Necroptosis-driving genes RIPK1, RIPK3 and MLKL-p are associated with intratumoral CD3+ and CD8+ T cell density and predict prognosis in hepatocellular carcinoma

Necroptosis-driving genes RIPK1, RIPK3 and MLKL-p are associated with intratumoral CD3+ and CD8+ T cell density and predict prognosis in hepatocellular carcinoma

Background Hepatocellular carcinoma (HCC) is a highly lethal cancer and the second leading cause of cancer-related deaths worldwide. As demonstrated in other solid neoplasms and HCC, infiltrating CD8+ T cells seem to be related to a better prognosis, but the mechanisms affecting the immune landscape...

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Bibliographic Details
Main Authors: Akihiko Kawahara, Jun Akiba, Hirohisa Yano, Ambrogio Fassina, Rocco Cappellesso, Yoshiki Naito, Maria Guido, Paolo Simioni, Giuliana Cortese, Lorenzo Nicolè, Tiziana Sanavia, Valeria Maffeis, Claudia Maria Radu, Davide Serafin, Giacomo Zanus
Format: Article
Language:English
Published: BMJ Publishing Group 2022-03-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/10/3/e004031.full

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