Identification of key amino acid residues modulating intracellular and in vitro microcin E492 amyloid formation

Identification of key amino acid residues modulating intracellular and in vitro microcin E492 amyloid formation

Microcin E492 (MccE492) is a pore-forming bacteriocin produced and exported by Klebsiella pneumoniae RYC492. Besides its antibacterial activity, excreted MccE492 can form amyloid fibrils in vivo as well as in vitro. It has been proposed that bacterial amyloids can be functional playing a biological...

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Bibliographic Details
Main Authors: Paulina eAguilera, Andrés eMarcoleta, Pablo eLobos-Ruiz, Rocío eArranz, José María eValpuesta, Octavio eMonasterio, Rosalba eLagos
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-01-01
Series:Frontiers in Microbiology
Subjects:
Inclusion Bodies
protein aggregation
microcin E492
intracellular amyloids
gatekeeper residues
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00035/full

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