We aimed to evaluate the burden of cancer rehabilitation and return-to-work (RTW) rates. Tumor characteristics, lifestyle and household details, treatment data, the use of in-house social services and post-treatment inpatient rehabilitation, and RTW were assessed for 424 women, diagnosed with cervical, uterine, or vaginal/vulvar cancer, receiving curative radio(chemo)therapy. Progression-free RTW rate at 3 months was 32.3%, and increased to 58.1% and 63.2% at 12 and 18 months, respectively. Patients with advanced FIGO stages and intensified treatments significantly suffered more from acute pain and fatigue. A higher Charlson-Comorbidity-Index reliably predicted patients associated with a higher risk of acute fatigue during RT. Aside from the presence of children, no other household or lifestyle factor was correlated with increased fatigue rates. Women aged ≤ 45 years had a significantly higher risk of developing depression requiring treatment during follow-up. Post-treatment inpatient cancer rehabilitation, including exercise and nutrition counseling, significantly relieved fatigue symptoms. The burdens for recovery from cancer therapy remain multi-factorial. Special focus needs to be placed on identifying high-risk groups experiencing fatigue or pain. Specialized post-treatment inpatient cancer rehabilitation can improve RTW rates. |
| first_indexed | 2024-03-10T04:16:37Z |
| format | Article |
| id | doaj.art-0a0eaec500c64fd2945347d1aae10b65 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T04:16:37Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-0a0eaec500c64fd2945347d1aae10b652023-11-23T07:58:06ZengMDPI AGCancers2072-66942022-05-01149233010.3390/cancers14092330Return to Work, Fatigue and Cancer Rehabilitation after Curative Radiotherapy and Radiochemotherapy for Pelvic Gynecologic CancerEva Meixner0Elisabetta Sandrini1Line Hoeltgen2Tanja Eichkorn3Philipp Hoegen4Laila König5Nathalie Arians6Jonathan W. Lischalk7Markus Wallwiener8Ilse Weis9Daniela Roob10Jürgen Debus11Juliane Hörner-Rieber12Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, GermanyDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, GermanyDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, GermanyDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, GermanyDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, GermanyDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, GermanyDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, GermanyDepartment of Radiation Oncology, Perlmutter Cancer Center, New York University Langone Health, New York, NY 10023, USADepartment of Gynecology and Obstetrics, Heidelberg University Hospital, 69120 Heidelberg, GermanySocial Service Counselling, University Hospital Heidelberg, 69120 Heidelberg, GermanySocial Service Counselling, University Hospital Heidelberg, 69120 Heidelberg, GermanyDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, GermanyDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, GermanyPain, fatigue, and depression are a common cluster of symptoms among cancer patients that impair quality of life and daily activities. We aimed to evaluate the burden of cancer rehabilitation and return-to-work (RTW) rates. Tumor characteristics, lifestyle and household details, treatment data, the use of in-house social services and post-treatment inpatient rehabilitation, and RTW were assessed for 424 women, diagnosed with cervical, uterine, or vaginal/vulvar cancer, receiving curative radio(chemo)therapy. Progression-free RTW rate at 3 months was 32.3%, and increased to 58.1% and 63.2% at 12 and 18 months, respectively. Patients with advanced FIGO stages and intensified treatments significantly suffered more from acute pain and fatigue. A higher Charlson-Comorbidity-Index reliably predicted patients associated with a higher risk of acute fatigue during RT. Aside from the presence of children, no other household or lifestyle factor was correlated with increased fatigue rates. Women aged ≤ 45 years had a significantly higher risk of developing depression requiring treatment during follow-up. Post-treatment inpatient cancer rehabilitation, including exercise and nutrition counseling, significantly relieved fatigue symptoms. The burdens for recovery from cancer therapy remain multi-factorial. Special focus needs to be placed on identifying high-risk groups experiencing fatigue or pain. Specialized post-treatment inpatient cancer rehabilitation can improve RTW rates.https://www.mdpi.com/2072-6694/14/9/2330endometrial cancerdefinitive radiotherapyadjuvant chemoradiationtoxicity |
| spellingShingle | Eva Meixner Elisabetta Sandrini Line Hoeltgen Tanja Eichkorn Philipp Hoegen Laila König Nathalie Arians Jonathan W. Lischalk Markus Wallwiener Ilse Weis Daniela Roob Jürgen Debus Juliane Hörner-Rieber Return to Work, Fatigue and Cancer Rehabilitation after Curative Radiotherapy and Radiochemotherapy for Pelvic Gynecologic Cancer Cancers endometrial cancer definitive radiotherapy adjuvant chemoradiation toxicity |
| title | Return to Work, Fatigue and Cancer Rehabilitation after Curative Radiotherapy and Radiochemotherapy for Pelvic Gynecologic Cancer |
| title_full | Return to Work, Fatigue and Cancer Rehabilitation after Curative Radiotherapy and Radiochemotherapy for Pelvic Gynecologic Cancer |
| title_fullStr | Return to Work, Fatigue and Cancer Rehabilitation after Curative Radiotherapy and Radiochemotherapy for Pelvic Gynecologic Cancer |
| title_full_unstemmed | Return to Work, Fatigue and Cancer Rehabilitation after Curative Radiotherapy and Radiochemotherapy for Pelvic Gynecologic Cancer |
| title_short | Return to Work, Fatigue and Cancer Rehabilitation after Curative Radiotherapy and Radiochemotherapy for Pelvic Gynecologic Cancer |
| title_sort | return to work fatigue and cancer rehabilitation after curative radiotherapy and radiochemotherapy for pelvic gynecologic cancer |
| topic | endometrial cancer definitive radiotherapy adjuvant chemoradiation toxicity |
| url | https://www.mdpi.com/2072-6694/14/9/2330 |
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