Bacteria and Bacterial Components as Natural Bio-Nanocarriers for Drug and Gene Delivery Systems in Cancer Therapy
Bacteria and bacterial components possess multifunctional properties, making them attractive natural bio-nanocarriers for cancer diagnosis and targeted treatment. The inherent tropic and motile nature of bacteria allows them to grow and colonize in hypoxic tumor microenvironments more readily than c...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/15/10/2490 |
| _version_ | 1797572506497843200 |
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| author | Rui Zong Hainan Ruan Chanmin Liu Shaohua Fan Jun Li |
| author_facet | Rui Zong Hainan Ruan Chanmin Liu Shaohua Fan Jun Li |
| author_sort | Rui Zong |
| collection | DOAJ |
| description | Bacteria and bacterial components possess multifunctional properties, making them attractive natural bio-nanocarriers for cancer diagnosis and targeted treatment. The inherent tropic and motile nature of bacteria allows them to grow and colonize in hypoxic tumor microenvironments more readily than conventional therapeutic agents and other nanomedicines. However, concerns over biosafety, limited antitumor efficiency, and unclear tumor-targeting mechanisms have restricted the clinical translation and application of natural bio-nanocarriers based on bacteria and bacterial components. Fortunately, bacterial therapies combined with engineering strategies and nanotechnology may be able to reverse a number of challenges for bacterial/bacterial component-based cancer biotherapies. Meanwhile, the combined strategies tend to enhance the versatility of bionanoplasmic nanoplatforms to improve biosafety and inhibit tumorigenesis and metastasis. This review summarizes the advantages and challenges of bacteria and bacterial components in cancer therapy, outlines combinatorial strategies for nanocarriers and bacterial/bacterial components, and discusses their clinical applications. |
| first_indexed | 2024-03-10T20:57:14Z |
| format | Article |
| id | doaj.art-0a15fbc6d221484b9fadd5473548586b |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T20:57:14Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-0a15fbc6d221484b9fadd5473548586b2023-11-19T17:45:16ZengMDPI AGPharmaceutics1999-49232023-10-011510249010.3390/pharmaceutics15102490Bacteria and Bacterial Components as Natural Bio-Nanocarriers for Drug and Gene Delivery Systems in Cancer TherapyRui Zong0Hainan Ruan1Chanmin Liu2Shaohua Fan3Jun Li4School of Life Science, Jiangsu Normal University, Xuzhou 221116, ChinaSchool of Life Science, Jiangsu Normal University, Xuzhou 221116, ChinaSchool of Life Science, Jiangsu Normal University, Xuzhou 221116, ChinaSchool of Life Science, Jiangsu Normal University, Xuzhou 221116, ChinaSchool of Life Science, Jiangsu Normal University, Xuzhou 221116, ChinaBacteria and bacterial components possess multifunctional properties, making them attractive natural bio-nanocarriers for cancer diagnosis and targeted treatment. The inherent tropic and motile nature of bacteria allows them to grow and colonize in hypoxic tumor microenvironments more readily than conventional therapeutic agents and other nanomedicines. However, concerns over biosafety, limited antitumor efficiency, and unclear tumor-targeting mechanisms have restricted the clinical translation and application of natural bio-nanocarriers based on bacteria and bacterial components. Fortunately, bacterial therapies combined with engineering strategies and nanotechnology may be able to reverse a number of challenges for bacterial/bacterial component-based cancer biotherapies. Meanwhile, the combined strategies tend to enhance the versatility of bionanoplasmic nanoplatforms to improve biosafety and inhibit tumorigenesis and metastasis. This review summarizes the advantages and challenges of bacteria and bacterial components in cancer therapy, outlines combinatorial strategies for nanocarriers and bacterial/bacterial components, and discusses their clinical applications.https://www.mdpi.com/1999-4923/15/10/2490bacteriabacterial componentsbiomimetic nanoplatformstumor targetinggene therapyengineered strategies |
| spellingShingle | Rui Zong Hainan Ruan Chanmin Liu Shaohua Fan Jun Li Bacteria and Bacterial Components as Natural Bio-Nanocarriers for Drug and Gene Delivery Systems in Cancer Therapy Pharmaceutics bacteria bacterial components biomimetic nanoplatforms tumor targeting gene therapy engineered strategies |
| title | Bacteria and Bacterial Components as Natural Bio-Nanocarriers for Drug and Gene Delivery Systems in Cancer Therapy |
| title_full | Bacteria and Bacterial Components as Natural Bio-Nanocarriers for Drug and Gene Delivery Systems in Cancer Therapy |
| title_fullStr | Bacteria and Bacterial Components as Natural Bio-Nanocarriers for Drug and Gene Delivery Systems in Cancer Therapy |
| title_full_unstemmed | Bacteria and Bacterial Components as Natural Bio-Nanocarriers for Drug and Gene Delivery Systems in Cancer Therapy |
| title_short | Bacteria and Bacterial Components as Natural Bio-Nanocarriers for Drug and Gene Delivery Systems in Cancer Therapy |
| title_sort | bacteria and bacterial components as natural bio nanocarriers for drug and gene delivery systems in cancer therapy |
| topic | bacteria bacterial components biomimetic nanoplatforms tumor targeting gene therapy engineered strategies |
| url | https://www.mdpi.com/1999-4923/15/10/2490 |
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