Microbial Culture Characteristics and Antimicrobial Susceptibility Patterns Associated with Vesicovaginal Fistula
Vesicovaginal fistula (VVF) is commonly linked with recurrent urinary tract infection (UTI). Thus, the patterns of the pathogenic microorganism becomes important consideration in the management of this disease. This study aimed to describe patient profiles, disease etiology, and antimicrobial suscep...
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| Format: | Article |
| Language: | English |
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Universitas Padjajaran
2022-06-01
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| Series: | Majalah Kedokteran Bandung |
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| Online Access: | http://journal.fk.unpad.ac.id/index.php/mkb/article/view/2511 |
| _version_ | 1818113276480847872 |
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| author | Gugum Indra Firdaus Tjahjodjati Tjahjodjati |
| author_facet | Gugum Indra Firdaus Tjahjodjati Tjahjodjati |
| author_sort | Gugum Indra Firdaus |
| collection | DOAJ |
| description | Vesicovaginal fistula (VVF) is commonly linked with recurrent urinary tract infection (UTI). Thus, the patterns of the pathogenic microorganism becomes important consideration in the management of this disease. This study aimed to describe patient profiles, disease etiology, and antimicrobial susceptibility patterns of microorganisms in VVF patients. This retrospective study was conducted on 49 medical records of vesicovaginal fistula patients seen from January 2016 to December 2020. The most prevalent age group of the patients was 40-50 years old. Analysis demonstrated that the leading etiology for VVF among these patients was malignancy (73.47%). The antimicrobial susceptibility was tested using the disc diffusion method and Escherichia coli (44.90%) and Proteus mirabilis (14.29%) were identified as the bacterial pathogens most frequently isolated from urine samples. Of the 39 patients with significant growth of organism cases, 29 (74.35%) had symptomatic UTIs. The isolated gram-negative bacteria had excellent sensitivity to aztreonam, ertapenem, and meropenem, with a more than 90% susceptibility rate, while the gram-positive bacteria had good sensitivity to amikacin, cefepime, tigecycline, aztreonam, ertapenem, and meropenem, with a more than 90% susceptibility. In conclusion, bacterial culture and antibiotic susceptibility test (AST) remains an essential part of managing VVF and their results can be used as a reference for empirical therapy. Amikacin, cefepime, tigecycline, aztreonam, ertapenem, and meropenem should be considered for treatment of UTIs associated with VVF. |
| first_indexed | 2024-12-11T03:32:16Z |
| format | Article |
| id | doaj.art-0a1b752eddf84f2db6a503dd7f8512b4 |
| institution | Directory Open Access Journal |
| issn | 0126-074X 2338-6223 |
| language | English |
| last_indexed | 2024-12-11T03:32:16Z |
| publishDate | 2022-06-01 |
| publisher | Universitas Padjajaran |
| record_format | Article |
| series | Majalah Kedokteran Bandung |
| spelling | doaj.art-0a1b752eddf84f2db6a503dd7f8512b42022-12-22T01:22:20ZengUniversitas PadjajaranMajalah Kedokteran Bandung0126-074X2338-62232022-06-0154210.15395/mkb.v54n2.25111434Microbial Culture Characteristics and Antimicrobial Susceptibility Patterns Associated with Vesicovaginal FistulaGugum Indra Firdaus0Tjahjodjati Tjahjodjati1Department of Urology Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, BandungDepartment of Urology Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, BandungVesicovaginal fistula (VVF) is commonly linked with recurrent urinary tract infection (UTI). Thus, the patterns of the pathogenic microorganism becomes important consideration in the management of this disease. This study aimed to describe patient profiles, disease etiology, and antimicrobial susceptibility patterns of microorganisms in VVF patients. This retrospective study was conducted on 49 medical records of vesicovaginal fistula patients seen from January 2016 to December 2020. The most prevalent age group of the patients was 40-50 years old. Analysis demonstrated that the leading etiology for VVF among these patients was malignancy (73.47%). The antimicrobial susceptibility was tested using the disc diffusion method and Escherichia coli (44.90%) and Proteus mirabilis (14.29%) were identified as the bacterial pathogens most frequently isolated from urine samples. Of the 39 patients with significant growth of organism cases, 29 (74.35%) had symptomatic UTIs. The isolated gram-negative bacteria had excellent sensitivity to aztreonam, ertapenem, and meropenem, with a more than 90% susceptibility rate, while the gram-positive bacteria had good sensitivity to amikacin, cefepime, tigecycline, aztreonam, ertapenem, and meropenem, with a more than 90% susceptibility. In conclusion, bacterial culture and antibiotic susceptibility test (AST) remains an essential part of managing VVF and their results can be used as a reference for empirical therapy. Amikacin, cefepime, tigecycline, aztreonam, ertapenem, and meropenem should be considered for treatment of UTIs associated with VVF.http://journal.fk.unpad.ac.id/index.php/mkb/article/view/2511antimicrobialculturesensitivityvesicovaginal fistula |
| spellingShingle | Gugum Indra Firdaus Tjahjodjati Tjahjodjati Microbial Culture Characteristics and Antimicrobial Susceptibility Patterns Associated with Vesicovaginal Fistula Majalah Kedokteran Bandung antimicrobial culture sensitivity vesicovaginal fistula |
| title | Microbial Culture Characteristics and Antimicrobial Susceptibility Patterns Associated with Vesicovaginal Fistula |
| title_full | Microbial Culture Characteristics and Antimicrobial Susceptibility Patterns Associated with Vesicovaginal Fistula |
| title_fullStr | Microbial Culture Characteristics and Antimicrobial Susceptibility Patterns Associated with Vesicovaginal Fistula |
| title_full_unstemmed | Microbial Culture Characteristics and Antimicrobial Susceptibility Patterns Associated with Vesicovaginal Fistula |
| title_short | Microbial Culture Characteristics and Antimicrobial Susceptibility Patterns Associated with Vesicovaginal Fistula |
| title_sort | microbial culture characteristics and antimicrobial susceptibility patterns associated with vesicovaginal fistula |
| topic | antimicrobial culture sensitivity vesicovaginal fistula |
| url | http://journal.fk.unpad.ac.id/index.php/mkb/article/view/2511 |
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