Air pollution after acute bronchiolitis is a risk factor for preschool asthma: a nested case-control study
Abstract Background Acute bronchiolitis and air pollution are both risk factor of pediatric asthma. This study aimed to assess subsequent exposure to air pollutants related to the inception of preschool asthma in infants with acute bronchiolitis. This study aimed to assess subsequent exposure to air...
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | Environmental Health |
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| Online Access: | https://doi.org/10.1186/s12940-023-01035-1 |
| _version_ | 1827590322499092480 |
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| author | Hao-Wei Chung Hui-Min Hsieh Chung-Hsiang Lee Yi-Ching Lin Yu-Hsiang Tsao Ming-Chu Feng Chih-Hsing Hung |
| author_facet | Hao-Wei Chung Hui-Min Hsieh Chung-Hsiang Lee Yi-Ching Lin Yu-Hsiang Tsao Ming-Chu Feng Chih-Hsing Hung |
| author_sort | Hao-Wei Chung |
| collection | DOAJ |
| description | Abstract Background Acute bronchiolitis and air pollution are both risk factor of pediatric asthma. This study aimed to assess subsequent exposure to air pollutants related to the inception of preschool asthma in infants with acute bronchiolitis. This study aimed to assess subsequent exposure to air pollutants related to the inception of preschool asthma in infants with acute bronchiolitis. Methods A nested case-control retrospective study was performed at the Kaohsiung Medical University Hospital systems between 2009 and 2019. The average concentration of PM10, PM2.5, SO2, NO, NO2, and NOX was collected for three, six, and twelve months after the first infected episode. Adjusted regression models were employed to evaluate the association between asthma and air pollution exposure after bronchiolitis. Results Two thousand six hundred thirty-seven children with acute bronchiolitis were included. Exposure to PM10, PM2.5, SO2, NO, NO2, and NOX in the three, six, and twelve months following an episode of bronchiolitis was found to significantly increase the risk of preschool asthma in infants with a history of bronchiolitis.(OR, 95%CI: PM10 = 1.517-1.559, 1.354–1.744; PM2.5 = 2.510-2.603, 2.148–3.061; SO2 = 1.970-2.040, 1.724–2.342; ; NO = 1.915-1.950, 1.647–2.272; NO2 = 1.915-1.950, 1.647–2.272; NOX = 1.752-1.970, 1.508–2.252) In a sensitive analysis of hospitalized infants, only PM10, PM2.5, SO2, and NO were found to have significant effects during all time periods. (OR, 95%CI: PM10 = 1.613-1.650, 1.240–2.140; PM2.5 = 2.208-2.286, 1.568–3.061; SO2 = 1.679-1.622, 1.197–2.292; NO = 1.525-1.557, 1.094–2.181) Conclusion The presence of ambient PM10, PM2.5, SO2 and NO in the three, six, and twelve months following an episode of acute bronchiolitis has been linked to the development of preschool asthma in infants with a history of acute bronchiolitis. |
| first_indexed | 2024-03-09T01:15:16Z |
| format | Article |
| id | doaj.art-0a2105b00e5e45bcb0a66af4f206a2d9 |
| institution | Directory Open Access Journal |
| issn | 1476-069X |
| language | English |
| last_indexed | 2024-03-09T01:15:16Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Environmental Health |
| spelling | doaj.art-0a2105b00e5e45bcb0a66af4f206a2d92023-12-10T12:30:15ZengBMCEnvironmental Health1476-069X2023-12-012211910.1186/s12940-023-01035-1Air pollution after acute bronchiolitis is a risk factor for preschool asthma: a nested case-control studyHao-Wei Chung0Hui-Min Hsieh1Chung-Hsiang Lee2Yi-Ching Lin3Yu-Hsiang Tsao4Ming-Chu Feng5Chih-Hsing Hung6Department of Pediatrics, Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung Medical UniversityDepartment of Public Health, Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung Medical UniversityDepartment of Pediatrics, Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung Medical UniversityDepartment of Medical Research, Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung Medical UniversityDepartment of Medical Research, Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung Medical UniversityDepartment of Dysphagia Functional Reconstructive Center, Kaohsiung Municipal Siaogang HospitalDepartment of Pediatrics, Kaohsiung Municipal Siaogang HospitalAbstract Background Acute bronchiolitis and air pollution are both risk factor of pediatric asthma. This study aimed to assess subsequent exposure to air pollutants related to the inception of preschool asthma in infants with acute bronchiolitis. This study aimed to assess subsequent exposure to air pollutants related to the inception of preschool asthma in infants with acute bronchiolitis. Methods A nested case-control retrospective study was performed at the Kaohsiung Medical University Hospital systems between 2009 and 2019. The average concentration of PM10, PM2.5, SO2, NO, NO2, and NOX was collected for three, six, and twelve months after the first infected episode. Adjusted regression models were employed to evaluate the association between asthma and air pollution exposure after bronchiolitis. Results Two thousand six hundred thirty-seven children with acute bronchiolitis were included. Exposure to PM10, PM2.5, SO2, NO, NO2, and NOX in the three, six, and twelve months following an episode of bronchiolitis was found to significantly increase the risk of preschool asthma in infants with a history of bronchiolitis.(OR, 95%CI: PM10 = 1.517-1.559, 1.354–1.744; PM2.5 = 2.510-2.603, 2.148–3.061; SO2 = 1.970-2.040, 1.724–2.342; ; NO = 1.915-1.950, 1.647–2.272; NO2 = 1.915-1.950, 1.647–2.272; NOX = 1.752-1.970, 1.508–2.252) In a sensitive analysis of hospitalized infants, only PM10, PM2.5, SO2, and NO were found to have significant effects during all time periods. (OR, 95%CI: PM10 = 1.613-1.650, 1.240–2.140; PM2.5 = 2.208-2.286, 1.568–3.061; SO2 = 1.679-1.622, 1.197–2.292; NO = 1.525-1.557, 1.094–2.181) Conclusion The presence of ambient PM10, PM2.5, SO2 and NO in the three, six, and twelve months following an episode of acute bronchiolitis has been linked to the development of preschool asthma in infants with a history of acute bronchiolitis.https://doi.org/10.1186/s12940-023-01035-1Ambient air pollutionPreschool asthmaAcute bronchiolitis infant |
| spellingShingle | Hao-Wei Chung Hui-Min Hsieh Chung-Hsiang Lee Yi-Ching Lin Yu-Hsiang Tsao Ming-Chu Feng Chih-Hsing Hung Air pollution after acute bronchiolitis is a risk factor for preschool asthma: a nested case-control study Environmental Health Ambient air pollution Preschool asthma Acute bronchiolitis infant |
| title | Air pollution after acute bronchiolitis is a risk factor for preschool asthma: a nested case-control study |
| title_full | Air pollution after acute bronchiolitis is a risk factor for preschool asthma: a nested case-control study |
| title_fullStr | Air pollution after acute bronchiolitis is a risk factor for preschool asthma: a nested case-control study |
| title_full_unstemmed | Air pollution after acute bronchiolitis is a risk factor for preschool asthma: a nested case-control study |
| title_short | Air pollution after acute bronchiolitis is a risk factor for preschool asthma: a nested case-control study |
| title_sort | air pollution after acute bronchiolitis is a risk factor for preschool asthma a nested case control study |
| topic | Ambient air pollution Preschool asthma Acute bronchiolitis infant |
| url | https://doi.org/10.1186/s12940-023-01035-1 |
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