CDK4/6 inhibition enhances pulmonary inflammatory infiltration in bleomycin-induced lung fibrosis

CDK4/6 inhibition enhances pulmonary inflammatory infiltration in bleomycin-induced lung fibrosis

Abstract Inhibitors of cyclin-dependent kinases 4/6 (CDK4/6) block cell cycle progression and are commonly used for treatment of several forms of cancer. Due to their anti-proliferative mode of action, we hypothesized that palbociclib could attenuate the development of bleomycin-induced lung fibrosi...

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Bibliographic Details
Main Authors: Anna Birnhuber, Bakytbek Egemnazarov, Valentina Biasin, Ehsan Bonyadi Rad, Malgorzata Wygrecka, Horst Olschewski, Grazyna Kwapiszewska, Leigh M. Marsh
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Respiratory Research
Subjects:
CDK4/6 inhibition
Palbociclib
Pulmonary inflammation
Interstitial lung disease
Online Access:http://link.springer.com/article/10.1186/s12931-020-01433-w

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