Antithrombin III Protects Against Contrast-Induced Nephropathy
We previously reported that insufficiency of antithrombin III (ATIII), the major anti-coagulation molecule in vivo, exacerbated renal ischemia-reperfusion injury in animal models and possibly humans. In the present study, we investigated the relationship between ATIII level and contrast induced neph...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-03-01
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| Series: | EBioMedicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396417300683 |
| _version_ | 1818538032634003456 |
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| author | Zeyuan Lu Dongsheng Cheng Jianyong Yin Rui Wu Guangyuan Zhang Qing Zhao Niansong Wang Feng Wang Mingyu Liang |
| author_facet | Zeyuan Lu Dongsheng Cheng Jianyong Yin Rui Wu Guangyuan Zhang Qing Zhao Niansong Wang Feng Wang Mingyu Liang |
| author_sort | Zeyuan Lu |
| collection | DOAJ |
| description | We previously reported that insufficiency of antithrombin III (ATIII), the major anti-coagulation molecule in vivo, exacerbated renal ischemia-reperfusion injury in animal models and possibly humans. In the present study, we investigated the relationship between ATIII level and contrast induced nephropathy (CIN) in patients and examined therapeutic effect of ATIII on CIN in Sprague-Dawley rats. Patients with low ATIII activity presented a higher incidence of acute kidney injury (AKI) following coronary angiography. ATIII (500 μg/kg) was intravenously injected before or after the induction of AKI in rats. Our data demonstrated ATIII significantly attenuated the elevation of serum creatinine, blood urea nitrogen, and renal histological injury. The beneficial effects of ATIII were accompanied by diminished renal inflammatory response, oxidative stress, cell apoptosis and improved renal blood flow in rats. In conclusion, ATIII appears to attenuate CIN through inhibiting inflammation, oxidative stress, apoptosis and improving renal blood flow. ATIII administration may represent a promising strategy for the prevention and treatment of contrast-induced AKI. |
| first_indexed | 2024-12-11T18:58:22Z |
| format | Article |
| id | doaj.art-0a319878d9ec4eb59c283dee0f1fdf50 |
| institution | Directory Open Access Journal |
| issn | 2352-3964 |
| language | English |
| last_indexed | 2024-12-11T18:58:22Z |
| publishDate | 2017-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EBioMedicine |
| spelling | doaj.art-0a319878d9ec4eb59c283dee0f1fdf502022-12-22T00:54:04ZengElsevierEBioMedicine2352-39642017-03-0117C10110710.1016/j.ebiom.2017.02.009Antithrombin III Protects Against Contrast-Induced NephropathyZeyuan Lu0Dongsheng Cheng1Jianyong Yin2Rui Wu3Guangyuan Zhang4Qing Zhao5Niansong Wang6Feng Wang7Mingyu Liang8Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaDepartment of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaDepartment of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaDepartment of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaDepartment of Urology, Zhongda Hospital, Southeast University, Nanjing, ChinaDepartment of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaDepartment of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaDepartment of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, USAWe previously reported that insufficiency of antithrombin III (ATIII), the major anti-coagulation molecule in vivo, exacerbated renal ischemia-reperfusion injury in animal models and possibly humans. In the present study, we investigated the relationship between ATIII level and contrast induced nephropathy (CIN) in patients and examined therapeutic effect of ATIII on CIN in Sprague-Dawley rats. Patients with low ATIII activity presented a higher incidence of acute kidney injury (AKI) following coronary angiography. ATIII (500 μg/kg) was intravenously injected before or after the induction of AKI in rats. Our data demonstrated ATIII significantly attenuated the elevation of serum creatinine, blood urea nitrogen, and renal histological injury. The beneficial effects of ATIII were accompanied by diminished renal inflammatory response, oxidative stress, cell apoptosis and improved renal blood flow in rats. In conclusion, ATIII appears to attenuate CIN through inhibiting inflammation, oxidative stress, apoptosis and improving renal blood flow. ATIII administration may represent a promising strategy for the prevention and treatment of contrast-induced AKI.http://www.sciencedirect.com/science/article/pii/S2352396417300683Antithrombin IIIAcute kidney injuryContrast induced nephropathyInflammation |
| spellingShingle | Zeyuan Lu Dongsheng Cheng Jianyong Yin Rui Wu Guangyuan Zhang Qing Zhao Niansong Wang Feng Wang Mingyu Liang Antithrombin III Protects Against Contrast-Induced Nephropathy EBioMedicine Antithrombin III Acute kidney injury Contrast induced nephropathy Inflammation |
| title | Antithrombin III Protects Against Contrast-Induced Nephropathy |
| title_full | Antithrombin III Protects Against Contrast-Induced Nephropathy |
| title_fullStr | Antithrombin III Protects Against Contrast-Induced Nephropathy |
| title_full_unstemmed | Antithrombin III Protects Against Contrast-Induced Nephropathy |
| title_short | Antithrombin III Protects Against Contrast-Induced Nephropathy |
| title_sort | antithrombin iii protects against contrast induced nephropathy |
| topic | Antithrombin III Acute kidney injury Contrast induced nephropathy Inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S2352396417300683 |
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