Meta-analysis of the association between angiotensin II receptor, type 1 gene A1166C polymorphism and coronary artery disease in Chinese populations
Background and objective: Many studies have examined the association between the angiotensin II receptor, type 1 ( AGTR1 ) gene A1166C polymorphism and coronary artery disease (CAD); the results, however, remain controversial. Given the accumulation of data, we conducted a meta-analysis of published...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publications
2013-03-01
|
| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320312450599 |
| Summary: | Background and objective: Many studies have examined the association between the angiotensin II receptor, type 1 ( AGTR1 ) gene A1166C polymorphism and coronary artery disease (CAD); the results, however, remain controversial. Given the accumulation of data, we conducted a meta-analysis of published studies on this association in Chinese. Methods and results: A comprehensive search of PubMed, Wanfang and Chinese National Knowledge Infrastructure (CNKI) databases was conducted before January 2012. Data and study quality were assessed in duplicate. Twenty-two studies totaling 3502 CAD patients and 3071 controls were analyzed. Overall, individuals carrying 1166C allele had a remarkably increased risk of CAD compared with those with 1166AA genotype (odds ratio (OR)=1.63; 95% confidence interval (CI): 1.26-2.1; P <0.0005). In subgroup analyses by geography, the risk magnitude was slightly augmented in northern Chinese (OR=1.76; 95% CI: 1.23-2.52; P =0.002) relative to in southern Chinese (OR=1.55; 95% CI: 1.13-2.14; P =0.007). Grouping studies by average age detected a strong association in studies involving CAD patients aged ≥ 60 years. Differences in the diagnosis of CAD and source of controls might be potential sources of between-study heterogeneity. Conclusions: Our findings provided strong evidence that AGTR1 gene A1166C polymorphism might be a genetic marker for the development of CAD in Chinese populations, especially in the context of studies with northern and older subjects. |
|---|---|
| ISSN: | 1470-3203 1752-8976 |