The Oxidative Stress and Nervous Distress Connection in Gastrointestinal Disorders
Oxidative stress is increasingly recognized as a central player in a range of gastrointestinal (GI) disorders, as well as complications stemming from therapeutic interventions. This article presents an overview of the mechanisms of oxidative stress in GI conditions and highlights a link between oxid...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/11/1586 |
| _version_ | 1797459952141336576 |
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| author | Rhian Stavely Leah C. Ott Niloufar Rashidi Samy Sakkal Kulmira Nurgali |
| author_facet | Rhian Stavely Leah C. Ott Niloufar Rashidi Samy Sakkal Kulmira Nurgali |
| author_sort | Rhian Stavely |
| collection | DOAJ |
| description | Oxidative stress is increasingly recognized as a central player in a range of gastrointestinal (GI) disorders, as well as complications stemming from therapeutic interventions. This article presents an overview of the mechanisms of oxidative stress in GI conditions and highlights a link between oxidative insult and disruption to the enteric nervous system (ENS), which controls GI functions. The dysfunction of the ENS is characteristic of a spectrum of disorders, including neurointestinal diseases and conditions such as inflammatory bowel disease (IBD), diabetic gastroparesis, and chemotherapy-induced GI side effects. Neurons in the ENS, while essential for normal gut function, appear particularly vulnerable to oxidative damage. Mechanistically, oxidative stress in enteric neurons can result from intrinsic nitrosative injury, mitochondrial dysfunction, or inflammation-related pathways. Although antioxidant-based therapies have shown limited efficacy, recognizing the multifaceted role of oxidative stress in GI diseases offers a promising avenue for future interventions. This comprehensive review summarizes the literature to date implicating oxidative stress as a critical player in the pathophysiology of GI disorders, with a focus on its role in ENS injury and dysfunction, and highlights opportunities for the development of targeted therapeutics for these diseases. |
| first_indexed | 2024-03-09T16:59:13Z |
| format | Article |
| id | doaj.art-0a2307c5bc53443e86b16efc61c4ce6e |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T16:59:13Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-0a2307c5bc53443e86b16efc61c4ce6e2023-11-24T14:31:51ZengMDPI AGBiomolecules2218-273X2023-10-011311158610.3390/biom13111586The Oxidative Stress and Nervous Distress Connection in Gastrointestinal DisordersRhian Stavely0Leah C. Ott1Niloufar Rashidi2Samy Sakkal3Kulmira Nurgali4Department of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USADepartment of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USAInstitute for Health and Sport, Victoria University, St Albans, VIC 3021, AustraliaInstitute for Health and Sport, Victoria University, St Albans, VIC 3021, AustraliaInstitute for Health and Sport, Victoria University, St Albans, VIC 3021, AustraliaOxidative stress is increasingly recognized as a central player in a range of gastrointestinal (GI) disorders, as well as complications stemming from therapeutic interventions. This article presents an overview of the mechanisms of oxidative stress in GI conditions and highlights a link between oxidative insult and disruption to the enteric nervous system (ENS), which controls GI functions. The dysfunction of the ENS is characteristic of a spectrum of disorders, including neurointestinal diseases and conditions such as inflammatory bowel disease (IBD), diabetic gastroparesis, and chemotherapy-induced GI side effects. Neurons in the ENS, while essential for normal gut function, appear particularly vulnerable to oxidative damage. Mechanistically, oxidative stress in enteric neurons can result from intrinsic nitrosative injury, mitochondrial dysfunction, or inflammation-related pathways. Although antioxidant-based therapies have shown limited efficacy, recognizing the multifaceted role of oxidative stress in GI diseases offers a promising avenue for future interventions. This comprehensive review summarizes the literature to date implicating oxidative stress as a critical player in the pathophysiology of GI disorders, with a focus on its role in ENS injury and dysfunction, and highlights opportunities for the development of targeted therapeutics for these diseases.https://www.mdpi.com/2218-273X/13/11/1586oxidative stressreactive oxygen speciesgastrointestinalenteric nervous systementeric neuronneurointestinal |
| spellingShingle | Rhian Stavely Leah C. Ott Niloufar Rashidi Samy Sakkal Kulmira Nurgali The Oxidative Stress and Nervous Distress Connection in Gastrointestinal Disorders Biomolecules oxidative stress reactive oxygen species gastrointestinal enteric nervous system enteric neuron neurointestinal |
| title | The Oxidative Stress and Nervous Distress Connection in Gastrointestinal Disorders |
| title_full | The Oxidative Stress and Nervous Distress Connection in Gastrointestinal Disorders |
| title_fullStr | The Oxidative Stress and Nervous Distress Connection in Gastrointestinal Disorders |
| title_full_unstemmed | The Oxidative Stress and Nervous Distress Connection in Gastrointestinal Disorders |
| title_short | The Oxidative Stress and Nervous Distress Connection in Gastrointestinal Disorders |
| title_sort | oxidative stress and nervous distress connection in gastrointestinal disorders |
| topic | oxidative stress reactive oxygen species gastrointestinal enteric nervous system enteric neuron neurointestinal |
| url | https://www.mdpi.com/2218-273X/13/11/1586 |
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