Diagnostic efficacy of contrast-enhanced gastric ultrasonography in staging gastric cancer: a meta-analysis
Abstract Background As comprehensive surgical management for gastric cancer becomes increasingly specialized and standardized, the precise differentiation between ≤T1 and ≥T2 gastric cancer before endoscopic intervention holds paramount clinical significance. Objective To evaluate the diagnostic eff...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-024-12210-z |
| _version_ | 1797219709773414400 |
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| author | Yuan Zhong Yan-Yan Xiao Jie-Yi Ye Guo-Liang Jian Wei-Jun Huang |
| author_facet | Yuan Zhong Yan-Yan Xiao Jie-Yi Ye Guo-Liang Jian Wei-Jun Huang |
| author_sort | Yuan Zhong |
| collection | DOAJ |
| description | Abstract Background As comprehensive surgical management for gastric cancer becomes increasingly specialized and standardized, the precise differentiation between ≤T1 and ≥T2 gastric cancer before endoscopic intervention holds paramount clinical significance. Objective To evaluate the diagnostic efficacy of contrast-enhanced gastric ultrasonography in differentiating ≤T1 and ≥T2 gastric cancer. Methods PubMed, Web of Science, and Medline were searched to collect studies published from January 1, 2000 to March 16, 2023 on the efficacy of either double contrast-enhanced gastric ultrasonography (D-CEGUS) or oral contrast-enhanced gastric ultrasonography (O-CEGUS) in determining T-stage in gastric cancer. The articles were selected according to specified inclusion and exclusion criteria, and the quality of the included literature was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 scale. Meta-analysis was performed using Stata 12 software with data from the 2 × 2 crosslinked tables in the included literature. Results In total, 11 papers with 1124 patients were included in the O-CEGUS analysis, which revealed a combined sensitivity of 0.822 (95% confidence interval [CI] = 0.753–0.875), combined specificity of 0.964 (95% CI = 0.925–0.983), and area under the summary receiver operating characteristic (sROC) curve (AUC) of 0.92 (95% CI = 0.89–0.94). In addition, five studies involving 536 patients were included in the D-CEGUS analysis, which gave a combined sensitivity of 0.733 (95% CI = 0.550–0.860), combined specificity of 0.982 (95% CI = 0.936–0.995), and AUC of 0.93 (95% CI = 0.91–0.95). According to the I2 and P values of the forest plot, there was obvious heterogeneity in the combined specificities of the included papers. Therefore, the two studies with the lowest specificities were excluded from the O-CEGUS and D-CEGUS analyses, which eliminated the heterogeneity among the remaining literature. Consequently, the combined sensitivity and specificity of the remaining studies were 0.794 (95% CI = 0.710–0.859) and 0.976 (95% CI = 0.962–0.985), respectively, for the O-CEDUS studies and 0.765 (95% CI = 0.543–0.899) and 0.986 (95% CI = 0.967–0.994), respectively, for the D-CEGUS studies. The AUCs were 0.98 and 0.99 for O-CEGUS and D-CEGUS studies, respectively. Conclusion Both O-CEGUS and D-CEGUS can differentiate ≤T1 gastric cancer from ≥T2 gastric cancer, thus assisting the formulation of clinical treatment strategies for patients with very early gastric cancer. Given its simplicity and cost-effectiveness, O-CEGUS is often favored as a staging method for gastric cancer prior to endoscopic intervention. |
| first_indexed | 2024-04-24T12:37:58Z |
| format | Article |
| id | doaj.art-0a16293fd87d4c49ab7fdbe04eb36000 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-24T12:37:58Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-0a16293fd87d4c49ab7fdbe04eb360002024-04-07T11:21:38ZengBMCBMC Cancer1471-24072024-04-0124111310.1186/s12885-024-12210-zDiagnostic efficacy of contrast-enhanced gastric ultrasonography in staging gastric cancer: a meta-analysisYuan Zhong0Yan-Yan Xiao1Jie-Yi Ye2Guo-Liang Jian3Wei-Jun Huang4Department of Medical Ultrasound, The First People’s Hospital of FoshanDepartment of Medical Ultrasound, The First People’s Hospital of FoshanDepartment of Medical Ultrasound, The First People’s