Immunomodulatory Properties of Host Defence Peptides in Skin Wound Healing
Cutaneous wound healing is a vital biological process that aids skin regeneration upon injury. Wound healing failure results from persistent inflammatory conditions observed in diabetes, or autoimmune diseases like psoriasis. Chronic wounds are incurable due to factors like poor oxygenation, aberran...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/7/952 |
| _version_ | 1797528504347131904 |
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| author | Marija Petkovic Michelle Vang Mouritzen Biljana Mojsoska Håvard Jenssen |
| author_facet | Marija Petkovic Michelle Vang Mouritzen Biljana Mojsoska Håvard Jenssen |
| author_sort | Marija Petkovic |
| collection | DOAJ |
| description | Cutaneous wound healing is a vital biological process that aids skin regeneration upon injury. Wound healing failure results from persistent inflammatory conditions observed in diabetes, or autoimmune diseases like psoriasis. Chronic wounds are incurable due to factors like poor oxygenation, aberrant function of peripheral sensory nervature, inadequate nutrients and blood tissue supply. The most significant hallmark of chronic wounds is heavily aberrant immune skin function. The immune response in humans relies on a large network of signalling molecules and their interactions. Research studies have reported on the dual role of host defence peptides (HDPs), which are also often called antimicrobial peptides (AMPs). Their duality reflects their potential for acting as antibacterial peptides, and as immunodulators that assist in modulating several biological signalling pathways related to processes such as wound healing, autoimmune disease, and others. HDPs may differentially control gene regulation and alter the behaviour of epithelial and immune cells, resulting in modulation of immune responses. In this review, we shed light on the understanding and most recent advances related to molecular mechanisms and immune modulatory features of host defence peptides in human skin wound healing. Understanding their functional role in skin immunity may further inspire topical treatments for chronic wounds. |
| first_indexed | 2024-03-10T09:59:18Z |
| format | Article |
| id | doaj.art-0a2971ea334049d1b420b15bb75a3831 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T09:59:18Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-0a2971ea334049d1b420b15bb75a38312023-11-22T02:02:42ZengMDPI AGBiomolecules2218-273X2021-06-0111795210.3390/biom11070952Immunomodulatory Properties of Host Defence Peptides in Skin Wound HealingMarija Petkovic0Michelle Vang Mouritzen1Biljana Mojsoska2Håvard Jenssen3Department of Science and Environment, Roskilde University, 4000 Roskilde, DenmarkDepartment of Science and Environment, Roskilde University, 4000 Roskilde, DenmarkDepartment of Science and Environment, Roskilde University, 4000 Roskilde, DenmarkDepartment of Science and Environment, Roskilde University, 4000 Roskilde, DenmarkCutaneous wound healing is a vital biological process that aids skin regeneration upon injury. Wound healing failure results from persistent inflammatory conditions observed in diabetes, or autoimmune diseases like psoriasis. Chronic wounds are incurable due to factors like poor oxygenation, aberrant function of peripheral sensory nervature, inadequate nutrients and blood tissue supply. The most significant hallmark of chronic wounds is heavily aberrant immune skin function. The immune response in humans relies on a large network of signalling molecules and their interactions. Research studies have reported on the dual role of host defence peptides (HDPs), which are also often called antimicrobial peptides (AMPs). Their duality reflects their potential for acting as antibacterial peptides, and as immunodulators that assist in modulating several biological signalling pathways related to processes such as wound healing, autoimmune disease, and others. HDPs may differentially control gene regulation and alter the behaviour of epithelial and immune cells, resulting in modulation of immune responses. In this review, we shed light on the understanding and most recent advances related to molecular mechanisms and immune modulatory features of host defence peptides in human skin wound healing. Understanding their functional role in skin immunity may further inspire topical treatments for chronic wounds.https://www.mdpi.com/2218-273X/11/7/952antimicrobial peptideshost defence peptideschronic woundsskin wound healinginflammationskin immune response |
| spellingShingle | Marija Petkovic Michelle Vang Mouritzen Biljana Mojsoska Håvard Jenssen Immunomodulatory Properties of Host Defence Peptides in Skin Wound Healing Biomolecules antimicrobial peptides host defence peptides chronic wounds skin wound healing inflammation skin immune response |
| title | Immunomodulatory Properties of Host Defence Peptides in Skin Wound Healing |
| title_full | Immunomodulatory Properties of Host Defence Peptides in Skin Wound Healing |
| title_fullStr | Immunomodulatory Properties of Host Defence Peptides in Skin Wound Healing |
| title_full_unstemmed | Immunomodulatory Properties of Host Defence Peptides in Skin Wound Healing |
| title_short | Immunomodulatory Properties of Host Defence Peptides in Skin Wound Healing |
| title_sort | immunomodulatory properties of host defence peptides in skin wound healing |
| topic | antimicrobial peptides host defence peptides chronic wounds skin wound healing inflammation skin immune response |
| url | https://www.mdpi.com/2218-273X/11/7/952 |
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