Metabolic Hormones in Schizophrenia Patients with Antipsychotic-Induced Metabolic Syndrome
Metabolic syndrome (MetS) is a common complication of schizophrenia that is quite exacerbated by long-term use of (atypical) antipsychotics. The mechanism of MetS has neuronal, neuroendocrine, and neuroimmunological components and shows some overlap with those of aspects of schizophrenia. We examine...
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MDPI AG
2022-10-01
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| Series: | Journal of Personalized Medicine |
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| author | Anastasiia S. Boiko Irina A. Mednova Elena G. Kornetova Anastasiia A. Goncharova Arkadiy V. Semke Nikolay A. Bokhan Svetlana A. Ivanova |
| author_facet | Anastasiia S. Boiko Irina A. Mednova Elena G. Kornetova Anastasiia A. Goncharova Arkadiy V. Semke Nikolay A. Bokhan Svetlana A. Ivanova |
| author_sort | Anastasiia S. Boiko |
| collection | DOAJ |
| description | Metabolic syndrome (MetS) is a common complication of schizophrenia that is quite exacerbated by long-term use of (atypical) antipsychotics. The mechanism of MetS has neuronal, neuroendocrine, and neuroimmunological components and shows some overlap with those of aspects of schizophrenia. We examined 195 patients with schizophrenia (90 with and 105 without MetS) for the association of serum levels of ghrelin, insulin, and leptin with metabolic abnormalities. Serum glucose levels and lipid profiles were routinely measured with colorimetric enzymatic methods and hormone levels with multiplex analyzers. Leptin levels were highly significantly increased (<i>p</i> < 0.001) in people with MetS (9.966 [5.882; 21.496] vs. 6.35 [2.005; 11.753], Me [Q1; Q3]) and ghrelin levels were actually significantly decreased (<i>p</i> = 0.045). Insulin levels did not differ significantly between those with and without MetS (<i>p</i> = 0.162). In Spearman’s correlation analysis between the hormone levels, body characteristics, and biochemical parameters, significant correlations were seen somewhat more often in people without MetS than in those with MetS and also less often for ghrelin than for the other hormones. We conclude that evidence exists for a role in the development of MetS especially for leptin, but that less is supporting a role for ghrelin. |
| first_indexed | 2024-03-09T19:58:38Z |
| format | Article |
| id | doaj.art-0a261d95fd8f43df8d7662fc9ea23448 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T19:58:38Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-0a261d95fd8f43df8d7662fc9ea234482023-11-24T00:49:53ZengMDPI AGJournal of Personalized Medicine2075-44262022-10-011210165510.3390/jpm12101655Metabolic Hormones in Schizophrenia Patients with Antipsychotic-Induced Metabolic SyndromeAnastasiia S. Boiko0Irina A. Mednova1Elena G. Kornetova2Anastasiia A. Goncharova3Arkadiy V. Semke4Nikolay A. Bokhan5Svetlana A. Ivanova6Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Aleutskaya Str., 4, 634014 Tomsk, RussiaMental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Aleutskaya Str., 4, 634014 Tomsk, RussiaMental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Aleutskaya Str., 4, 634014 Tomsk, RussiaMental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Aleutskaya Str., 4, 634014 Tomsk, RussiaMental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Aleutskaya Str., 4, 634014 Tomsk, RussiaMental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Aleutskaya Str., 4, 634014 Tomsk, RussiaMental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Aleutskaya Str., 4, 634014 Tomsk, RussiaMetabolic syndrome (MetS) is a common complication of schizophrenia that is quite exacerbated by long-term use of (atypical) antipsychotics. The mechanism of MetS has neuronal, neuroendocrine, and neuroimmunological components and shows some overlap with those of aspects of schizophrenia. We examined 195 patients with schizophrenia (90 with and 105 without MetS) for the association of serum levels of ghrelin, insulin, and leptin with metabolic abnormalities. Serum glucose levels and lipid profiles were routinely measured with colorimetric enzymatic methods and hormone levels with multiplex analyzers. Leptin levels were highly significantly increased (<i>p</i> < 0.001) in people with MetS (9.966 [5.882; 21.496] vs. 6.35 [2.005; 11.753], Me [Q1; Q3]) and ghrelin levels were actually significantly decreased (<i>p</i> = 0.045). Insulin levels did not differ significantly between those with and without MetS (<i>p</i> = 0.162). In Spearman’s correlation analysis between the hormone levels, body characteristics, and biochemical parameters, significant correlations were seen somewhat more often in people without MetS than in those with MetS and also less often for ghrelin than for the other hormones. We conclude that evidence exists for a role in the development of MetS especially for leptin, but that less is supporting a role for ghrelin.https://www.mdpi.com/2075-4426/12/10/1655schizophreniametabolic syndromeantipsychoticsbody mass indexinsulinleptin |
| spellingShingle | Anastasiia S. Boiko Irina A. Mednova Elena G. Kornetova Anastasiia A. Goncharova Arkadiy V. Semke Nikolay A. Bokhan Svetlana A. Ivanova Metabolic Hormones in Schizophrenia Patients with Antipsychotic-Induced Metabolic Syndrome Journal of Personalized Medicine schizophrenia metabolic syndrome antipsychotics body mass index insulin leptin |
| title | Metabolic Hormones in Schizophrenia Patients with Antipsychotic-Induced Metabolic Syndrome |
| title_full | Metabolic Hormones in Schizophrenia Patients with Antipsychotic-Induced Metabolic Syndrome |
| title_fullStr | Metabolic Hormones in Schizophrenia Patients with Antipsychotic-Induced Metabolic Syndrome |
| title_full_unstemmed | Metabolic Hormones in Schizophrenia Patients with Antipsychotic-Induced Metabolic Syndrome |
| title_short | Metabolic Hormones in Schizophrenia Patients with Antipsychotic-Induced Metabolic Syndrome |
| title_sort | metabolic hormones in schizophrenia patients with antipsychotic induced metabolic syndrome |
| topic | schizophrenia metabolic syndrome antipsychotics body mass index insulin leptin |
| url | https://www.mdpi.com/2075-4426/12/10/1655 |
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