The spike protein of SARS-CoV-2 induces inflammation and EMT of lung epithelial cells and fibroblasts through the upregulation of GADD45A

The spike protein of SARS-CoV-2 induces inflammation and EMT of lung epithelial cells and fibroblasts through the upregulation of GADD45A

Lung epithelial cells and fibroblasts poorly express angiotensin-converting enzyme 2, and the study aimed to investigate the role of the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on inflammation and epithelial–mesenchymal transition (EMT) in two lung cell lines an...

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Bibliographic Details
Main Authors: Cai Jiehao, Ma Wenjie, Wang Xiangshi, Chang Hailing, Wei Zhongqiu, Li Jingjing, Zeng Mei
Format: Article
Language:English
Published: De Gruyter 2023-11-01
Series:Open Medicine
Subjects:
spike protein
sars-cov-2
lung cells
inflammation
emt
gadd45a
Online Access:https://doi.org/10.1515/med-2023-0779

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