Brain metastases from Truncal and extremity bone and soft tissue sarcoma: Single institution study of oncologic outcomes
Brain metastases are a rare occurrence in patients with sarcoma. The prognosis for patients is poor, and treatment can contribute to considerable morbidity. We sought to examine the experience of our institution in managing these patients over a period of 17 years. We performed a retrospective cohor...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-09-01
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| Series: | Rare Tumors |
| Online Access: | https://doi.org/10.1177/2036361320960060 |
| _version_ | 1818485677522681856 |
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| author | Chung Ming Chan Adam D Lindsay Andre RV Spiguel Mark T Scarborough C Parker Gibbs |
| author_facet | Chung Ming Chan Adam D Lindsay Andre RV Spiguel Mark T Scarborough C Parker Gibbs |
| author_sort | Chung Ming Chan |
| collection | DOAJ |
| description | Brain metastases are a rare occurrence in patients with sarcoma. The prognosis for patients is poor, and treatment can contribute to considerable morbidity. We sought to examine the experience of our institution in managing these patients over a period of 17 years. We performed a retrospective cohort study of patients managed for sarcoma of the extremity or trunk who developed brain metastases from 2000 to 2017. Clinical data were analyzed and we assessed survival outcomes. 14 patients presenting at a mean age of 46.7 years were included. All patients were treated with radiotherapy for their brain metastases. 3 patients underwent surgical excision of their intracranial metastases. Two patients were treated with radium-223 dichloride. Kaplan–Meier survival analysis and the log rank test were used to calculate the survival probability, and to compare patient subgroups. All patients in this study developed lung or bone metastases at a mean interval of 13.3 months prior to the development of brain metastasis. The median interval from diagnosis of a brain metastasis to death was 3.6 months. The Kaplan–Meier survival probability at 6 months was 28.6%, and 14.3% at 1 year. Surgery was not found to be associated with increased survival. Patients with cerebellar metastasis had increased survival probability as compared to those with cerebral metastasis. Patients with extremity or trunk sarcoma who develop brain metastases frequently develop lung or bone metastases in the year preceding their diagnosis of brain metastasis. Patients with cerebellar metastasis may have better survival than those with cerebral metastasis, and an aggressive treatment approach should be considered. Despite aggressive treatment, the prognosis is grim. |
| first_indexed | 2024-12-10T16:12:09Z |
| format | Article |
| id | doaj.art-0a2ebf863558466e9f8d1b555b0f0e9a |
| institution | Directory Open Access Journal |
| issn | 2036-3613 |
| language | English |
| last_indexed | 2024-12-10T16:12:09Z |
| publishDate | 2020-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Rare Tumors |
| spelling | doaj.art-0a2ebf863558466e9f8d1b555b0f0e9a2022-12-22T01:42:04ZengSAGE PublishingRare Tumors2036-36132020-09-011210.1177/2036361320960060Brain metastases from Truncal and extremity bone and soft tissue sarcoma: Single institution study of oncologic outcomesChung Ming Chan0Adam D Lindsay1Andre RV Spiguel2Mark T Scarborough3C Parker Gibbs4Division of Orthopaedic Oncology, Department of Orthopaedics and Rehabilitation, University of Florida, Gainesville, FL, USADepartment of Orthopaedic Surgery, University of Connecticut, Farmington, CT, USADivision of Orthopaedic Oncology, Department of Orthopaedics and Rehabilitation, University of Florida, Gainesville, FL, USADivision of Orthopaedic Oncology, Department of Orthopaedics and Rehabilitation, University of Florida, Gainesville, FL, USADivision of Orthopaedic Oncology, Department of Orthopaedics and Rehabilitation, University of Florida, Gainesville, FL, USABrain metastases are a rare occurrence in patients with sarcoma. The prognosis for patients is poor, and treatment can contribute to considerable morbidity. We sought to examine the experience of our institution in managing these patients over a period of 17 years. We performed a retrospective cohort study of patients managed for sarcoma of the extremity or trunk who developed brain metastases from 2000 to 2017. Clinical data were analyzed and we assessed survival outcomes. 14 patients presenting at a mean age of 46.7 years were included. All patients were treated with radiotherapy for their brain metastases. 3 patients underwent surgical excision of their intracranial metastases. Two patients were treated with radium-223 dichloride. Kaplan–Meier survival analysis and the log rank test were used to calculate the survival probability, and to compare patient subgroups. All patients in this study developed lung or bone metastases at a mean interval of 13.3 months prior to the development of brain metastasis. The median interval from diagnosis of a brain metastasis to death was 3.6 months. The Kaplan–Meier survival probability at 6 months was 28.6%, and 14.3% at 1 year. Surgery was not found to be associated with increased survival. Patients with cerebellar metastasis had increased survival probability as compared to those with cerebral metastasis. Patients with extremity or trunk sarcoma who develop brain metastases frequently develop lung or bone metastases in the year preceding their diagnosis of brain metastasis. Patients with cerebellar metastasis may have better survival than those with cerebral metastasis, and an aggressive treatment approach should be considered. Despite aggressive treatment, the prognosis is grim.https://doi.org/10.1177/2036361320960060 |
| spellingShingle | Chung Ming Chan Adam D Lindsay Andre RV Spiguel Mark T Scarborough C Parker Gibbs Brain metastases from Truncal and extremity bone and soft tissue sarcoma: Single institution study of oncologic outcomes Rare Tumors |
| title | Brain metastases from Truncal and extremity bone and soft tissue sarcoma: Single institution study of oncologic outcomes |
| title_full | Brain metastases from Truncal and extremity bone and soft tissue sarcoma: Single institution study of oncologic outcomes |
| title_fullStr | Brain metastases from Truncal and extremity bone and soft tissue sarcoma: Single institution study of oncologic outcomes |
| title_full_unstemmed | Brain metastases from Truncal and extremity bone and soft tissue sarcoma: Single institution study of oncologic outcomes |
| title_short | Brain metastases from Truncal and extremity bone and soft tissue sarcoma: Single institution study of oncologic outcomes |
| title_sort | brain metastases from truncal and extremity bone and soft tissue sarcoma single institution study of oncologic outcomes |
| url | https://doi.org/10.1177/2036361320960060 |
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