Antiviral properties of chalcones and their synthetic derivatives: a mini review
Chalcones (natural or synthetic derivatives) are aromatic ketones possessing a central backbone that form a core for variety important compounds with different substitutions. Recent scientific advances show that chalcones exhibit different bio-medical activities, including antiviral, which is relate...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Pensoft Publishers
2020-11-01
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| Series: | Pharmacia |
| Online Access: | https://pharmacia.pensoft.net/article/53842/download/pdf/ |
| _version_ | 1818349648649125888 |
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| author | Radoslav Marinov Nadezhda Markova Stefka Krumova Kamelia Yotovska Maya M. Zaharieva Petia Genova-Kalou |
| author_facet | Radoslav Marinov Nadezhda Markova Stefka Krumova Kamelia Yotovska Maya M. Zaharieva Petia Genova-Kalou |
| author_sort | Radoslav Marinov |
| collection | DOAJ |
| description | Chalcones (natural or synthetic derivatives) are aromatic ketones possessing a central backbone that form a core for variety important compounds with different substitutions. Recent scientific advances show that chalcones exhibit different bio-medical activities, including antiviral, which is related to the variety substitutions. This review provides general information on the origin, sources, virucidal and direct antiviral properties of chalcones in vitro, as well as a brief overview of the possible application and molecular modes of action of these compounds. The antiviral effect of chalcones probably results from the disruption of the different stage of viral replication cycle, inhibition of viral or cell enzymes, induction of apoptosis and others. Structural requirements for antiviral activities vary according to the mechanisms of action. Based on the published information, it could be considered that synthetic chalcones are very perspective antiviral candidates and deserve further studies for elucidating of their pharmacological potential. |
| first_indexed | 2024-12-13T18:09:18Z |
| format | Article |
| id | doaj.art-0a18dde5dfc243e9b11506c778ec61db |
| institution | Directory Open Access Journal |
| issn | 2603-557X |
| language | English |
| last_indexed | 2024-12-13T18:09:18Z |
| publishDate | 2020-11-01 |
| publisher | Pensoft Publishers |
| record_format | Article |
| series | Pharmacia |
| spelling | doaj.art-0a18dde5dfc243e9b11506c778ec61db2022-12-21T23:36:00ZengPensoft PublishersPharmacia2603-557X2020-11-0167432533710.3897/pharmacia.67.e5384253842Antiviral properties of chalcones and their synthetic derivatives: a mini reviewRadoslav Marinov0Nadezhda Markova1Stefka Krumova2Kamelia Yotovska3Maya M. Zaharieva4Petia Genova-Kalou5National Centre of Infectious and Parasitic DiseasesInstitute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of SciencesNational Centre of Infectious and Parasitic DiseasesSofia University St. Kliment OhridskiThe Stephan Angeloff Institute of Microbiology, Bulgarian Academy of SciencesNational Centre of Infectious and Parasitic DiseasesChalcones (natural or synthetic derivatives) are aromatic ketones possessing a central backbone that form a core for variety important compounds with different substitutions. Recent scientific advances show that chalcones exhibit different bio-medical activities, including antiviral, which is related to the variety substitutions. This review provides general information on the origin, sources, virucidal and direct antiviral properties of chalcones in vitro, as well as a brief overview of the possible application and molecular modes of action of these compounds. The antiviral effect of chalcones probably results from the disruption of the different stage of viral replication cycle, inhibition of viral or cell enzymes, induction of apoptosis and others. Structural requirements for antiviral activities vary according to the mechanisms of action. Based on the published information, it could be considered that synthetic chalcones are very perspective antiviral candidates and deserve further studies for elucidating of their pharmacological potential.https://pharmacia.pensoft.net/article/53842/download/pdf/ |
| spellingShingle | Radoslav Marinov Nadezhda Markova Stefka Krumova Kamelia Yotovska Maya M. Zaharieva Petia Genova-Kalou Antiviral properties of chalcones and their synthetic derivatives: a mini review Pharmacia |
| title | Antiviral properties of chalcones and their synthetic derivatives: a mini review |
| title_full | Antiviral properties of chalcones and their synthetic derivatives: a mini review |
| title_fullStr | Antiviral properties of chalcones and their synthetic derivatives: a mini review |
| title_full_unstemmed | Antiviral properties of chalcones and their synthetic derivatives: a mini review |
| title_short | Antiviral properties of chalcones and their synthetic derivatives: a mini review |
| title_sort | antiviral properties of chalcones and their synthetic derivatives a mini review |
| url | https://pharmacia.pensoft.net/article/53842/download/pdf/ |
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