Impact of HOXB7 overexpression on human adipose-derived mesenchymal progenitors
Abstract Background The ex vivo expansion potential of mesenchymal stromal/stem cells (MSC) together with their differentiation and secretion properties makes these cells an attractive tool for transplantation and tissue engineering. Although the use of MSC is currently being tested in a growing num...
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| Format: | Article |
| Language: | English |
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BMC
2019-03-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13287-019-1200-6 |
| _version_ | 1818417827411918848 |
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| author | Elisabetta Manuela Foppiani Olivia Candini Ilenia Mastrolia Alba Murgia Giulia Grisendi Anna Valeria Samarelli Giulia Boscaini Lucrezia Pacchioni Massimo Pinelli Giorgio De Santis Edwin M. Horwitz Elena Veronesi Massimo Dominici |
| author_facet | Elisabetta Manuela Foppiani Olivia Candini Ilenia Mastrolia Alba Murgia Giulia Grisendi Anna Valeria Samarelli Giulia Boscaini Lucrezia Pacchioni Massimo Pinelli Giorgio De Santis Edwin M. Horwitz Elena Veronesi Massimo Dominici |
| author_sort | Elisabetta Manuela Foppiani |
| collection | DOAJ |
| description | Abstract Background The ex vivo expansion potential of mesenchymal stromal/stem cells (MSC) together with their differentiation and secretion properties makes these cells an attractive tool for transplantation and tissue engineering. Although the use of MSC is currently being tested in a growing number of clinical trials, it is still desirable to identify molecular markers that may help improve their performance both in vitro and after transplantation. Methods Recently, HOXB7 was identified as a master player driving the proliferation and differentiation of bone marrow mesenchymal progenitors. In this study, we investigated the effect of HOXB7 overexpression on the ex vivo features of adipose mesenchymal progenitors (AD-MSC). Results HOXB7 increased AD-MSC proliferation potential, reduced senescence, and improved chondrogenesis together with a significant increase of basic fibroblast growth factor (bFGF) secretion. Conclusion While further investigations and in vivo models shall be applied for better understanding, these data suggest that modulation of HOXB7 may be a strategy for innovative tissue regeneration applications. |
| first_indexed | 2024-12-14T12:12:58Z |
| format | Article |
| id | doaj.art-0a292f3aafea4f2f8f04636163e7df0f |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-12-14T12:12:58Z |
| publishDate | 2019-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-0a292f3aafea4f2f8f04636163e7df0f2022-12-21T23:01:41ZengBMCStem Cell Research & Therapy1757-65122019-03-0110111210.1186/s13287-019-1200-6Impact of HOXB7 overexpression on human adipose-derived mesenchymal progenitorsElisabetta Manuela Foppiani0Olivia Candini1Ilenia Mastrolia2Alba Murgia3Giulia Grisendi4Anna Valeria Samarelli5Giulia Boscaini6Lucrezia Pacchioni7Massimo Pinelli8Giorgio De Santis9Edwin M. Horwitz10Elena Veronesi11Massimo Dominici12Division of Oncology, Department of Medical and Surgical Sciences for Children and Adults, University-Hospital of Modena and Reggio EmiliaDivision of Oncology, Department of Medical and Surgical Sciences for Children and Adults, University-Hospital of Modena and Reggio EmiliaDivision of Oncology, Department of Medical and Surgical Sciences for Children and Adults, University-Hospital of Modena and Reggio EmiliaDivision of Oncology, Department of Medical and Surgical Sciences for Children and Adults, University-Hospital of Modena and Reggio EmiliaDivision of Oncology, Department of Medical and Surgical Sciences for Children and Adults, University-Hospital of Modena and Reggio EmiliaDivision of Oncology, Department of Medical and Surgical Sciences for Children and Adults, University-Hospital of Modena and Reggio EmiliaDivision of Plastic Surgery, Department of Medical and Surgical Sciences for Children and Adults, University-Hospital of Modena and Reggio EmiliaDivision of Plastic Surgery, Department of Medical and Surgical Sciences for Children and Adults, University-Hospital of Modena and Reggio EmiliaDivision of Plastic Surgery, Department of Medical and Surgical Sciences for Children and Adults, University-Hospital of Modena and Reggio EmiliaDivision of Plastic Surgery, Department of Medical and Surgical Sciences for Children and Adults, University-Hospital of Modena and Reggio EmiliaAflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta and Emory University Department of PediatricsTechnopole of Mirandola TPMDivision of Oncology, Department of Medical and Surgical Sciences for Children and Adults, University-Hospital of Modena and Reggio EmiliaAbstract Background The ex vivo expansion potential of mesenchymal stromal/stem cells (MSC) together with their differentiation and secretion properties makes these cells an attractive tool for transplantation and tissue engineering. Although the use of MSC is currently being tested in a growing number of clinical trials, it is still desirable to identify molecular markers that may help improve their performance both in vitro and after transplantation. Methods Recently, HOXB7 was identified as a master player driving the proliferation and differentiation of bone marrow mesenchymal progenitors. In this study, we investigated the effect of HOXB7 overexpression on the ex vivo features of adipose mesenchymal progenitors (AD-MSC). Results HOXB7 increased AD-MSC proliferation potential, reduced senescence, and improved chondrogenesis together with a significant increase of basic fibroblast growth factor (bFGF) secretion. Conclusion While further investigations and in vivo models shall be applied for better understanding, these data suggest that modulation of HOXB7 may be a strategy for innovative tissue regeneration applications.http://link.springer.com/article/10.1186/s13287-019-1200-6MSCHOXB7AgingbFGF |
| spellingShingle | Elisabetta Manuela Foppiani Olivia Candini Ilenia Mastrolia Alba Murgia Giulia Grisendi Anna Valeria Samarelli Giulia Boscaini Lucrezia Pacchioni Massimo Pinelli Giorgio De Santis Edwin M. Horwitz Elena Veronesi Massimo Dominici Impact of HOXB7 overexpression on human adipose-derived mesenchymal progenitors Stem Cell Research & Therapy MSC HOXB7 Aging bFGF |
| title | Impact of HOXB7 overexpression on human adipose-derived mesenchymal progenitors |
| title_full | Impact of HOXB7 overexpression on human adipose-derived mesenchymal progenitors |
| title_fullStr | Impact of HOXB7 overexpression on human adipose-derived mesenchymal progenitors |
| title_full_unstemmed | Impact of HOXB7 overexpression on human adipose-derived mesenchymal progenitors |
| title_short | Impact of HOXB7 overexpression on human adipose-derived mesenchymal progenitors |
| title_sort | impact of hoxb7 overexpression on human adipose derived mesenchymal progenitors |
| topic | MSC HOXB7 Aging bFGF |
| url | http://link.springer.com/article/10.1186/s13287-019-1200-6 |
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