Lower waist circumference in mildly-stunted adolescents is associated with elevated insulin concentration
Objective: Augmented waist circumference (WC) is associated with non-communicable diseases and could represent a valuable marker in screening for metabolic dysfunctions in subjects with insufficient linear growth. The objective of the present study was to determine whether bio-chemical and hemodynam...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2014-09-01
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| Series: | Jornal de Pediatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572014000500479&lng=en&tlng=en |
| _version_ | 1819294970281984000 |
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| author | Ana Paula Grotti Clemente Carla Danusa da Luz Santos Vinicius J.B. Martins Maria Paula Albuquerque Mariana B. Fachim Ana Lydia Sawaya |
| author_facet | Ana Paula Grotti Clemente Carla Danusa da Luz Santos Vinicius J.B. Martins Maria Paula Albuquerque Mariana B. Fachim Ana Lydia Sawaya |
| author_sort | Ana Paula Grotti Clemente |
| collection | DOAJ |
| description | Objective: Augmented waist circumference (WC) is associated with non-communicable diseases and could represent a valuable marker in screening for metabolic dysfunctions in subjects with insufficient linear growth. The objective of the present study was to determine whether bio-chemical and hemodynamic parameters and waist circumference vary between mildly-stunted and non-stunted adolescents from impoverished communities of São Paulo, Brazil. Methods: The cross-sectional study involved 206 subjects, aged between 9 and 19 years and living in impoverished areas of São Paulo, Brazil. The sample population was divided according to height-for-age Z-score (HAZ) into stunted (−1 > HAZ ≥ −2) and non-stunted (HAZ ≥ −1) groups, and was sub-divided according to gender. Logistic regression analysis was employed to compare individuals with elevated (> 75th percentile) insulin concentrations. The receiver operating characteristic curves were constructed to determine WC cut-off points that could be used to identify stunted and non-stunted individuals with elevated insulin concentrations. Results: WC cut-off points of 58.25 cm and 67.2 cm allowed for correct classification of 90.7% of stunted and 88.7% of non-stunted individuals in the studied population. While the sensitivity of the model was high for stunted and non-stunted subjects (98.8% and 97.2%, respectively), the specificity was modest (57.1% and 41.2%, respectively). Conclusion: The results presented herein suggest that an increase in plasma insulin is one of the primary metabolic modifications in stunted individuals, and that this alteration could be identified at a lower WC cut-off point than in non-stunted counterparts. |
| first_indexed | 2024-12-24T04:34:47Z |
| format | Article |
| id | doaj.art-0a1fa0d375d24e3880d1bcb76f8ed95d |
| institution | Directory Open Access Journal |
| issn | 1678-4782 |
| language | English |
| last_indexed | 2024-12-24T04:34:47Z |
| publishDate | 2014-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Jornal de Pediatria |
| spelling | doaj.art-0a1fa0d375d24e3880d1bcb76f8ed95d2022-12-21T17:15:15ZengElsevierJornal de Pediatria1678-47822014-09-0190547948510.1016/j.jped.2014.01.015S0021-75572014000500479Lower waist circumference in mildly-stunted adolescents is associated with elevated insulin concentrationAna Paula Grotti ClementeCarla Danusa da Luz SantosVinicius J.B. MartinsMaria Paula AlbuquerqueMariana B. FachimAna Lydia SawayaObjective: Augmented waist circumference (WC) is associated with non-communicable diseases and could represent a valuable marker in screening for metabolic dysfunctions in subjects with insufficient linear growth. The objective of the present study was to determine whether bio-chemical and hemodynamic parameters and waist circumference vary between mildly-stunted and non-stunted adolescents from impoverished communities of São Paulo, Brazil. Methods: The cross-sectional study involved 206 subjects, aged between 9 and 19 years and living in impoverished areas of São Paulo, Brazil. The sample population was divided according to height-for-age Z-score (HAZ) into stunted (−1 > HAZ ≥ −2) and non-stunted (HAZ ≥ −1) groups, and was sub-divided according to gender. Logistic regression analysis was employed to compare individuals with elevated (> 75th percentile) insulin concentrations. The receiver operating characteristic curves were constructed to determine WC cut-off points that could be used to identify stunted and non-stunted individuals with elevated insulin concentrations. Results: WC cut-off points of 58.25 cm and 67.2 cm allowed for correct classification of 90.7% of stunted and 88.7% of non-stunted individuals in the studied population. While the sensitivity of the model was high for stunted and non-stunted subjects (98.8% and 97.2%, respectively), the specificity was modest (57.1% and 41.2%, respectively). Conclusion: The results presented herein suggest that an increase in plasma insulin is one of the primary metabolic modifications in stunted individuals, and that this alteration could be identified at a lower WC cut-off point than in non-stunted counterparts.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572014000500479&lng=en&tlng=enCircunferência da cinturaAlturaInsulina |
| spellingShingle | Ana Paula Grotti Clemente Carla Danusa da Luz Santos Vinicius J.B. Martins Maria Paula Albuquerque Mariana B. Fachim Ana Lydia Sawaya Lower waist circumference in mildly-stunted adolescents is associated with elevated insulin concentration Jornal de Pediatria Circunferência da cintura Altura Insulina |
| title | Lower waist circumference in mildly-stunted adolescents is associated with elevated insulin concentration |
| title_full | Lower waist circumference in mildly-stunted adolescents is associated with elevated insulin concentration |
| title_fullStr | Lower waist circumference in mildly-stunted adolescents is associated with elevated insulin concentration |
| title_full_unstemmed | Lower waist circumference in mildly-stunted adolescents is associated with elevated insulin concentration |
| title_short | Lower waist circumference in mildly-stunted adolescents is associated with elevated insulin concentration |
| title_sort | lower waist circumference in mildly stunted adolescents is associated with elevated insulin concentration |
| topic | Circunferência da cintura Altura Insulina |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572014000500479&lng=en&tlng=en |
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