Reticulocytosis in screen-printing workers exposed to 2-butoxyethanol and 2-ethoxyethanol
Abstract Background Studies on the hematologic toxicity of ethylene glycol ethers in humans are limited. Therefore, the aim of this study was to examine the association between exposure to solvents (containing 2-butoxyethanol and 2-ethoxyethanol) and hematological effects. Methods Thirty-four screen...
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| Format: | Article |
| Language: | English |
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Korean Society of Occupational & Environmental Medicine
2017-11-01
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| Series: | Annals of Occupational and Environmental Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40557-017-0210-z |
| _version_ | 1828374673605263360 |
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| author | Seng-Ho Song Seong-Kyu Kang Won-Jun Choi Kyeong Min Kwak Dong-Hoon Lee Dyuk-Yoon Kang Sang-Ha Lee |
| author_facet | Seng-Ho Song Seong-Kyu Kang Won-Jun Choi Kyeong Min Kwak Dong-Hoon Lee Dyuk-Yoon Kang Sang-Ha Lee |
| author_sort | Seng-Ho Song |
| collection | DOAJ |
| description | Abstract Background Studies on the hematologic toxicity of ethylene glycol ethers in humans are limited. Therefore, the aim of this study was to examine the association between exposure to solvents (containing 2-butoxyethanol and 2-ethoxyethanol) and hematological effects. Methods Thirty-four screen-printing workers who were exposed to 2-butoxyethanol and 2-ethoxyethanol and 37 non-exposed clerical workers were selected using data from the health care facilities that provided regular health screening services. Student’s t-tests and Pearson’s chi-square tests were used to compare differences in hematological parameters between the exposed and the control groups. A multivariate analysis was performed using the multiple logistic regression models to adjust for other variables. Results The chi-square test showed the reticulocyte percentages and corrected reticulocyte counts to be significantly higher in the exposed group. The t-tests showed a significant increase in white blood cell counts, reticulocyte percentages, and corrected reticulocyte count (i.e., reticulocyte index) in the exposed group, with p-values of 0.002, 0.004, and 0.002, respectively. Multivariate analysis showed the odds ratio for the corrected reticulocyte counts to be 16.30 for the exposed group, when compared with that of the control group. Conclusions Exposure to 2-butoxyethanol and 2-ethoxyethanol was significantly associated with reticulocytosis, necessitating the implementation of preventive measures for workers prone to occupational exposure to ethylene glycol ethers. |
| first_indexed | 2024-04-14T07:36:23Z |
| format | Article |
| id | doaj.art-0a2c026902a349aaaaf002209c0ab489 |
| institution | Directory Open Access Journal |
| issn | 2052-4374 |
| language | English |
| last_indexed | 2024-04-14T07:36:23Z |
| publishDate | 2017-11-01 |
| publisher | Korean Society of Occupational & Environmental Medicine |
| record_format | Article |
| series | Annals of Occupational and Environmental Medicine |
| spelling | doaj.art-0a2c026902a349aaaaf002209c0ab4892022-12-22T02:05:40ZengKorean Society of Occupational & Environmental MedicineAnnals of Occupational and Environmental Medicine2052-43742017-11-012911810.1186/s40557-017-0210-zReticulocytosis in screen-printing workers exposed to 2-butoxyethanol and 2-ethoxyethanolSeng-Ho Song0Seong-Kyu Kang1Won-Jun Choi2Kyeong Min Kwak3Dong-Hoon Lee4Dyuk-Yoon Kang5Sang-Ha Lee6Department of Occupational and Environmental Medicine, Gachon University Gil Medical CenterDepartment of Occupational and Environmental Medicine, Gachon University Gil Medical CenterDepartment of Occupational and Environmental Medicine, Gachon University Gil Medical CenterDepartment of Occupational and Environmental Medicine, Gachon University Gil Medical CenterDepartment of Occupational and Environmental Medicine, Gachon University Gil Medical CenterDepartment of Occupational and Environmental Medicine, Gachon University Gil Medical CenterDepartment of Occupational and Environmental Medicine, Gachon University Gil Medical CenterAbstract Background Studies on the hematologic toxicity of ethylene glycol ethers in humans are limited. Therefore, the aim of this study was to examine the association between exposure to solvents (containing 2-butoxyethanol and 2-ethoxyethanol) and hematological effects. Methods Thirty-four screen-printing workers who were exposed to 2-butoxyethanol and 2-ethoxyethanol and 37 non-exposed clerical workers were selected using data from the health care facilities that provided regular health screening services. Student’s t-tests and Pearson’s chi-square tests were used to compare differences in hematological parameters between the exposed and the control groups. A multivariate analysis was performed using the multiple logistic regression models to adjust for other variables. Results The chi-square test showed the reticulocyte percentages and corrected reticulocyte counts to be significantly higher in the exposed group. The t-tests showed a significant increase in white blood cell counts, reticulocyte percentages, and corrected reticulocyte count (i.e., reticulocyte index) in the exposed group, with p-values of 0.002, 0.004, and 0.002, respectively. Multivariate analysis showed the odds ratio for the corrected reticulocyte counts to be 16.30 for the exposed group, when compared with that of the control group. Conclusions Exposure to 2-butoxyethanol and 2-ethoxyethanol was significantly associated with reticulocytosis, necessitating the implementation of preventive measures for workers prone to occupational exposure to ethylene glycol ethers.http://link.springer.com/article/10.1186/s40557-017-0210-z2-Butoxyethanol2-EthoxyethanolEthylene glycol ethersReticulocytosis |
| spellingShingle | Seng-Ho Song Seong-Kyu Kang Won-Jun Choi Kyeong Min Kwak Dong-Hoon Lee Dyuk-Yoon Kang Sang-Ha Lee Reticulocytosis in screen-printing workers exposed to 2-butoxyethanol and 2-ethoxyethanol Annals of Occupational and Environmental Medicine 2-Butoxyethanol 2-Ethoxyethanol Ethylene glycol ethers Reticulocytosis |
| title | Reticulocytosis in screen-printing workers exposed to 2-butoxyethanol and 2-ethoxyethanol |
| title_full | Reticulocytosis in screen-printing workers exposed to 2-butoxyethanol and 2-ethoxyethanol |
| title_fullStr | Reticulocytosis in screen-printing workers exposed to 2-butoxyethanol and 2-ethoxyethanol |
| title_full_unstemmed | Reticulocytosis in screen-printing workers exposed to 2-butoxyethanol and 2-ethoxyethanol |
| title_short | Reticulocytosis in screen-printing workers exposed to 2-butoxyethanol and 2-ethoxyethanol |
| title_sort | reticulocytosis in screen printing workers exposed to 2 butoxyethanol and 2 ethoxyethanol |
| topic | 2-Butoxyethanol 2-Ethoxyethanol Ethylene glycol ethers Reticulocytosis |
| url | http://link.springer.com/article/10.1186/s40557-017-0210-z |
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