Ultrasound-assisted one-pot three-component synthesis of new isoxazolines bearing sulfonamides and their evaluation against hematological malignancies

Ultrasound-assisted one-pot three-component synthesis of new isoxazolines bearing sulfonamides and their evaluation against hematological malignancies

In the present study, following a one-pot two-step protocol, we have synthesized novel sulfonamides-isoxazolines hybrids (3a-r) via a highly regioselective 1,3-dipolar cycloaddition. The present methodology capitalized on trichloroisocyanuric acid (TCCA) as a safe and ecological oxidant and chlorina...

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Bibliographic Details
Main Authors: Aicha Talha, Cécile Favreau, Maxence Bourgoin, Guillaume Robert, Patrick Auberger, Lahcen EL Ammari, Mohamed Saadi, Rachid Benhida, Anthony R. Martin, Khalid Bougrin
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Ultrasonics Sonochemistry
Subjects:
Sulfonamides-Isoxazolines
One-pot synthesis
Radical processes
Ultrasound
Hematological Malignancies
Online Access:http://www.sciencedirect.com/science/article/pii/S135041772100290X

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