Bioprospecting Phenols as Inhibitors of Trichothecene-Producing <i>Fusarium</i>: Sustainable Approaches to the Management of Wheat Pathogens
<i>Fusarium</i> spp. are ubiquitous fungi able to cause Fusarium head blight and Fusarium foot and root rot on wheat. Among relevant pathogenic species, <i>Fusarium graminearum</i> and <i>Fusarium culmorum</i> cause significant yield and quality loss and result in...
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MDPI AG
2022-01-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/14/2/72 |
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| author | Wiem Chtioui Virgilio Balmas Giovanna Delogu Quirico Migheli Safa Oufensou |
| author_facet | Wiem Chtioui Virgilio Balmas Giovanna Delogu Quirico Migheli Safa Oufensou |
| author_sort | Wiem Chtioui |
| collection | DOAJ |
| description | <i>Fusarium</i> spp. are ubiquitous fungi able to cause Fusarium head blight and Fusarium foot and root rot on wheat. Among relevant pathogenic species, <i>Fusarium graminearum</i> and <i>Fusarium culmorum</i> cause significant yield and quality loss and result in contamination of the grain with mycotoxins, mainly type B trichothecenes, which are a major health concern for humans and animals. Phenolic compounds of natural origin are being increasingly explored as fungicides on those pathogens. This review summarizes recent research activities related to the antifungal and anti-mycotoxigenic activity of natural phenolic compounds against <i>Fusarium</i>, including studies into the mechanisms of action of major exogenous phenolic inhibitors, their structure-activity interaction, and the combined effect of these compounds with other natural products or with conventional fungicides in mycotoxin modulation. The role of high-throughput analysis tools to decipher key signaling molecules able to modulate the production of mycotoxins and the development of sustainable formulations enhancing potential inhibitors’ efficacy are also discussed. |
| first_indexed | 2024-03-09T20:56:05Z |
| format | Article |
| id | doaj.art-0a1c5e516cd94dd4bbee6706f3445068 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-09T20:56:05Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-0a1c5e516cd94dd4bbee6706f34450682023-11-23T22:20:56ZengMDPI AGToxins2072-66512022-01-011427210.3390/toxins14020072Bioprospecting Phenols as Inhibitors of Trichothecene-Producing <i>Fusarium</i>: Sustainable Approaches to the Management of Wheat PathogensWiem Chtioui0Virgilio Balmas1Giovanna Delogu2Quirico Migheli3Safa Oufensou4Dipartimento di Agraria, Università degli Studi di Sassari, Via E. De Nicola 9, 07100 Sassari, ItalyDipartimento di Agraria, Università degli Studi di Sassari, Via E. De Nicola 9, 07100 Sassari, ItalyIstituto CNR di Chimica Biomolecolare, Traversa La Crucca 3, 07100 Sassari, ItalyDipartimento di Agraria, Università degli Studi di Sassari, Via E. De Nicola 9, 07100 Sassari, ItalyDipartimento di Agraria, Università degli Studi di Sassari, Via E. De Nicola 9, 07100 Sassari, Italy<i>Fusarium</i> spp. are ubiquitous fungi able to cause Fusarium head blight and Fusarium foot and root rot on wheat. Among relevant pathogenic species, <i>Fusarium graminearum</i> and <i>Fusarium culmorum</i> cause significant yield and quality loss and result in contamination of the grain with mycotoxins, mainly type B trichothecenes, which are a major health concern for humans and animals. Phenolic compounds of natural origin are being increasingly explored as fungicides on those pathogens. This review summarizes recent research activities related to the antifungal and anti-mycotoxigenic activity of natural phenolic compounds against <i>Fusarium</i>, including studies into the mechanisms of action of major exogenous phenolic inhibitors, their structure-activity interaction, and the combined effect of these compounds with other natural products or with conventional fungicides in mycotoxin modulation. The role of high-throughput analysis tools to decipher key signaling molecules able to modulate the production of mycotoxins and the development of sustainable formulations enhancing potential inhibitors’ efficacy are also discussed.https://www.mdpi.com/2072-6651/14/2/72phenolics<i>Fusarium</i>wheatFusarium head blighttrichothecene mycotoxinscereals |
| spellingShingle | Wiem Chtioui Virgilio Balmas Giovanna Delogu Quirico Migheli Safa Oufensou Bioprospecting Phenols as Inhibitors of Trichothecene-Producing <i>Fusarium</i>: Sustainable Approaches to the Management of Wheat Pathogens Toxins phenolics <i>Fusarium</i> wheat Fusarium head blight trichothecene mycotoxins cereals |
| title | Bioprospecting Phenols as Inhibitors of Trichothecene-Producing <i>Fusarium</i>: Sustainable Approaches to the Management of Wheat Pathogens |
| title_full | Bioprospecting Phenols as Inhibitors of Trichothecene-Producing <i>Fusarium</i>: Sustainable Approaches to the Management of Wheat Pathogens |
| title_fullStr | Bioprospecting Phenols as Inhibitors of Trichothecene-Producing <i>Fusarium</i>: Sustainable Approaches to the Management of Wheat Pathogens |
| title_full_unstemmed | Bioprospecting Phenols as Inhibitors of Trichothecene-Producing <i>Fusarium</i>: Sustainable Approaches to the Management of Wheat Pathogens |
| title_short | Bioprospecting Phenols as Inhibitors of Trichothecene-Producing <i>Fusarium</i>: Sustainable Approaches to the Management of Wheat Pathogens |
| title_sort | bioprospecting phenols as inhibitors of trichothecene producing i fusarium i sustainable approaches to the management of wheat pathogens |
| topic | phenolics <i>Fusarium</i> wheat Fusarium head blight trichothecene mycotoxins cereals |
| url | https://www.mdpi.com/2072-6651/14/2/72 |
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