<i>Per1/Per2</i> Disruption Reduces Testosterone Synthesis and Impairs Fertility in Elderly Male Mice

<i>Per1/Per2</i> Disruption Reduces Testosterone Synthesis and Impairs Fertility in Elderly Male Mice

Circadian rhythm disorders caused by genetic or environmental factors lead to decreased male fertility but the mechanisms are poorly understood. The current study reports that the mechanism of <i>Per1/Per2</i> Double knockout (DKO) reduced the reproductive capacity of elderly male mice....

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Bibliographic Details
Main Authors: Qinrui Liu, Hu Wang, Hualin Wang, Na Li, Ruyi He, Zhiguo Liu
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
circadian clock
<i>Per1/Per2</i>
fertility
testosterone synthesis
sperm motility
Online Access:https://www.mdpi.com/1422-0067/23/13/7399

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