Anti-Hyperuricemic and Nephroprotective Effects of Dihydroberberine in Potassium Oxonate- and Hypoxanthine-Induced Hyperuricemic Mice

Anti-Hyperuricemic and Nephroprotective Effects of Dihydroberberine in Potassium Oxonate- and Hypoxanthine-Induced Hyperuricemic Mice

Phellodendri Chinese Cortex has long been used to treat hyperuricemia and gout. Berberine (BBR), its characteristic ingredient, has also been shown to be effective in alleviating monosodium urate crystals-triggered gout inflammation in vitro and in vivo. Dihydroberberine (DHB) is a hydrogenated deri...

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Bibliographic Details
Main Authors: Lieqiang Xu, Guoshu Lin, Qiuxia Yu, Qiaoping Li, Liting Mai, Juanjuan Cheng, Jianhui Xie, Yuhong Liu, Ziren Su, Yucui Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
hyperuricemia
inflammation
xanthine oxidase
NLRP3 inflammasome
urate transporters
dihydroberberine
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.645879/full

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