Hospital of FoshanDepartment of Medical Ultrasound, The First People’s Hospital of FoshanDepartment of Medical Ultrasound, The First People’s Hospital of FoshanAbstract Background As comprehensive surgical management for gastric cancer becomes increasingly specialized and standardized, the precise differentiation between ≤T1 and ≥T2 gastric cancer before endoscopic intervention holds paramount clinical significance. Objective To evaluate the diagnostic efficacy of contrast-enhanced gastric ultrasonography in differentiating ≤T1 and ≥T2 gastric cancer. Methods PubMed, Web of Science, and Medline were searched to collect studies published from January 1, 2000 to March 16, 2023 on the efficacy of either double contrast-enhanced gastric ultrasonography (D-CEGUS) or oral contrast-enhanced gastric ultrasonography (O-CEGUS) in determining T-stage in gastric cancer. The articles were selected according to specified inclusion and exclusion criteria, and the quality of the included literature was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 scale. Meta-analysis was performed using Stata 12 software with data from the 2 × 2 crosslinked tables in the included literature. Results In total, 11 papers with 1124 patients were included in the O-CEGUS analysis, which revealed a combined sensitivity of 0.822 (95% confidence interval [CI] = 0.753–0.875), combined specificity of 0.964 (95% CI = 0.925–0.983), and area under the summary receiver operating characteristic (sROC) curve (AUC) of 0.92 (95% CI = 0.89–0.94). In addition, five studies involving 536 patients were included in the D-CEGUS analysis, which gave a combined sensitivity of 0.733 (95% CI = 0.550–0.860), combined specificity of 0.982 (95% CI = 0.936–0.995), and AUC of 0.93 (95% CI = 0.91–0.95). According to the I2 and P values of the forest plot, there was obvious heterogeneity in the combined specificities of the included papers. Therefore, the two studies with the lowest specificities were excluded from the O-CEGUS and D-CEGUS analyses, which eliminated the heterogeneity among the remaining literature. Consequently, the combined sensitivity and specificity of the remaining studies were 0.794 (95% CI = 0.710–0.859) and 0.976 (95% CI = 0.962–0.985), respectively, for the O-CEDUS studies and 0.765 (95% CI = 0.543–0.899) and 0.986 (95% CI = 0.967–0.994), respectively, for the D-CEGUS studies. The AUCs were 0.98 and 0.99 for O-CEGUS and D-CEGUS studies, respectively. Conclusion Both O-CEGUS and D-CEGUS can differentiate ≤T1 gastric cancer from ≥T2 gastric cancer, thus assisting the formulation of clinical treatment strategies for patients with very early gastric cancer. Given its simplicity and cost-effectiveness, O-CEGUS is often favored as a staging method for gastric cancer prior to endoscopic intervention.https://doi.org/10.1186/s12885-024-12210-zGastric ultrasonographyContrast agentGastric cancerT-stageMeta-analysis |
| spellingShingle | Yuan Zhong Yan-Yan Xiao Jie-Yi Ye Guo-Liang Jian Wei-Jun Huang Diagnostic efficacy of contrast-enhanced gastric ultrasonography in staging gastric cancer: a meta-analysis BMC Cancer Gastric ultrasonography Contrast agent Gastric cancer T-stage Meta-analysis |
| title | Diagnostic efficacy of contrast-enhanced gastric ultrasonography in staging gastric cancer: a meta-analysis |
| title_full | Diagnostic efficacy of contrast-enhanced gastric ultrasonography in staging gastric cancer: a meta-analysis |
| title_fullStr | Diagnostic efficacy of contrast-enhanced gastric ultrasonography in staging gastric cancer: a meta-analysis |
| title_full_unstemmed | Diagnostic efficacy of contrast-enhanced gastric ultrasonography in staging gastric cancer: a meta-analysis |
| title_short | Diagnostic efficacy of contrast-enhanced gastric ultrasonography in staging gastric cancer: a meta-analysis |
| title_sort | diagnostic efficacy of contrast enhanced gastric ultrasonography in staging gastric cancer a meta analysis |
| topic | Gastric ultrasonography Contrast agent Gastric cancer T-stage Meta-analysis |
| url | https://doi.org/10.1186/s12885-024-12210-z |
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