Neural response to trauma‐related and trauma‐unrelated negative stimuli in remitted and persistent pediatric post‐traumatic stress disorder
Abstract Introduction Most youths who suffer from post‐traumatic stress disorder (PTSD) lose their diagnosis in the first 1–2 years. However, there are few studies on this brain mechanism, and the heterogeneity of the findings is partially due to the different stimuli applied and the mixed trauma hi...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-07-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.2173 |
| _version_ | 1819135698573197312 |
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| author | Peng Wang Zu‐Lai Peng Lu Liu Li An Yu‐Xin Liu Qing‐Jiu Cao Li Sun Ning Ji Yun Chen Bin‐Rang Yang Yu‐Feng Wang |
| author_facet | Peng Wang Zu‐Lai Peng Lu Liu Li An Yu‐Xin Liu Qing‐Jiu Cao Li Sun Ning Ji Yun Chen Bin‐Rang Yang Yu‐Feng Wang |
| author_sort | Peng Wang |
| collection | DOAJ |
| description | Abstract Introduction Most youths who suffer from post‐traumatic stress disorder (PTSD) lose their diagnosis in the first 1–2 years. However, there are few studies on this brain mechanism, and the heterogeneity of the findings is partially due to the different stimuli applied and the mixed trauma history. Therefore, the use of trauma‐related/unrelated stimuli to study the remittance mechanism of earthquake‐induced PTSD could advance our knowledge of PTSD and inspire future treatment. Methods Thirteen youths with PTSD, 18 remitted participants, and 18 control participants underwent functional magnetic resonance imaging (fMRI), while viewing trauma‐related pictures, trauma‐unrelated negative pictures, and scrambled pictures. Results Under trauma‐unrelated condition, the neural activity of the left hippocampus in the remitted group was between the two other groups. Under trauma‐related condition, the PTSD and the remitted group exhibited higher neural activity in the right middle occipital gyrus than controls. The remitted group showed higher neural activity in the right parahippocampal gyrus and right lingual gyrus under trauma‐related condition than trauma‐unrelated condition, while no significant difference was found in PTSD group. Conclusion PTSD status‐related group differences are mainly reflected in the left hippocampus under the trauma‐unrelated condition, while the hyperactivity in the right middle occipital gyrus under trauma‐related condition could be an endophenotype for PTSD. |
| first_indexed | 2024-12-22T10:23:13Z |
| format | Article |
| id | doaj.art-0a237bd3b5c14bfc8365a394f749cd2e |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-12-22T10:23:13Z |
| publishDate | 2021-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-0a237bd3b5c14bfc8365a394f749cd2e2022-12-21T18:29:33ZengWileyBrain and Behavior2162-32792021-07-01117n/an/a10.1002/brb3.2173Neural response to trauma‐related and trauma‐unrelated negative stimuli in remitted and persistent pediatric post‐traumatic stress disorderPeng Wang0Zu‐Lai Peng1Lu Liu2Li An3Yu‐Xin Liu4Qing‐Jiu Cao5Li Sun6Ning Ji7Yun Chen8Bin‐Rang Yang9Yu‐Feng Wang10Sixth Hospital/Institute of Mental Health Peking University Beijing ChinaSixth Hospital/Institute of Mental Health Peking University Beijing ChinaSixth Hospital/Institute of Mental Health Peking University Beijing ChinaSixth Hospital/Institute of Mental Health Peking University Beijing ChinaSixth Hospital/Institute of Mental Health Peking University Beijing ChinaSixth Hospital/Institute of Mental Health Peking University Beijing ChinaSixth Hospital/Institute of Mental Health Peking University Beijing ChinaSixth Hospital/Institute of Mental Health Peking University Beijing ChinaSixth Hospital/Institute of Mental Health Peking University Beijing ChinaShenzhen Children's Hospital Shenzhen ChinaSixth Hospital/Institute of Mental Health Peking University Beijing ChinaAbstract Introduction Most youths who suffer from post‐traumatic stress disorder (PTSD) lose their diagnosis in the first 1–2 years. However, there are few studies on this brain mechanism, and the heterogeneity of the findings is partially due to the different stimuli applied and the mixed trauma history. Therefore, the use of trauma‐related/unrelated stimuli to study the remittance mechanism of earthquake‐induced PTSD could advance our knowledge of PTSD and inspire future treatment. Methods Thirteen youths with PTSD, 18 remitted participants, and 18 control participants underwent functional magnetic resonance imaging (fMRI), while viewing trauma‐related pictures, trauma‐unrelated negative pictures, and scrambled pictures. Results Under trauma‐unrelated condition, the neural activity of the left hippocampus in the remitted group was between the two other groups. Under trauma‐related condition, the PTSD and the remitted group exhibited higher neural activity in the right middle occipital gyrus than controls. The remitted group showed higher neural activity in the right parahippocampal gyrus and right lingual gyrus under trauma‐related condition than trauma‐unrelated condition, while no significant difference was found in PTSD group. Conclusion PTSD status‐related group differences are mainly reflected in the left hippocampus under the trauma‐unrelated condition, while the hyperactivity in the right middle occipital gyrus under trauma‐related condition could be an endophenotype for PTSD.https://doi.org/10.1002/brb3.2173childearthquakeshippocampuspost‐traumaticremittance |
| spellingShingle | Peng Wang Zu‐Lai Peng Lu Liu Li An Yu‐Xin Liu Qing‐Jiu Cao Li Sun Ning Ji Yun Chen Bin‐Rang Yang Yu‐Feng Wang Neural response to trauma‐related and trauma‐unrelated negative stimuli in remitted and persistent pediatric post‐traumatic stress disorder Brain and Behavior child earthquakes hippocampus post‐traumatic remittance |
| title | Neural response to trauma‐related and trauma‐unrelated negative stimuli in remitted and persistent pediatric post‐traumatic stress disorder |
| title_full | Neural response to trauma‐related and trauma‐unrelated negative stimuli in remitted and persistent pediatric post‐traumatic stress disorder |
| title_fullStr | Neural response to trauma‐related and trauma‐unrelated negative stimuli in remitted and persistent pediatric post‐traumatic stress disorder |
| title_full_unstemmed | Neural response to trauma‐related and trauma‐unrelated negative stimuli in remitted and persistent pediatric post‐traumatic stress disorder |
| title_short | Neural response to trauma‐related and trauma‐unrelated negative stimuli in remitted and persistent pediatric post‐traumatic stress disorder |
| title_sort | neural response to trauma related and trauma unrelated negative stimuli in remitted and persistent pediatric post traumatic stress disorder |
| topic | child earthquakes hippocampus post‐traumatic remittance |
| url | https://doi.org/10.1002/brb3.2173 |
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