Antithrombin III treatment for portal vein thrombosis after living donor liver transplantation: a case report
Abstract Background There have been no reports on the effectiveness of the administration of antithrombin III (AT III) for post-transplant portal vein thrombosis (PVT). We herein report a case of post-transplant PVT that was resolved by AT III treatment after living donor liver transplantation (LDLT...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-07-01
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| Series: | Surgical Case Reports |
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| Online Access: | http://link.springer.com/article/10.1186/s40792-020-00920-y |
| _version_ | 1818994105607258112 |
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| author | Yuta Hirata Yukihiro Sanada Takahiko Omameuda Takumi Katano Go Miyahara Naoya Yamada Noriki Okada Yasuharu Onishi Yasunaru Sakuma Naohiro Sata |
| author_facet | Yuta Hirata Yukihiro Sanada Takahiko Omameuda Takumi Katano Go Miyahara Naoya Yamada Noriki Okada Yasuharu Onishi Yasunaru Sakuma Naohiro Sata |
| author_sort | Yuta Hirata |
| collection | DOAJ |
| description | Abstract Background There have been no reports on the effectiveness of the administration of antithrombin III (AT III) for post-transplant portal vein thrombosis (PVT). We herein report a case of post-transplant PVT that was resolved by AT III treatment after living donor liver transplantation (LDLT). Case presentation The patient was a 57-year-old man who had been diagnosed with decompensate liver cirrhosis by hepatitis C virus infection. He presented with repeated hepatic coma and refractory ascites. Computed tomography (CT) revealed PVT of Yerdel classification grade II before LDLT. He underwent ABO-identical LDLT using a right lobe graft. A liver function test revealed elevated liver enzyme levels on post-operative day (POD) 14. The CT examination on POD 15 revealed PVT in the left side of the main portal vein at the side of left gastric vein ligation. AT III treatment from POD 15 to POD 24 was performed. Magnetic resonance imaging revealed that the PVT had decreased 10% on POD 27. Furthermore, AT III treatment from POD 28 to POD 32 was performed. The CT examination demonstrated the disappearance of PVT on POD 69 and thereafter, he had no recurrence of PVT on 10 post-operative month (POM). Conclusions The present case suggests that the administration of AT III is safe and suitable for the treatment of post-transplant PVT. |
| first_indexed | 2024-12-20T20:52:40Z |
| format | Article |
| id | doaj.art-0a1c9e8315e243c9b4cd74f2fca1c821 |
| institution | Directory Open Access Journal |
| issn | 2198-7793 |
| language | English |
| last_indexed | 2024-12-20T20:52:40Z |
| publishDate | 2020-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj.art-0a1c9e8315e243c9b4cd74f2fca1c8212022-12-21T19:26:54ZengSpringerOpenSurgical Case Reports2198-77932020-07-01611410.1186/s40792-020-00920-yAntithrombin III treatment for portal vein thrombosis after living donor liver transplantation: a case reportYuta Hirata0Yukihiro Sanada1Takahiko Omameuda2Takumi Katano3Go Miyahara4Naoya Yamada5Noriki Okada6Yasuharu Onishi7Yasunaru Sakuma8Naohiro Sata9Department of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical UniversityDepartment of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical UniversityDepartment of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical UniversityDepartment of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical UniversityDepartment of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical UniversityDepartment of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical UniversityDepartment of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical UniversityDepartment of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical UniversityDepartment of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical UniversityDepartment of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical UniversityAbstract Background There have been no reports on the effectiveness of the administration of antithrombin III (AT III) for post-transplant portal vein thrombosis (PVT). We herein report a case of post-transplant PVT that was resolved by AT III treatment after living donor liver transplantation (LDLT). Case presentation The patient was a 57-year-old man who had been diagnosed with decompensate liver cirrhosis by hepatitis C virus infection. He presented with repeated hepatic coma and refractory ascites. Computed tomography (CT) revealed PVT of Yerdel classification grade II before LDLT. He underwent ABO-identical LDLT using a right lobe graft. A liver function test revealed elevated liver enzyme levels on post-operative day (POD) 14. The CT examination on POD 15 revealed PVT in the left side of the main portal vein at the side of left gastric vein ligation. AT III treatment from POD 15 to POD 24 was performed. Magnetic resonance imaging revealed that the PVT had decreased 10% on POD 27. Furthermore, AT III treatment from POD 28 to POD 32 was performed. The CT examination demonstrated the disappearance of PVT on POD 69 and thereafter, he had no recurrence of PVT on 10 post-operative month (POM). Conclusions The present case suggests that the administration of AT III is safe and suitable for the treatment of post-transplant PVT.http://link.springer.com/article/10.1186/s40792-020-00920-yAntithrombin IIIPortal vein thrombosisLiving donor liver transplantationLiver transplantation |
| spellingShingle | Yuta Hirata Yukihiro Sanada Takahiko Omameuda Takumi Katano Go Miyahara Naoya Yamada Noriki Okada Yasuharu Onishi Yasunaru Sakuma Naohiro Sata Antithrombin III treatment for portal vein thrombosis after living donor liver transplantation: a case report Surgical Case Reports Antithrombin III Portal vein thrombosis Living donor liver transplantation Liver transplantation |
| title | Antithrombin III treatment for portal vein thrombosis after living donor liver transplantation: a case report |
| title_full | Antithrombin III treatment for portal vein thrombosis after living donor liver transplantation: a case report |
| title_fullStr | Antithrombin III treatment for portal vein thrombosis after living donor liver transplantation: a case report |
| title_full_unstemmed | Antithrombin III treatment for portal vein thrombosis after living donor liver transplantation: a case report |
| title_short | Antithrombin III treatment for portal vein thrombosis after living donor liver transplantation: a case report |
| title_sort | antithrombin iii treatment for portal vein thrombosis after living donor liver transplantation a case report |
| topic | Antithrombin III Portal vein thrombosis Living donor liver transplantation Liver transplantation |
| url | http://link.springer.com/article/10.1186/s40792-020-00920-y |
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